Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor [PDF]
Journal of Neuroinflammation, 2018 Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang +12 more
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Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions [PDF]
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
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DREAM regulates BDNF-dependent spinal sensitization [PDF]
Molecular Pain, 2010 Background The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) controls the expression of prodynorphin and has been involved in the modulation of endogenous responses to pain.
Mellström Britt +9 more
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Sub-chronic stress exerts partially distinct behavioral and epigenetic effects in male and female mice [PDF]
Frontiers in Behavioral NeuroscienceIntroductionStress-related disorders, such as major depression, anxiety disorders, and post-traumatic stress disorder, lead to considerable disease burden and are notoriously difficult to treat.
Matthew J. Domanico +6 more
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Estrogen promotes gonadotropin-releasing hormone expression by regulating tachykinin 3 and prodynorphin systems in chicken [PDF]
Poultry Science: The “KNDy neurons” located in the hypothalamic arcuate nucleus (ARC) of mammals are known to co-express kisspeptin, neurokinin B (NKB), and dynorphin (DYN), and have been identified as key mediators of the feedback regulation of steroid hormones on ...
Xing Wu +18 more
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions [PDF]
Molecular MetabolismObjective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells.
Miranda Movahed +2 more
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Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep [PDF]
Neurology InternationalBackground/Objectives: The circadian regulator, circadian locomotor output cycles kaput (CLOCK), is well-established in maintaining sleep–wake rhythms, yet its cell-type-specific functions in sleep regulation remain largely unexplored. While ventromedial
Ting He, Xu Wang
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Neurexin 3 Regulates Synaptic Connections Between Central Amygdala Neurons and Excitable Cells of the Lateral Parabrachial Nucleus in Rats with Varicella Zoster Induced Orofacial Pain [PDF]
Journal of Pain ResearchPhillip R Kramer,1 Rebecca S Hornung,1 Mikhail Umorin,1 M Douglas Benson,1 Paul R Kinchington2 1Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA; 2Department of Ophthalmology and of Molecular Microbiology and ...
Kramer PR +4 more
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Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex [PDF]
Cells(1) Background: The effects of short-term social isolation during adulthood have not yet been fully established in rats behaviourally, and not at all transcriptomically in the medial prefrontal cortex (mPFC).
Vivien Csikós +7 more
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Molecules, 2021 Neuropeptides serve as neurohormones and local paracrine regulators that control neural networks regulating behavior, endocrine system and sensorimotor functions. Their expression is characterized by exceptionally restricted profiles.
Olga Nosova +4 more
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