Results 31 to 40 of about 2,512,088 (315)

Progesterone differentially affects the transcriptomic profiles of cow endometrial cell types

BMC Genomics, 2022
Background The endometrium is a heterogeneous tissue composed of luminal epithelial (LE), glandular epithelial (GE), and stromal cells (ST), experiencing progesterone regulated dynamic changes during the estrous cycle.
Gonçalo Pereira, Yongzhi Guo, Elisabete Silva, Claudia Bevilacqua, Gilles Charpigny, Luís Lopes-da-Costa, Patrice Humblot   +6 more
doaj   +1 more source

Effect of Bengkoang (Pachyrhizus erosus) Extract on Estrogen Receptor-?, Progesterone Receptor Expression, and Follicle-Stimulating Hormone Levels

Indonesian Journal of Obstetrics and Gynecology
Objective: Progesterone functions by inhibiting the release of Gonadotropin-Releasing Hormone (GnRH), which decreases Follicle-Stimulating Hormone (FSH) levels and converts them into hypoestrogens.
Suryanti, Mayasari Putri Ardela, Eka Frenty Hadiningsih, Sri Winarsih, Noorhamdani, Tatit Nurseta, Eviana Norahmawati   +6 more
doaj   +1 more source

Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats

Scientific Reports, 2017
Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse frequency. Recent studies reported that progesterone prevented premature LH surges during ovarian hyperstimulation in women. As the most potent stimulator of GnRH/LH release,
Wen He, Xiaofeng Li, Daniel Adekunbi, Yali Liu, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang, Kevin T. O’Byrne   +8 more
doaj   +1 more source

Hormonal modulators of glial ABCA1 and apoE levels[S]

Journal of Lipid Research, 2013
Apolipoprotein E (apoE) is the major lipid carrier in the central nervous system. As apoE plays a major role in the pathogenesis of Alzheimer disease (AD) and also mediates repair pathways after several forms of acute brain injury, modulating the ...
Jianjia Fan, Yoko Shimizu, Jeniffer Chan, Anna Wilkinson, Ayaka Ito, Peter Tontonoz, Edie Dullaghan, LiisaA.M. Galea, Tom Pfeifer, Cheryl L. Wellington   +9 more
doaj   +1 more source

The rate of estrogen receptor‐conversion associated with tumor progression in estrogen receptor‐positive breast cancer patients following adjuvant Tamoxifen administration

Cancer Reports, 2022
Background Hormone Receptor (HR)‐discordance between primary breast cancer and metastasis is a known biological phenomenon. Discordance studies usually comprise a heterogeneous group of HR‐positive and negative patients and allow for the comparison of ...
Sirus Djahansouzi, Bettina Hanstein, Daniel Rein, Michel Clees, Werner Rath   +4 more
doaj   +1 more source

Genetic polymorphisms in eostrogen and progesterone receptor genes in Papio anubis induced with endometriosis during early stage of the disease

AIMS Molecular Science, 2021
Genetic predisposition has been suggested to play a role in the pathogenesis of endometriosis. The most common pathogenetic hypotheses is that there is possible dysregulation of the ligand-receptorial signaling involving the main sex hormones, eostrogen ...
Irene M. Waita, Atunga Nyachieo , Daniel Chai, Samson Muuo, Naomi Maina , Daniel Kariuki , Cleophas M. Kyama   +6 more
doaj   +1 more source

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

Genes & Development, 1995
Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to have a functional role in a number of other reproductive events.
J. Lydon, C. Funk, Shiala K. Mani, Angela R. Hughes, G. Shyamala, Orla M. Connee ly   +5 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function

Cell Reports, 2016
Summary: Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantation ...
Cory A. Rubel, San-Pin Wu, Lin Lin, Tianyuan Wang, Rainer B. Lanz, Xilong Li, Ramakrishna Kommagani, Heather L. Franco, Sally A. Camper, Qiang Tong, Jae-Wook Jeong, John P. Lydon, Francesco J. DeMayo   +12 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source