Results 141 to 150 of about 2,435,950 (372)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Metode Markov Chain Untuk Prediksi Probing Terhadap Kinerja Promotor Pada Penjualan Oppo

open access: yesInfotekmesin: Media Komunikasi Ilmiah Politeknik Cilacap, 2020
Jani Kusanti, Tri Irianto Tjendrowasono
doaj   +1 more source

Probing the pre-BBN universe with gravitational waves from cosmic strings [PDF]

open access: diamond, 2019
Yanou Cui   +3 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Periodontal probes and probing.

open access: yesInternational dental journal, 1995
Probing of the sensitive, soft periodontal tissues differs markedly from probing of the dental hard tissues and caries. Periodontal probing requires special skills as well as an understanding of the tissues being examined, the probing procedure and the use of an appropriately designed instrument.
openaire   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

The Effects of Quantity and Quality of Teachers’ Probing and Guiding Questions on Student Performance

open access: yesSakarya University Journal of Education, 2015
This study investigated the types, quantity, and quality of teacher questions and their impact on student understanding. In contrast to previous studies, in order to obtain optimum effects of question types, quantity, and quality, this study controlled ...
Alpaslan Sahin
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Congenital nasolacrimal duct obstruction: caesarean section vs. vaginal delivery [PDF]

open access: yesMedicinski Glasnik, 2018
Aim To investigate the association between the incidence of congenital nasolacrimal duct obstruction (CNDO) and delivery by caesarean section or spontaneous vaginal labour.
Aydın Yildiz
doaj  

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