Results 141 to 150 of about 387,004 (310)
Periodontal probes and probing.
International dental journal, 1995 Probing of the sensitive, soft periodontal tissues differs markedly from probing of the dental hard tissues and caries. Periodontal probing requires special skills as well as an understanding of the tissues being examined, the probing procedure and the use of an appropriately designed instrument.
openaire +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Atomic force microscopy probing in the measurement of cell mechanics
, 2010 Dimitrios Kirmizis, Stergios LogothetidisDepartment of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology, Aristotle University, Thessaloniki, GreeceAbstract: Atomic force microscope (AFM) has been used incrementally over the last decade in
Stergios Logothetidis +1 more
core
Optimization of Probing Needle Design for Wafer-level Probing Test
The probing test is a typical quality control method for individual chips on a wafer. With a proper design, the service life of probing needles in the probe card can be sufficiently elongated and hence reduces the testing cost.
Yi-Shao Lai, Meng-Kai Shih
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Research on cyberspace surveying and mapping technology
网络与信息安全学报, 2016 Cyberspace surveying and mapping technology is a network common foundation and application technology.The research progress of cyberspace surveying and mapping technology was reviewed and discussed.Firstly,the con-notation and principle framework of ...
Fan ZHAO, Xiang-yang LUO, Fen-lin LIU
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source