Results 11 to 20 of about 4,556 (199)

Dysregulated Plasticity in Serotonin, Galanin, and Opioid Systems Contributes to Limbic Seizure Recruitment in Wistar Audiogenic Rat. [PDF]

J Neurochem
To find molecular reasons why a genetic rat model (Wistar Audiogenic Rat, WAR) moves from sound‐triggered brainstem seizures to longer‐lasting limbic (temporal‐lobe) epilepsy after repeated loud‐noise exposure. WAR and normal Wistar rats received a 10‐day audiogenic kindling (twice‐daily loud noise).
Camilo TA, Valentim-Lima E, de Oliveira JAC, Garcia-Cairasco N, Reis LC, Nani JV, de Souza Mecawi A.   +6 more
europepmc   +2 more sources

Whole‐brain cell‐cell interaction patterns explain tissue damage in several neurodegenerative conditions [PDF]

Alzheimers Dement
Abstract Background Disrupted interactions among neurons, glial and vascular cell types can lead to inflammation, vascular dysfunction, and neuronal death, highlighting the need to understand how functional interactions between these cells predispose the development of different neurodegenerative conditions.
Pak V, Hong J, Bezgin G, Dadar M, Zeighami Y, Medina Y.   +5 more
europepmc   +4 more sources

Behavioural characterization of prodynorphin knockout mice [PDF]

BMC Pharmacology, 2008
Dynorphin, with a high selectivity for kappa opioid receptors, is a member of the opioid peptide family. Application of opioid agonists and antagonists revealed crucial effects of the opioid system in numerous physiological functions. However, data obtained are often contradictive, reflecting the complex situation of the cross-activation of 3 receptors
Eduard Schunk, Iris Rosskothen, Walter Wittmann, Stefano Gaburro, Nicolas Singewald, Herbert Herzog, Christoph Schwarzer   +6 more
core   +3 more sources

Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance. [PDF]

Addict Biol
We examined the optimum parameters for producing conditioned place avoidance (CPA) to the acutely aversive effects of cocaine treatment. We discovered that individual differences, rather than cocaine dose, apparatus type, stimulus modality or conditioning time, were important for expression of cocaine CPA.
Nicot A, Yecham P, Serin I, Barker DJ, Dobbs LK.   +4 more
europepmc   +2 more sources

Short Tandem Repeat Variation in the CNR1 Gene Associated With Analgesic Requirements of Opioids in Postoperative Pain Management

Frontiers in Genetics, 2022
Short tandem repeats (STRs) and variable number of tandem repeats (VNTRs) that have been identified at approximately 0.7 and 0.5 million loci in the human genome, respectively, are highly multi-allelic variations rather than single-nucleotide ...
Shinya Kasai, Daisuke Nishizawa, Junko Hasegawa, Ken-ichi Fukuda, Tatsuya Ichinohe, Makoto Nagashima, Masakazu Hayashida, Kazutaka Ikeda   +7 more
doaj   +1 more source

Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice

Frontiers in Neural Circuits, 2022
The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Ayako Maegawa, Ayako Maegawa, Koshi Murata, Koshi Murata, Kazuki Kuroda, Kazuki Kuroda, Shigeharu Fujieda, Yugo Fukazawa, Yugo Fukazawa, Yugo Fukazawa   +9 more
doaj   +1 more source

Characterization of the Rat Prodynorphin Gene [PDF]

Molecular Endocrinology, 1989
The structure of full-length rat prodynorphin cDNA and the corresponding gene has been determined. The 2400 base rat prodynorphin mRNA is encoded by four exons. Exons 1 and 2 encode the majority of the 5'-untranslated sequence, while exons 3 and 4 contain the translated region; the entire 3' -untranslated region is contained on exon 4 as well.
J, Douglass, C T, McMurray, J E, Garrett, J P, Adelman, L, Calavetta   +4 more
openaire   +2 more sources

Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses

eLife, 2021
Maintaining stable body temperature through environmental thermal stressors requires detection of temperature changes, relay of information, and coordination of physiological and behavioral responses. Studies have implicated areas in the preoptic area of
Aaron J Norris, Jordan R Shaker, Aaron L Cone, Imeh B Ndiokho, Michael R Bruchas   +4 more
doaj   +1 more source

Prodynorphin peptide immunocytochemistry in rhesus monkey brain [PDF]

Peptides, 1985
The present study describes the immunocytochemical distribution of peptides derived from the prodynorphin precursor in the brain of the rhesus monkey (Macaca mulatta). Animals were treated with colchicine (intracerebroventricularly) prior to perfusion to enhance the observation of perikaryal immunoreactivity.
Khachaturian, Henry, Lewis, Michael E., Haber, Suzanne N., Houghten, Richard A., Akil, Huda, Watson, Stanley J.   +5 more
openaire   +3 more sources

SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]

BAG. Journal of Basic and Applied Genetics, 2020
Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F., Castellote M.A., Corva P.M.   +2 more
doaj   +1 more source