Results 211 to 220 of about 2,679,159 (249)
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The (Pro)Renin Receptor and the Kidney
Seminars in Nephrology, 2007Prorenin binding to the (pro)renin receptor not only causes a nonproteolytic activation of prorenin leading to the activation of the renin-angiotensin system (RAS), but also stimulates the receptor's own intracellular signaling pathways independent of the RAS.
Atsuhiro, Ichihara +4 more
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Renin, Prorenin, and the (Pro)Renin Receptor
2009The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin angiotensin system (RAS) and has brought prorenin back in the spotlight.
Genevieve Nguyen, Aurelie Contrepas
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Soluble (Pro)Renin Receptor in Hypertension
Nephron, 2022The (pro)renin receptor (PRR) was originally cloned as a specific single-transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physiopathological processes.
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The (pro)renin receptor in health and disease
Nature Reviews Nephrology, 2019The (pro)renin receptor ((P)RR) was first identified as a single-transmembrane receptor in human kidneys and initially attracted attention owing to its potential role as a regulator of the tissue renin-angiotensin system (RAS). Subsequent studies found that the (P)RR is widely distributed in organs throughout the body, including the kidneys, heart ...
Atsuhiro Ichihara, Midori Sasaki Yatabe
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The (pro)renin receptor: therapeutic consequences
Expert Opinion on Investigational Drugs, 2006It is generally assumed that the beneficial effects of renin-angiotensin system blockers in cardiovascular disease are due to blockade of the generation or action of angiotensin at tissue sites. Such generation depends on the uptake of renin and/or its inactive precursor prorenin from the circulation.
Nguyen, G, Danser, Jan
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Physiology and pharmacology of the (pro)renin receptor
Current Opinion in Pharmacology, 2008The (pro)renin receptor [(P)RR] is a single trans-membrane domain receptor that mediates renin and prorenin specific effects. The receptor acts as co-factor for renin and prorenin by increasing their enzymatic activity on the cell-surface and it activates the mitogen activated protein kinases ERK1/2 cascade leading to cell proliferation and to up ...
Geneviève, Nguyen, Aurélie, Contrepas
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The (pro)renin receptor ((P)RR) and soluble (pro)renin receptor (s(P)RR) in pregnancy
Placenta, 2021The (pro)renin receptor ((P)RR) is a multi-functional protein that can be proteolytically cleaved and released in a soluble form (s(P)RR). Recently, the (P)RR and s(P)RR have become of interest in pregnancy and its associated pathologies. This is because the (P)RR not only activates tissue renin angiotensin systems, but it is also an integral component
Saije K. Morosin +4 more
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Placenta, 2016
The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Tatsuya Nartita +7 more
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The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Tatsuya Nartita +7 more
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(Pro)renin receptor in the kidney: function and significance
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2021(Pro)renin receptor (PRR), a 350-amino acid receptor initially thought of as a receptor for the binding of renin and prorenin, is multifunctional. In addition to its role in the renin-angiotensin system (RAS), PRR transduces several intracellular signaling molecules and is a component of the vacuolar H+-ATPase that participates in autophagy.
Gertrude, Arthur +2 more
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Nihon rinsho. Japanese journal of clinical medicine, 2009
Discovery of (pro)renin receptor elucidated that prorenin is not only an inactive precursor of renin but also an endocrine hormone. The binding of prorenin to the (pro) renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of nonproteolytic activation of prorenin, and the angiotensin II-independent, (pro)renin ...
Atsuhiro, Ichihara, Hiroshi, Ito
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Discovery of (pro)renin receptor elucidated that prorenin is not only an inactive precursor of renin but also an endocrine hormone. The binding of prorenin to the (pro) renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of nonproteolytic activation of prorenin, and the angiotensin II-independent, (pro)renin ...
Atsuhiro, Ichihara, Hiroshi, Ito
openaire +1 more source