Evolution of Proenkephalin and Prodynorphin [PDF]
American Zoologist, 1986 SYNOPSIS. Since the discovery of the enkephalins in 1975, three separate families of opioid peptides have been identified, proopiomelanocortin, proenkephalin, and prodynorphin. The lattertwo have multiple copies of the enkephalin sequence in larger enkephalin containing polypeptides (ECPs).
RANDOLPH V. LEWIS, BRUCE W. ERICKSON
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Effect of PDYN rs2281285, rs2235749 and rs910080 gene polymorphisms on the intensity of depression symptoms and negative craving in heroin addicts [PDF]
Archives of Biological Sciences, 2021 The present study was undertaken to explore whether prodynorphin (PDYN) polymorphisms have an effect on the intensity of depressive symptoms and negative craving in heroin addicts in a sample of 100 heroin addicts and 108 controls.
Kaya-Akyüzlü Dilek +3 more
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eLife, 2020 Maladaptive responses to stress are a hallmark of alcohol use disorder, but the mechanisms that underlie this are not well characterized. Here, we show that kappa opioid receptor signaling in the bed nucleus of the stria terminalis (BNST) is a critical ...
Lara S Hwa +11 more
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Molecular mechanisms underlying increased PDYN and dynorphin expression in the prefrontal cortex of alcoholic men [PDF]
, 2011 Alcohol dependence is a chronic relapsing disorder caused by drug x gene x environment interactions for which pharmacotherapy is but moderately effective.
Henriksson, Richard
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Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]
, 2017 Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar +15 more
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Neurobiology of Disease, 1999 Rats with unilateral dopamine-denervating lesions sustained a 3-week treatment with a daily l-DOPA dose that is in the therapeutic range for Parkinson's disease.
M. Andersson, A. Hilbertson, M.A. Cenci
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Ancient and recent positive selection transformed opioid cis-regulation in humans.
PLoS Biology, 2005 Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking.
Matthew V Rockman +5 more
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Preserving Neuronal Chemical Messengers: Heat Stabilization Versus Snap Freezing for Improved MALDI Mass Spectrometry Imaging of Brain Tissues. [PDF]
J NeurochemRapid heat stabilization of brain tissue preserves the natural levels and spatial distribution of neurotransmitters and neuropeptides better than traditional snap freezing. Using matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI), we show that heat stabilization effectively prevents postmortem enzymatic degradation ...
Salviati E +7 more
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Regulation of striatonigral prodynorphin peptides by dopaminergic agents [PDF]
Brain Research, 1990 The primary purpose of this study was to examine the regulation of prodynorphin peptides by dopaminergic agents in the central nervous system. The indirectly acting catecholamine agonist D-amphetamine sulfate (AMPH) and the dopamine receptor antagonist haloperidol (HAL) were administered to rats across a variety of treatment schedules and drug doses ...
Trujillo, Keith A. +2 more
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Influence of sex and genetic background on anxiety-related and stress-induced behaviour of prodynorphin-deficient mice. [PDF]
PLoS ONE, 2012 The role of dynorphin/kappa opioid receptors in epilepsy and addiction are well accepted, but their function in emotional control is not yet fully understood.
Iris Kastenberger +3 more
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