Results 121 to 130 of about 2,591,762 (410)

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive Biology and Endocrinology, 2006
Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on various ...
Slayden Ov, Brenner Robert, Garg Ramesh, Chwalisz Kristof, Winkel Craig, Elger Walter   +5 more
doaj   +1 more source

Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells [PDF]

, 2005
Interactions between steroid hormone receptors and signal transducer and activator of transcription (Stat)-mediated signaling pathways have already been described.
Carnevale, Romina Paula, Charreau, Eduardo Hernan, Elizalde, Patricia Virginia, Frahm, Isabel, Kornblihtt, Alberto Rodolfo, Molinolo, Alfredo, Pecci, Adali, Proietti Anastasi, Cecilia Jazmín, Rosemblit, Cinthia, Salatino, Mariana, Schillaci, Roxana   +10 more
core   +3 more sources

Senescence‐Inducing Therapy Sequential NIR‐II Mild Photothermal/Senolytic Therapy of Triple Negative Breast Cancer

Advanced Science, EarlyView.
Targeting triple‐negative breast cancer remains challenging due to limited therapies and drug resistance. A sequential theranostic strategy combining palbociclib‐induced senescence (enhancing heat sensitivity via HSP70 downregulation) with an NIR‐II nanoplatform (IQ NPs) for mild photothermal therapy (PTT) and quercetin‐mediated senolysis is developed.
Liya Yu, Yehui Kang, Mengdie Yu, Yuejia Ding, Yang Chen, Qingyuan Wu, Yu Cai, Huiyu Liu, Zhenye Lv   +8 more
wiley   +1 more source

Characterization and ligand identification of a membrane progesterone receptor in fungi: existence of a novel PAQR in Sporothrix schenckii

BMC Microbiology, 2012
Background Adaptive responses in fungi result from the interaction of membrane receptors and extracellular ligands. Many different classes of receptors have been described in eukaryotic cells. Recently a new family of receptors classified as belonging to
Gonzalez-Velazquez Waleska, Gonzalez-Mendez Ricardo, Rodriguez-del Valle Nuri   +2 more
doaj   +1 more source

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source

Myometrial progesterone hyper-responsiveness associated with increased risk of human uterine fibroids

BMC Women's Health, 2019
Background Uterine Fibroids (UFs) growth is ovarian steroid-dependent. Previous studies have shown that estrogen and progesterone play an important role in UF development.
Mona Omar, Archana Laknaur, Ayman Al-Hendy, Qiwei Yang   +3 more
doaj   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors

Brazilian Oral Research, 2009
The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands ...
Fabio Augusto Ito, Kazuhiro Ito, Ricardo Della Coletta, Pablo Agustín Vargas, Márcio Ajudarte Lopes   +4 more
doaj   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

BPA-Induced Deregulation of Epigenetic Patterns: Effects on Female Zebrafish Reproduction [PDF]

, 2016
Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms.
Carnevali, Oliana, Cobellis, Gilda, DALLA VALLE, Luisa, Gioacchini, Giorgia, Maradonna, Francesca, Piccinetti, Chiara Carla, Santangeli, Stefania   +6 more
core   +1 more source