Results 71 to 80 of about 134,438 (269)

Establishment of a graphene quantum dot (GQD) based steroid binding assay for the nuclear progesterone receptor (pgr)

Biochemistry and Biophysics Reports
Previously, we established a homogeneous assay for membrane progesterone receptor alpha (mPRα) ligands by conjugating semiconductor nanoparticles known as graphene quantum dots (GQDs) to mPRα. When mixed with a progesterone-BSA-fluorescein isothiocyanate
Md. Forhad Hossain, Shakhawat Hossain, Md. Maisum Sarwar Jyoti, Yuki Omori, Saokat Ahamed, Toshinobu Tokumoto   +5 more
doaj   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Current status of estrogen and progesterone receptors in breast cancer [PDF]

, 1977
William McGuire, Kathryn B. Horwitz, Olof H. Pearson, A Segaloff   +3 more
openalex   +1 more source

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen, Gunjan Chauhan, Surbhi Soni, Monika Vats, Anand Kumar, Indra Bahadur   +5 more
wiley   +1 more source

Anti-proliferative effects of progesterone antagonists in the primate endometrium: a potential role for the androgen receptor [PDF]

, 2002
RM Brenner, OD Slayden, HO Critchley
openalex   +1 more source

Drug‐Induced Raynaud's Phenomenon and Underlying Mechanism: A Disproportionality Analysis From the World Health Organization Pharmacovigilance Database

Arthritis &Rheumatology, EarlyView.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Main factors associated with variability in the assessment of the objective response rate. A re‐analysis of the PHEREXA phase 3 clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single‐patient level the discrepancy observed by analysing ...
Gennaro Daniele, Tommaso Giovagnoli, Pierluigi Navarra, Cinzia Dello Russo   +3 more
wiley   +1 more source

Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women

Breast Cancer: Targets and Therapy, 2011
Amit V Patil1, Rahul S Bhamre2, Rajeev Singhai3, Mukund B Tayade4, Vinayak W Patil31Department of General Surgery, Government Medical College, Miraj, Maharashtra, India; 2Department of General Surgery, DY Patil Hospital and Research Centre, Nerul, Navi ...
Patil AV, Bhamre RS, Singhai R, Tayade MB, Patil VW   +4 more
doaj  

Immunolocalization of progesterone receptors in binucleate trophoblast cells of the buffalo placenta (Bubalus bubalis) [PDF]

Biotemas, 2007
The binucleate trophoblast cells (CTBs) of the water buffalo placenta (Bubalus bubalis) were studied with emphasis on the presence of progesterone receptor.
Carlos Eduardo Ambrósio, Maria Angélica Miglino, Flávia Thomaz Verechia Pereira, Celina Almeida Furlanetto Mançanares, Ana Flávia de Carvalho   +4 more
doaj  

The effects of the novel selective progesterone receptor modulator (SPRM) asoprisnil on the morphology of the reproductive tract of cycling and ovariectomized guinea pigs [PDF]

, 2004
W. Elger, G. Schubert, B. Kosub, Sandra Matz, Birgitt Schneider, Kristof Chwalisż   +5 more
openalex   +1 more source