Results 21 to 30 of about 11,013,611 (366)

Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy

Frontiers in Medicine, 2022
Duchenne muscular dystrophy (DMD) is an X-linked hereditary disease characterized by progressive muscle wasting due to modifications in the DMD gene (exon deletions, nonsense mutations, intra-exonic insertions or deletions, exon duplications, splice site
Cedric Happi Mbakam, Cedric Happi Mbakam, Gabriel Lamothe, Gabriel Lamothe, Jacques P. Tremblay, Jacques P. Tremblay   +5 more
doaj   +1 more source

Maintenance of Neural Progenitor Cell Stemness in 3D Hydrogels Requires Matrix Remodeling

Nature Materials, 2017
Neural progenitor cell (NPC) culture within 3D hydrogels is an attractive strategy for expanding a therapeutically-relevant number of stem cells. However, relatively little is known about how 3D material properties such as stiffness and degradability ...
C. Madl, Bauer L. LeSavage, Ruby E. Dewi, Cong-binh Dinh, Ryan Stowers, Margarita Khariton, Kyle J. Lampe, Duong Nguyen, Ovijit Chaudhuri, A. Enejder, S. Heilshorn   +10 more
semanticscholar   +1 more source

Hepatic stellate cell progenitor cells [PDF]

Journal of Gastroenterology and Hepatology, 2012
AbstractHepatic stellate cells (HSCs) are recognized as a major player in liver fibrogenesis. Upon liver injury, HSCs differentiate into myofibroblasts and participate in progression of fibrosis and cirrhosis. Additional cell types such as resident liver fibroblasts/myofibroblasts or bone marrow cells are also known to generate myofibroblasts.
openaire   +2 more sources

Neural Progenitor Cell Terminology [PDF]

Frontiers in Neuroanatomy, 2018
Since descriptions of neural precursor cells (NPCs) were published in the late 19th century, neuroanatomists have used a variety of terms to describe these cells, each term reflecting contemporary understanding of cellular characteristics and function. As the field gained knowledge through a combination of technical advance and individual insight, the ...
Verónica Martínez-Cerdeño, Verónica Martínez-Cerdeño, Stephen C. Noctor, Stephen C. Noctor   +3 more
openaire   +5 more sources

Redirection of Human Cancer Cells upon the Interaction with the Regenerating Mouse Mammary Gland Microenvironment

Cells, 2013
Tumorigenesis is often described as a result of accumulated mutations that lead to growth advantage and clonal expansion of mutated cells. There is evidence in the literature that cancer cells are influenced by the microenvironment.
Sonia M. Rosenfield, Gilbert H. Smith
doaj   +1 more source

Mobilizing Endothelial Progenitor Cells [PDF]

Hypertension, 2005
Mobilization of endogenous endothelial progenitor cells (EPCs) from the bone marrow may be an alternative way to increase neovascularization and may be used as therapeutic option for the treatment of ischemic cardiovascular diseases. In this review, we discuss the EPC mobilizing effects of pro-inflammatory cytokines such as granolocyte monocyte colony ...
Alexandra, Aicher, Andreas M, Zeiher, Stefanie, Dimmeler   +2 more
openaire   +2 more sources

Joint Development Involves a Continuous Influx of Gdf5-Positive Cells

Cell Reports, 2016
Synovial joints comprise several tissue types, including articular cartilage, the capsule, and ligaments. All of these compartments are commonly assumed to originate from an early set of Gdf5-expressing progenitors populating the interzone domain.
Yulia Shwartz, Sergey Viukov, Sharon Krief, Elazar Zelzer   +3 more
doaj   +1 more source

Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement

Nature Communications, 2018
Formation and segregation of cell lineages forming the heart have been studied extensively but the underlying gene regulatory networks and epigenetic changes driving cell fate transitions during early cardiogenesis are still only partially understood ...
Guangshuai Jia, J. Preussner, Xi Chen, S. Guenther, Xuejun Yuan, Michail Yekelchyk, C. Kuenne, M. Looso, Yonggang Zhou, S. Teichmann, T. Braun   +10 more
semanticscholar   +1 more source

Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Mesenchymal progenitor cells play important roles in the formation of skeletal tissues; however, how cell fates of mesenchymal progenitor cells are regulated remains largely unclear.
A. Takahashi, M. Nagata, Aditi Gupta, Yuki Matsushita, Tetsutaro Yamaguchi, Koji Mizuhashi, K. Maki, A. Ruellas, L. Cevidanes, H. Kronenberg, N. Ono, W. Ono   +11 more
semanticscholar   +1 more source

Myocardial Ischemia and Mobilization of Circulating Progenitor Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe response of progenitor cells (PCs) to transient myocardial ischemia in patients with coronary artery disease remains unknown. We aimed to investigate the PC response to exercise‐induced myocardial ischemia (ExMI) and compare it to flow ...
Muhammad Hammadah, Ayman Samman Tahhan, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Bryan R. Kindya, Heval M. Kelli, Wesley T. O'Neal, Pratik Sandesara, Samaah Sullivan, Zakaria Almuwaqqat, Malik Obideen, Naser Abdelhadi, Ayman Alkhoder, Pratik M. Pimple, Oleksiy Levantsevych, Kareem H. Mohammed, Lei Weng, Laurence S. Sperling, Amit J. Shah, Yan V. Sun, Brad D. Pearce, Michael Kutner, Laura Ward, J. Douglas Bremner, Jinhee Kim, Edmund K. Waller, Paolo Raggi, David Sheps, Viola Vaccarino, Arshed A. Quyyumi   +30 more
doaj   +1 more source