Results 1 to 10 of about 2,512,088 (315)
Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility
Endocrine reviews, 2020 Selective progesterone receptor modulators (SPRMs) are a new class of compounds developed to target the progesterone receptor (PR) with a mix of agonist and antagonist properties.
M. Islam +3 more
semanticscholar +1 more source
Human Reproduction Update, 2020 BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in general and progestins in particular sometimes fail in endometriosis.
F. Reis +5 more
semanticscholar +1 more source
Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. [PDF]
PLoS ONE, 2011 Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development.
Jarom Heijmans +11 more
doaj +1 more source
The Neandertal Progesterone Receptor
Molecular biology and evolution, 2020 The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense ...
H. Zeberg, J. Kelso, S. Pääbo
semanticscholar +1 more source
The importance of simultaneous determination of breast cancer biomarkers [PDF]
Archive of Oncology, 2002 It is shown that steroid hormone receptors by themselves are not sufficiently strong prognostic factors in management of breast cancer. For that reason, simultaneous consideration of different biomarkers seems to be more appropriate for clinical use, i.e.
Markićević Milan +3 more
doaj +1 more source
A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer
International Journal of Molecular Sciences, 2023 Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hormone
Léa Clusan +3 more
semanticscholar +1 more source
A novel therapeutic approach for treatment of catamenial epilepsy
Neurobiology of Disease, 2018 Many women with epilepsy experience perimenstrual seizure exacerbation, referred to as catamenial epilepsy. There is no effective treatment for this condition, proposed to result from withdrawal of neurosteroid-mediated effects of progesterone.
Suchitra Joshi +5 more
doaj +1 more source
The Effect of Imbalanced Progesterone Receptor-A/-B Ratio on Gelatinase Expressions in Endometriosis [PDF]
International Journal of Fertility and Sterility, 2019 Background Gelatinases degrade extracellular matrix (ECM) components to allow for physiological remodeling and contribute to pathological tissue destruction in endometriosis.
Sepideh Mousazadeh +4 more
doaj +1 more source
Estrogen and progesterone receptor expression in breast carcinoma
Journal of Pathology of Nepal, 2011 Background: Breast carcinoma is the most common malignancy diagnosed among women worldwide and second leading cause of cancer mortality. One of the hallmarks of the disease is expression of estrogen receptor and progesterone receptor that ultimately ...
TB Pathak +7 more
doaj +1 more source
Pathological implication of progesterone receptor expression in patients diagnosed with meningioma [PDF]
Romanian Journal of NeurologyObjectives. To assess the progesterone receptor expression in meningioma patients and to characterize the histopathological and demographic features of them. Materials and methods.
Murooj Jassim Mohammed +3 more
doaj +1 more source