Results 61 to 70 of about 4,556 (199)
Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides
Biomedicines, 2021 Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb +6 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2015 Whether the opioid system plays a role in the ability to flexibly adapt behavior is still unclear. We used fMRI to investigate the effect of a nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin gene on cerebral activation ...
Mikhail eVotinov +7 more
doaj +1 more source
Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. [PDF]
PLoS ONE, 2014 Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction.
Ami Cohen +7 more
doaj +1 more source
Prodynorphin-derived peptide expression in primate cortex and striatum [PDF]
Neuropeptides, 1994 The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum.
Healy, Daniel J. +1 more
openaire +3 more sources
Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.Abstract BACKGROUND Depressive symptoms are common in cognitive decline and Alzheimer's disease (AD), but their underlying pathology remains poorly understood. We aimed to investigate the pathophysiology of depressive symptoms in the context of AD. METHODS Individuals with normal cognition (NC), mild cognitive impairment (MCI), or mild AD dementia from
Miriam Rabl +17 more
wiley +1 more source
PLoS ONE, 2011 L-DOPA-induced dyskinesia is a troublesome complication of L-DOPA pharmacotherapy of Parkinson's disease and has been associated with disturbed brain opioid transmission.
Anna Ljungdahl +4 more
doaj +1 more source
BMC Neuroscience, 2010 Background Neuroplasticity induced by neonatal inflammation is the consequence of a combination of activity-dependent changes in neurons. We investigated neuronal sensitivity to a noxious stimulus in a rat model of neonatal hind-paw peripheral ...
Wen Yeong-Ray +7 more
doaj +1 more source
A Novel Excitatory Paraventricular Nucleus to AgRP Neuron Circuit that Drives Hunger [PDF]
, 2014 Summary Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to its control.
Garfield, Alastair S. +11 more
core +1 more source
Sequence and expression of the rat prodynorphin gene. [PDF]
Proceedings of the National Academy of Sciences, 1985 We report here the isolation of a lambda genomic clone that contains the nucleotide sequence coding for the main exon of the rat prodynorphin (proenkephalin B) gene. This exon codes for the majority of the translated region of prodynorphin mRNA including the opioid peptides alpha-neo-endorphin, dynorphin A, and dynorphin B.
O, Civelli +3 more
openaire +2 more sources
The sweet drive test : refining phenotypic characterization of anhedonic behavior in rodents [PDF]
, 2014 Measuring anhedonic behavior in rodents is a challenging task as current methods display only moderate sensitivity to detect anhedonic phenotype and, consequently, results from different labs are frequently incongruent.
Ana Rita Machado-Santos +15 more
core +2 more sources