Results 11 to 20 of about 44,493 (338)

Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2018
Introduction: Endometriosis is a chronic estrogen and progestogen responsive inflammatory disease associated with pain symptoms and infertility. The medical therapy of endometriosis aims to induce decidualization within the hormonally dependent ectopic ...
Barra, Fabio, Ferrero, Simone, Scala, Carolina   +2 more
core   +2 more sources

Natural and synthetic progestins enrich cancer stem cell-like cells in hormone-responsive human breast cancer cell populations in vitro

Breast Cancer: Targets and Therapy, 2017
Sandy Goyette,1,2 Yayun Liang,1,2 Benford Mafuvadze,1,2 Matthew T Cook,1,2 Moiz Munir,1,2 Salman M Hyder1,2 1Department of Biomedical Sciences, 2Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA Abstract: Clinical trials ...
Goyette S, Liang Y, Mafuvadze B, Cook MT, Munir M, Hyder SM   +5 more
doaj   +2 more sources

Understanding Progestins: From Basics to Clinical Applicability

Journal of Clinical Medicine, 2023
Progestin is a term used to describe a synthetic progestogen. The activity and potency of synthetic progestins are mostly evaluated via parameters associated with their endometrial effects, which are related to their interactions with progesterone ...
Manuel García-Sáenz, Raúl Ibarra-Salce, Francisco Javier Pozos-Varela, Tania Sofía Mena-Ureta, Susana Flores-Villagómez, Mario Santana-Mata, Ramón G. De Los Santos-Aguilar, Daniel Uribe-Cortés, A. Ferreira-Hermosillo   +8 more
semanticscholar   +1 more source

Maribavir Pharmacokinetics and Safety in Participants With Moderate Hepatic Impairment: A Phase 1, Open‐Label, Single‐Dose, Parallel Group Study

The Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 250-258, February 2023., 2023
Abstract Maribavir, an orally bioavailable antiviral, has shown superior activity against posttransplant cytomegalovirus infection compared with conventional antivirals. It is primarily metabolized in the liver. This open‐label, single‐center study evaluated the effect of hepatic impairment on the pharmacokinetics of maribavir in nontransplant ...
Ivy Song, Grace Chen, Jingyang Wu, Katarina Ilic   +3 more
wiley   +1 more source

Therapeutic options of endometrial hyperplasia management. Current recommendations and prospective directions of treatment

Репродуктивная эндокринология, 2021
Endometrial hyperplasia (EH) is a pathological condition characterized by proliferation of the endometrial glands with an increase in the glands/stroma ratio compared to normal proliferative endometrium. EH is a precursor to the development of one of the
T.F. Tatarchuk, T.I. Kvasha, N.F. Zakharenko, N.V. Kosei, V.S. Solskyy, I.V. Shmulian   +5 more
doaj   +1 more source

The real experience with women's hysterectomy: A meta‐synthesis of qualitative research evidence

Nursing Open, Volume 10, Issue 2, Page 435-449, February 2023., 2023
Abstract Aim The aim of this meta‐synthesis was to identify and synthesize qualitative research evaluating the real feelings, inner needs and emotional experience of women undergoing hysterectomy. Design Meta‐synthesis. Methods The PubMed, Web of Science, Cochrane Library, CINAHL, Embase, Ovid Medline and Sino Med were systematically searched until ...
Na Li, Chen Shen, Rao Wang, Zhiping Chu
wiley   +1 more source

Effects of oral contraceptives on metabolic parameters in adult premenopausal women: a meta-analysis

Endocrine Connections, 2020
Objective: To estimate the effect of oral contraceptives (OC) containing di fferent progestins on parameters of lipid and carbohydrate metabolism through a systematic review and meta-analysis. Patients and methods: Premenopausal women aged 18 or older,
Lina S Silva-Bermudez, Freddy J K Toloza, Maria C Perez-Matos, Russell J de Souza, Laura Banfield, Andrea Vargas-Villanueva, Carlos O Mendivil   +6 more
doaj   +1 more source

Salivary and plasmatic levels of tumor necrosis factor‐alpha do not correlate with the clinicopathological profile in breast cancer patients

Precision Medical Sciences, Volume 11, Issue 4, Page 155-160, December 2022., 2022
Tumor necrosis factor (TNF) levels in saliva and plasma samples from patients diagnosed with breast cancer do not correlate with clinicopathological features that are indicative of disease prognosis. Abstract Herein, we evaluated the salivary and plasmatic levels of tumor necrosis factor‐alpha (TNF‐α) in women diagnosed with breast cancer (BC; n = 20 ...
Marcelo Marcos Opolski, Vitor Teixeira Maito, Aedra Carla Bufalo Kawassaki, Janaína Carla da Silva, Rodrigo Kern, Daniel Rech, Stefania Tagliari de Oliveira, Pâmela Lonardoni Micheletti, Carolina Panis, Sabrina Grassiolli   +9 more
wiley   +1 more source

Pharmaceutical-technological aspects of therapeutic systems for hormonal contraception [PDF]

Arhiv za farmaciju, 2016
The use of therapeutic systems for hormonal contraception (TSHC) represents an important alternative approach for prevention of unintended pregnancies in comparison to oral hormonal contraceptives, whereby the risk of gastrointestinal adverse effects ...
Đekić Ljiljana, Primorac Marija
doaj   +1 more source

Endometrial hyperplasia and progesterone resistance: a complex relationship

RUDN Journal of Medicine, 2023
The endometrium is one of the most dynamic tissues that constantly undergoes changes during the menstrual cycle in women of the reproductive period. All these processes take place mainly under the influence of steroid hormones that are produced in the ...
Mekan R. Orazov, Ludmila M. Mikhaleva, Irina A. Mullina   +2 more
doaj   +1 more source