Results 81 to 90 of about 2,591,762 (410)

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Differential expression of progesterone receptor isoforms related to PGR +331g/a polymorphism in endometriosis: A case-control study

International Journal of Reproductive BioMedicine, 2019
Background Endometriosis are defined as a progesterone-resistance disease. Two progesterone receptor (PR) isoforms, namely PR-A and PR-B, mediate the special effects of progesterone.
Sepideh Mousazadeh, Azadeh Ghaheri, Maryam Shahhoseini, Reza Aflatoonian, Parvaneh Afsharian   +4 more
doaj   +1 more source

The relationship between oestrogen receptor-alpha phosphorylation and the tumour microenvironment in patients with primary operable ductal breast cancer [PDF]

, 2017
Aims: Although the role of phosphorylation of oestrogen receptor (ER) at serines 118 (p-S118) and 167 (p-S167) has been studied, the relationship between p-S118, p-S167 and the tumour microenvironment in ER-positive primary operable ductal breast ...
Arnold, Bartlett, Brouckaert, Ciucci, Fan, Faratian, Gilchrist, Gujam, Gujam, Harvey, Jiang, Kirkegaard, Klintrup, Kok, Lannigan, Li, McCarty, Medrek, Mohammed, Mohammed, Mohammed, Mohammed, Mohammed, Mohammed, Mouridsen, Paik, Ring, Roxburgh, Salhia, Sarwar, Srinivas, Svensson, Toy, Ueno, Uzzan, Vassilakopoulou, Weitsman, Yamashita, Yamashita   +38 more
core   +1 more source

Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis [PDF]

, 2020
Atypical polypoid adenomyoma (APA) is a rare uterine lesion constituted by atypical endometrioid glands, squamous morules, and myofibromatous stroma. We aimed to assess the immunophenotype of the 3 components of APA, with regard to its pathogenesis and ...
Aggarwal, Ayhan, Chiarelli, Di Palma, Fukunaga, Giampaolino, Heatley, Horita, Houghton, Jiang, Kuwashima, Lin, Longacre, Lu, Ma, Mazur, McAlpine, McCluggage, McCluggage, Moher, Nei, Nomura, Nomura, Němejcová, Ohishi, Ota, Raffone, Raffone, Raffone, Raffone, Raffone, Raffone, Ramos, Stelloo, Strickland, Takahashi, Talhouk, Terada, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Travaglino, Young, Zhang   +46 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the Uterine Cervix

Data in Brief, 2020
A previous investigation showed that the endometrium normalized in women with endometrial hyperplasia after three months treatment with high dose levonorgestrel IUS (intrauterine system) [1]. The effect was maintained even if immunohistochemical analyses
Natalia Smaglyukova, Elise Thoresen Sletten, Anne Ørbo, Georg Sager   +3 more
doaj   +1 more source

MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology

Cells, 2022
Endometriosis is a significant disease characterized by infertility and pelvic pain in which endometrial stromal and glandular tissue grow in ectopic locations.
Warren B. Nothnick
doaj   +1 more source

Biopsy confirmation of metastatic sites in breast cancer patients:clinical impact and future perspectives [PDF]

, 2014
Determination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome,and the choice of therapy ...
A Santinelli, AJ Montero, Alastair M Thompson, AM Thompson, Angela Esposito, Aron Goldhirsch, B Weigelt, BG Mobbs, C Liedtke, C Simmons, C Tapia, CA Gomez-Roca, Carmen Criscitiello, CH Lu, D Gancberg, DS Seah, E Amir, E Amir, E Brogi, EA Mittendorf, EA Perez, EA Perez, EE Lower, EE Lower, F Andre, F André, F Liebens, Fabrice André, Franco Orsi, G Aurilio, G Bogina, G Curigliano, G Viale, Giuseppe Curigliano, HJ Chang, Ida Minchella, J Carlsson, JM Wu, L Ding, L Pusztai, LD Hoefnagel, LM Bender, LS Lindstrom, LS Steelman, Luca Fumagalli, Lucia Gelao, M Scaltriti, Marzia Locatelli, Michele De Laurentiis, MJ Higgins, N Niikura, PJ Stephens, PK Idirisinghe, R Fisher, R Simon, RJ Broom, RJ Leary, S Gupta, S Vignot, SJ Aitken, SM Edgerton, SP Shah, ST Wong, T Forshew, U Wilking, V Guarneri, W Onstenk, Y Gong, Y Nagata, YM Lo   +69 more
core   +5 more sources

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

Advanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu, Siyu Fan, Yue Zhang, Willem Woudstra, Thomas Mulder, Laurens Boscher Navarro, Jur van Dijken, Katja Loos, Romana Schirhagl   +8 more
wiley   +1 more source