Results 41 to 50 of about 16,494 (203)
Assessing a potential role of host Pannexin 1 during Chlamydia trachomatis infection. [PDF]
PLoS ONE, 2013 Pannexin 1 (Panx1) is a plasma membrane channel glycoprotein that plays a role in innate immune response through association with the inflammasome complex.
Mary J McKuen +2 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Sulphonamide and 1,3,4-oxadiazole moieties are present as integral structural parts of many drugs and pharmaceuticals. Taking into account the significance of these moieties, we herein present the synthesis, single-crystal X-ray analysis, DFT studies ...
Bilal Ahmad Khan +7 more
doaj +1 more source
Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways
Angewandte Chemie, EarlyView.A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim +3 more
wiley +2 more sources
Viruses, 2023 In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements.
Ralph A. Tripp, David E. Martin
doaj +1 more source
Journal of Chemical and Engineering Data, 2019 The solubility data of probenecid in 12 different organic solvents including methanol, methyl acetate, ethanol, ethyl acetate, n-propanol, n-butanol, butyl acetate, n-pentanol, isopropanol, isobutanol, acetone, and methyl tert-butyl ether was measured ...
Jiakang Shi +4 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández +7 more
wiley +1 more source
Biomolecules, 2020 The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes
Camilo P. Martínez-Reyes +8 more
doaj +1 more source
Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family
European Thyroid Journal, 2023 Objective: Thyroid hormone (TH) transport represents a critical first step in governing intracellular TH regulation. It is still unknown whether the full repertoire of TH transporters has been identified.
Zhongli Chen +11 more
doaj +1 more source
Inhibitory Effect of Probenecid on Osteoclast Formation via JNK, ROS and COX-2
Biomolecules & Therapeutics, 2019 Probenecid is a representative drug used in the treatment of gout. A recent study showed that probenecid effectively inhibits oxidative stress in neural cells.
Mingshan Cheng, Sung-jin Kim
semanticscholar +1 more source