Results 291 to 300 of about 4,627,535 (339)

Progesterone receptor and the mechanism of action of progesterone antagonists

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Currently available progesterone antagonists have been suggested to fall into two categories based on differences in how they interact with and inactivate the progesterone receptor (PR). The anti-progestin ZK98299 (Type I) impairs PR association with DNA, while Type II compounds (RU486, ZK112993, ZK98734) promote PR binding to DNA.
D P, Edwards, M, Altmann, A, DeMarzo, Y, Zhang, N L, Weigel, C A, Beck   +5 more
openaire   +2 more sources

American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer

Archives of Pathology & Laboratory Medicine, 2010
Purpose To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers.
M. Hammond, Daniel F. Hayes, M. Dowsett, D. C. Allred, Karen L. Hagerty, S. Badve, P. Fitzgibbons, G. Francis, N. Goldstein, M. Hayes, David G. Hicks, S. Lester, R. Love, Pamela B. Mangu, L. McShane, K. Miller, C. Osborne, S. Paik, J. Perlmutter, A. Rhodes, H. Sasano, Jared N. Schwartz, F. C. G. Sweep, S. Taube, E. Torlakovic, P. Valenstein, G. Viale, D. Visscher, T. Wheeler, R. B. Williams, J. Wittliff, Antonio C. Wolff   +31 more
semanticscholar   +1 more source

Progesterone Receptors and Ovulation

2010
The steroid hormone, progesterone, plays a critical role in the regulation of female ovulation. The physiological effects of progesterone are mediated by two nuclear receptor transcription factors, PR-A and PR-B, which are produced from a single gene and upon binding progesterone regulate the expression of specific gene networks in reproductive tissues.
openaire   +2 more sources

Progesterone antagonists and progesterone receptor modulators: an overview

Steroids, 2003
Since the original description of the structure of the antiprogestin, mifepristone, was published, numerous related compounds have been synthesized which may function as progesterone antagonists (PAs) or progesterone receptor modulators (PRMs). The latter are mixed agonists-antagonists.
openaire   +2 more sources

Progesterone ”Receptor“ in Rat Ovary*

Endocrinology, 1979
A soluble thermolabile protein with many characteristics of a progesterone receptor has been identified in ovaries of estrogen-stimulated, hypophysectomized, immature female rats. A potent synthetic progestin R5020 (17,21-dimethyl-19-nor-pregna-4, 9-diene-3, 20-dione) and a progestin-receptor complex stabilizer (glycerol) were employed.
J R, Schreiber, J W, Hsueh
openaire   +2 more sources

Progesterone Receptors in Rat Thymus

Endocrinology, 1983
Tritiated promegestone ([3H]R5020) is bound with high affinity in cytosol prepared from the thymus gland of both male and female rats. To prevent tracer binding to glucocorticoid receptors, we have used excess RU26988 (11 beta, 17 beta-dihydroxy-21-methyl-17 alpha-pregna-1,4,6-trien-20-yn-3-one), a highly specific synthetic glucocorticoid.
P T, Pearce, B A, Khalid, J W, Funder
openaire   +2 more sources

Progesterone and the progesterone receptor.

The Journal of reproductive medicine, 2001
During the 1990s, extensive research has effectively mapped the progesterone receptor-mediated actions of progesterone and has more recently uncovered nonreceptor-mediated effects--the effect of progesterone on uterine sensitivity to oxytocin, for example, involves direct, nongenomic progesterone action on the uterine oxytocin receptor.
openaire   +1 more source

Activation of Progesterone Receptor by ATP

European Journal of Biochemistry, 1981
Progesterone-receptor complex from freshly prepared hen oviduct cytosol acquired the ability to bind to isolated nuclei, DNA-cellulose and ATP-Sepharose when incubated with 5-10 mM ATP at 4 degrees C. The extent of this ATP-dependent activation was higher when compared with heat-activation achieved by warming the progesterone-receptor complex at 23 ...
V, Moudgil, V, Kruczak, T, Eessalu, C S, Paulose, M, Taylor, J, Hansen   +5 more
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Estrogen and progesterone receptors in meningiomas

Journal of Neurosurgery, 1984
✓ Two-thirds of all meningiomas and four-fifths of intraspinal and sphenoidal meningiomas occur in women. Meningiomas frequently enlarge or become symptomatic during pregnancy or during the luteal phase of the menstrual cycle. There is an increased incidence of meningiomas in women with breast carcinoma. In a series of 23 patients with meningiomas, the
D W, Cahill, N, Bashirelahi, L W, Solomon, T, Dalton, M, Salcman, T B, Ducker   +5 more
openaire   +2 more sources

Structural analyses of progesterone receptors

Journal of Steroid Biochemistry, 1986
Progesterone receptors of T47Dco human breast cancer cells consist of two equimolar hormone-binding proteins of mol. wt approximately 85,000 (A protein) and 115,000 (B protein). Both proteins can be demonstrated in intact cells by in situ photoaffinity labeling; that is, in cells treated with the synthetic progestin [3H]R5020, irradiated 2 min with 300
K B, Horwitz, L L, Wei, M D, Francis
openaire   +2 more sources