Results 71 to 80 of about 16,494 (203)
Baicalin and probenecid protect against Glaesserella parasuis challenge in a piglet model
Veterinary ResearchGlaesserella parasuis (G. parasuis) induces vascular damage and systemic inflammation. However, the mechanism by which it causes vascular damage is currently unclear. Baicalin has important anti-inflammatory, antibacterial and immunomodulatory functions.
Shulin Fu +13 more
doaj +1 more source
The Probenecid-Story - a Success in the Fight against Doping through Out-of-Competition Testing.
Drug Testing and Analysis, 2019 The effectiveness of doping control in sport has been continuously improved during the past 50 years. One of the major steps forward was the introduction of unannounced and targeted out-of-competition testing in order to control the misuse of anabolic ...
P. Hemmersbach
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov +8 more
wiley +1 more source
Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient
The Journal of Physiology, EarlyView.Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, 2018 The primary aim of this study was to assess the individual effects of probenecid and cimetidine on mirogabalin exposure.
Masaya Tachibana +7 more
semanticscholar +1 more source
Long‐Term Opioids in Gout: A Matched Cohort Study From the Veterans Health Administration
Arthritis Care &Research, Volume 78, Issue 3, Page 344-351, March 2026.Objective Though used frequently to treat flare, risk of long‐term opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed long‐term opioids over time.
Lindsay N. Helget +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 13, 3 March 2026.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury
Neurotherapeutics, 2023 R. Clark +3 more
semanticscholar +1 more source
Oral probenecid improves sperm motility in men with spinal cord injury
Journal of Spinal Cord Medicine (JSCM), 2017 Study Design: Prospective cohort study (twenty men with spinal cord injury [SCI]). Objective: Determine if administration of oral probenecid results in improved sperm motility in men with SCI. Setting: Major university medical center. Methods: Twenty men
E. Ibrahim +3 more
semanticscholar +1 more source
Heart Failure: Epidemiology, Pathophysiology, and Management
MedComm, Volume 7, Issue 3, March 2026.This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan +9 more
wiley +1 more source