Results 211 to 220 of about 32,074 (246)
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The (pro)renin receptor in health and disease
Nature Reviews Nephrology, 2019The (pro)renin receptor ((P)RR) was first identified as a single-transmembrane receptor in human kidneys and initially attracted attention owing to its potential role as a regulator of the tissue renin-angiotensin system (RAS). Subsequent studies found that the (P)RR is widely distributed in organs throughout the body, including the kidneys, heart ...
Atsuhiro Ichihara, Midori Sasaki Yatabe
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The (pro)renin receptor ((P)RR) and soluble (pro)renin receptor (s(P)RR) in pregnancy
Placenta, 2021The (pro)renin receptor ((P)RR) is a multi-functional protein that can be proteolytically cleaved and released in a soluble form (s(P)RR). Recently, the (P)RR and s(P)RR have become of interest in pregnancy and its associated pathologies. This is because the (P)RR not only activates tissue renin angiotensin systems, but it is also an integral component
Saije Endacott +2 more
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Renin, (pro)renin and receptor: an update
Clinical Science, 2010PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/2. However the gene encoding for PRR is named ATP6ap2 (ATPase 6 accessory protein 2) because PRR was initially found ...
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The (pro)renin receptor: therapeutic consequences
Expert Opinion on Investigational Drugs, 2006It is generally assumed that the beneficial effects of renin-angiotensin system blockers in cardiovascular disease are due to blockade of the generation or action of angiotensin at tissue sites. Such generation depends on the uptake of renin and/or its inactive precursor prorenin from the circulation.
Nguyen, G, Danser, Jan
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Placenta, 2016
The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Hiroyuki Seki +2 more
exaly +3 more sources
The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Hiroyuki Seki +2 more
exaly +3 more sources
Physiology and pharmacology of the (pro)renin receptor
Current Opinion in Pharmacology, 2008The (pro)renin receptor [(P)RR] is a single trans-membrane domain receptor that mediates renin and prorenin specific effects. The receptor acts as co-factor for renin and prorenin by increasing their enzymatic activity on the cell-surface and it activates the mitogen activated protein kinases ERK1/2 cascade leading to cell proliferation and to up ...
Geneviève, Nguyen, Aurélie, Contrepas
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The (pro)renin receptor: A new addition to the renin–angiotensin system?
European Journal of Pharmacology, 2008The renin-angiotensin system is still incompletely understood. In particular, the function of prorenin, the inactive precursor of renin, is unknown. Yet, prorenin levels are >10-fold higher than renin levels, and prorenin increases even further in subjects with diabetes mellitus displaying microvascular complications.
Batenburg, Wendy, Danser, Jan
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(Pro)renin and (pro)renin receptor expression during kidney development in neonates
European Journal of Pediatrics, 2016Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and
Tomomasa Terada +4 more
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Nihon rinsho. Japanese journal of clinical medicine, 2009
Discovery of (pro)renin receptor elucidated that prorenin is not only an inactive precursor of renin but also an endocrine hormone. The binding of prorenin to the (pro) renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of nonproteolytic activation of prorenin, and the angiotensin II-independent, (pro)renin ...
Atsuhiro, Ichihara, Hiroshi, Ito
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Discovery of (pro)renin receptor elucidated that prorenin is not only an inactive precursor of renin but also an endocrine hormone. The binding of prorenin to the (pro) renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of nonproteolytic activation of prorenin, and the angiotensin II-independent, (pro)renin ...
Atsuhiro, Ichihara, Hiroshi, Ito
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Twenty years of the (pro)renin receptor
Journal of the American Society of Hypertension, 2008The (pro)renin receptor [(P)RR] specifically binds renin and prorenin and mediates their intracellular effects. It acts as co-factor for renin and prorenin by increasing their enzymatic activity on the cell-surface and it activates the mitogen activated protein kinases ERK1/2 (extracellular signal regulated kinase) cascade leading to cell proliferation
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