Results 81 to 90 of about 2,512,088 (315)

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

Predicting MammaPrint Recurrence Risk from Breast Cancer Pathological Images Using a Weakly Supervised Transformer

Advanced Science, EarlyView.
This study presents CPMP, a weakly supervised transformer model that predicts MammaPrint recurrence risk directly from routine histopathological images of early‐stage HR+/HER2− breast cancer patients. CPMP enables spatial heatmap visualization, analysis of cellular‐level interaction patterns, and an in‐depth characterization of morphological phenotypes
Chaoyang Yan, Linwei Li, Xiaolong Qian, Yang Ou, Zhidong Huang, Zhihan Ruan, Wenting Xiang, Hong Liu, Jian Liu   +8 more
wiley   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive Biology and Endocrinology, 2006
Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on various ...
Slayden Ov, Brenner Robert, Garg Ramesh, Chwalisz Kristof, Winkel Craig, Elger Walter   +5 more
doaj   +1 more source

Characterization and ligand identification of a membrane progesterone receptor in fungi: existence of a novel PAQR in Sporothrix schenckii

BMC Microbiology, 2012
Background Adaptive responses in fungi result from the interaction of membrane receptors and extracellular ligands. Many different classes of receptors have been described in eukaryotic cells. Recently a new family of receptors classified as belonging to
Gonzalez-Velazquez Waleska, Gonzalez-Mendez Ricardo, Rodriguez-del Valle Nuri   +2 more
doaj   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Myometrial progesterone hyper-responsiveness associated with increased risk of human uterine fibroids

BMC Women's Health, 2019
Background Uterine Fibroids (UFs) growth is ovarian steroid-dependent. Previous studies have shown that estrogen and progesterone play an important role in UF development.
Mona Omar, Archana Laknaur, Ayman Al-Hendy, Qiwei Yang   +3 more
doaj   +1 more source

Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells

, 2022
Alejandro La Greca, Nicolás Bellora, François Le Dily, Rodrigo Jara, A. Silvina Nacht, Javier Quilez Oliete, José Luis Villanueva‐Cañas, Enrique Vidal, Gabriela Merino, Cristóbal Fresno, Inti Tarifa Reischle, Griselda Vallejo, Guillermo P. Vicent, Elmer A. Fernández, Miguel Beato, Patricia Saragüeta   +15 more
openalex   +2 more sources

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen, Jiajia Zhang, Junhan Ou, Ziheng Bai, Tongyan Liu, Kaiyue Zhang, Kaixiang Zhu, James Q. Wang, Chaochen Wang, Qianting Zhang, Linrong Lu, Wenwen Huang   +11 more
wiley   +1 more source