Results 1 to 10 of about 2,591,762 (410)

The Neandertal Progesterone Receptor [PDF]

Molecular Biology and Evolution, 2020
Abstract The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense substitutions and a mobile Alu element.
Janet Kelso, Svante Pääbo, Svante Pääbo, Hugo Zeberg, Hugo Zeberg   +4 more
openaire   +4 more sources

Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth. [PDF]

PLoS ONE, 2013
A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the ...
Steven M Yellon, Abigail E Dobyns, Hailey L Beck, James T Kurtzman, Robert E Garfield, Michael A Kirby   +5 more
doaj   +2 more sources

Establishment of a graphene quantum dot (GQD) based steroid binding assay for the nuclear progesterone receptor (pgr) [PDF]

Biochemistry and Biophysics Reports
Previously, we established a homogeneous assay for membrane progesterone receptor alpha (mPRα) ligands by conjugating semiconductor nanoparticles known as graphene quantum dots (GQDs) to mPRα. When mixed with a progesterone-BSA-fluorescein isothiocyanate
Md. Forhad Hossain, Shakhawat Hossain, Md. Maisum Sarwar Jyoti, Yuki Omori, Saokat Ahamed, Toshinobu Tokumoto   +5 more
doaj   +2 more sources

Expression of Progesterone Receptor and Its Association with Clinicopathological Characteristics in Meningiomas: A Cross-Sectional Study

World Neurosurgery: X, 2021
Background: Meningiomas that are progesterone receptor positive have a low recurrence rate and good prognosis compared to those that are progesterone receptor negative.
Leah Mnango, Angela Mwakimonga, Advera I. Ngaiza, James J. Yahaya, Edda Vuhahula, Amos R. Mwakigonja   +5 more
doaj   +1 more source

Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins. [PDF]

PLoS ONE, 2014
Progesterone withdrawal is essential for parturition, but the mechanism of this pivotal hormonal change is unclear in women and other mammals that give birth without a pre-labor drop in maternal progesterone levels.
Toni N Welsh, Jonathan J Hirst, Hannah Palliser, Tamas Zakar   +3 more
doaj   +1 more source

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Beer, Bergeron, Bertrand, Bielefeldt, Blackmore, Breit, Cahalan, Cahalan, Chandy, Clemens, Crabtree, Dolmetsch, Fiering, Foresta, Gouy, Grissmer, Grynkiewicz, Gurka, Hamill, Hess, Horn, Hunt, Karttunen, Kerschbaum, Koo, Lewis, Lewis, Lin, Logsdon, Mason, Michne, Monterroso, Negulescu, Nguyen, Pavia, Pepe, Phipps, Premack, Price, Revelli, Roussev, Runnebaum, Runnebaum, Shastri, Siiteri, Siiteri, Stites, Thastrup, Timmerman, Valera, Van Voorhis, Verheugen, Waldegger, Wu, Zweifach   +54 more
core   +3 more sources

Progesterone Signaling and Mammalian Ovarian Follicle Growth Mediated by Progesterone Receptor Membrane Component Family Members

Cells, 2022
How progesterone influences ovarian follicle growth is a difficult question to answer because ovarian cells synthesize progesterone and express not only the classic nuclear progesterone receptor but also members of the progestin and adipoQ receptor ...
John J. Peluso
doaj   +1 more source

Reproductive functions of the progesterone receptor [PDF]

Journal of the Society for Gynecologic Investigation, 2000
The steroid hormone progesterone plays a central role in the reproductive events associated with pregnancy establishment and maintenance. Physiological effects of progesterone are mediated by interaction of the hormone with specific intracellular progesterone receptors (PRs) that are expressed as two protein isoforms, PR-A and PR-B. Both proteins arise
Bert W. O'Malley, John P. Lydon, Biserka Mulac-Jericevic, Francesco J. DeMayo, Orla M. Conneely   +4 more
openaire   +4 more sources

Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. [PDF]

PLoS ONE, 2011
Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development.
Jarom Heijmans, Vanesa Muncan, Rutger J Jacobs, Eveline S M de Jonge-Muller, Laura Graven, Izak Biemond, Antwan G Ederveen, Patrick G Groothuis, Sietse Mosselman, James C Hardwick, Daniel W Hommes, Gijs R van den Brink   +11 more
doaj   +1 more source

The importance of simultaneous determination of breast cancer biomarkers [PDF]

Archive of Oncology, 2002
It is shown that steroid hormone receptors by themselves are not sufficiently strong prognostic factors in management of breast cancer. For that reason, simultaneous consideration of different biomarkers seems to be more appropriate for clinical use, i.e.
Markićević Milan, Todorović-Raković Nataša, Kanjer Ksenija, Nikolić-Vukosavljević Dragica   +3 more
doaj   +1 more source