Results 31 to 40 of about 16,494 (203)
Viruses, 2022 Viral replication and transmissibility are the principal causes of endemic and pandemic disease threats. There remains a need for broad-spectrum antiviral agents.
R. Tripp, David E Martin
semanticscholar +1 more source
Drug repurposing for cardiovascular diseases: New targets and indications for probenecid
British Journal of Pharmacology, 2022 The available pharmacological options in the management of cardiovascular diseases such as ischaemic heart disease and subsequent heart failure are effective in slowing the progression of this condition.
Zsófia Onódi +4 more
semanticscholar +1 more source
Addition of probenecid to oral β-lactam antibiotics: a systematic review and meta-analysis
Journal of Antimicrobial Chemotherapy, 2022 Objectives To explore the literature comparing the pharmacokinetic and clinical outcomes from adding probenecid to oral β-lactams. Methods Medline and EMBASE were searched from inception to December 2021 for all English language studies comparing the ...
Richard C. Wilson +7 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Objectives: Probenecid is an anion transport inhibitor, which, according to the connectivity map (CMap; a biological application database), interferes with hypoxia-induced gene expression changes in retinal vascular endothelial cells (ECs).
Jingbo Jiang +10 more
doaj +1 more source
Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro
Scientific Reports, 2021 Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19.
J. Murray +8 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2022 Proinflammatory immune cell subsets constitute the majority in the local microenvironment after spinal cord injury (SCI), leading to secondary pathological injury.
Qi Qi +14 more
doaj +1 more source
Therapeutic Advances in Medical Oncology, 2022 Introduction: In breast cancer patients treated with the anti-estrogen tamoxifen, low concentrations of the active metabolite endoxifen are associated with more disease recurrence.
Stefan A. J. Buck +12 more
doaj +1 more source
Pharmaceutical Research, 2020 To provide whole-body physiologically based pharmacokinetic (PBPK) models of the potent clinical organic anion transporter (OAT) inhibitor probenecid and the clinical OAT victim drug furosemide for their application in transporter-based drug-drug ...
Hannah Britz +8 more
semanticscholar +1 more source
Current Therapeutic Research, 2014 Background: Olmesartan is an angiotensin II receptor antagonist and is effective and well tolerated in the treatment of arterial hypertension. Probenecid is a well-established hypouricemic agent for the treatment of hyperuricemia and gout. Objective: The
Kun-Yan Li, PhD +6 more
doaj +1 more source
Physiological Reports, 2023 Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov +5 more
doaj +1 more source