Results 221 to 230 of about 270,741 (258)

Programmed cell death and the caspases

APMIS, 1999
Members of a family of cysteine proteases known as caspases orchestrate the intracellular biochemical events that enable animal cells to kill themselves by apoptosis. To counteract the apoptotic response to infection, some viruses have adapted and evolved proteins that specifically block caspases. More recently, it has been demonstrated that endogenous
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Programmed cell death in trypanosomatids

Parasitology Today, 1997
It has generally been assumed that apoptosis and other forms of programmed cell death evolved to regulate growth and development in multicellular organisms. However, recent work has shown that some parasitic protozoa have evolved a cell suicide pathway analogous to the process described as apoptosis in metazoa.
S C, Welburn, M A, Barcinski, G T, Williams   +2 more
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The machinery of programmed cell death

Pharmacology & Therapeutics, 2001
Apoptosis or programmed cell death is an essential physiological process that plays a critical role in development and tissue homeostasis. However, apoptosis is also involved in a wide range of pathological conditions. Apoptotic cells may be characterized by specific morphological and biochemical changes, including cell shrinkage, chromatin ...
K C, Zimmermann, C, Bonzon, D R, Green
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Programmed cell death in invertebrates

Current Opinion in Genetics & Development, 1996
Genetic studies of programmed cell death in Caenorhabditis elegans and Drosophila melanogaster have led to the identification of several invertebrate cell death genes. In C. elegans, ced-3 and ced-4 function to kill cells, whereas ced-9 protects cells from death.
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Erythrocyte programmed cell death

IUBMB Life, 2008
AbstractEryptosis, the suicidal death of erythrocytes, is characterised by cell shrinkage, membrane blebbing and cell membrane phospholipid scrambling with phosphatidylserine exposure at the cell surface. Phosphatidylserine‐exposing erythrocytes are recognised by macrophages, which engulf and degrade the affected cells.
Michael, Föller, Stephan M, Huber, Florian, Lang   +2 more
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Programmed cell death in osteoarthritis

Apoptosis
Osteoarthritis (OA) is a prevalent degenerative joint disease with complex and multifactorial etiology, primarily affecting elderly populations. Factors such as mechanical stress and aging contribute to cartilage degeneration and joint damage. OA manifests through extracellular matrix (ECM) degradation in chondrocytes, decreased chondrocyte viability ...
Haolin, Li, Ping, Chen, Weigang, Cheng, Zhimin, Zhang, Juanjuan, Yang, Hao, Zhang, Fangmei, Jin, Lili, Kan, Lei, Chen, Haidong, Wang   +9 more
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Programmed cell death in plants

Biochemistry (Moscow), 2012
The modern concepts of programmed cell death (PCD) in plants are reviewed as compared to PCD (apoptosis) in animals. Special attention is focused on considering the potential mechanisms of implementation of this fundamental biological process and its participants.
A S, Fomicheva, A I, Tuzhikov, R E, Beloshistov, S V, Trusova, R A, Galiullina, L V, Mochalova, N V, Chichkova, A B, Vartapetian   +7 more
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Programmed cell death and the proteasome

Apoptosis, 1998
A characteristic feature of apoptotic cell death is the activation of a cascade of cytoplasmic proteases that results in the cleavage of a limited number of target proteins. A central role in these proteolytic events has been assigned to members of the capase family.
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Programmed cell death in cell cultures

Plant Molecular Biology, 2000
In plants most instances of programmed cell death (PCD) occur in a number of related, or neighbouring, cells in specific tissues. However, recent research with plant cell cultures has demonstrated that PCD can be induced in single cells. The uniformity, accessibility and reduced complexity of cell cultures make them ideal research tools to investigate ...
P F, McCabe, C J, Leaver
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Serpins and Programmed Cell Death

1997
Cell death is a normal feature of animal development. Studies on a number of cell types, such as neurons that die during growth of young animal nervous systems and lymphocytes that die during receptor repertoire selection in adults, have shown that cells usually kill themselves by activating built in suicide mechanisms1. In mature organisms cell number
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