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Twenty years of the (pro)renin receptor
Journal of the American Society of Hypertension, 2008The (pro)renin receptor [(P)RR] specifically binds renin and prorenin and mediates their intracellular effects. It acts as co-factor for renin and prorenin by increasing their enzymatic activity on the cell-surface and it activates the mitogen activated protein kinases ERK1/2 (extracellular signal regulated kinase) cascade leading to cell proliferation
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(Pro)renin Receptor as a New Drug Target
Current Pharmaceutical Design, 2011Over the last few years, the implication of the (pro)renin receptor [(P)RR] in the pathogenesis of end-organ damage has been shown through many different studies. The (P)RR plays a dual role when stimulated by renin or prorenin as it enhances both cell surface production of angiotensin and stimulates angiotensin-independent intracellular signaling ...
Basma A M, Ahmed +2 more
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Role of (pro)renin receptor in cyclosporin A-induced nephropathy
American Journal of Physiology - Renal Physiology, 2022J David Symons, Tianxin Yang, Aihua Lu
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Brain-Targeted (Pro)renin Receptor Knockdown Attenuates Angiotensin II–Dependent Hypertension
Hypertension, 2012Yumei Feng, Wencheng Li
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Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension
Hypertension, 2014Scott Earley +2 more
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