Results 171 to 180 of about 22,223,348 (210)

SLP2/PHB Aggregates in ALS Mouse Models and Patients: Implications Beyond <i>CHCHD10</i>-Associated Motor Neuron Disease. [PDF]

Int J Mol Sci
Genin EC, Lespinasse F, Mauri-Crouzet A, Dupuis L, Paquis-Flucklinger V.   +4 more
europepmc   +1 more source

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase.

Cell Rep
Elancheliyan P, Maruszczak KK, Serwa RA, Stephan T, Gulgec AS, Borrero-Landazabal MA, Ngati S, Gosk A, Jakobs S, Wasilewski M, Chacinska A.   +10 more
europepmc   +1 more source

Prohibitin 2: A key regulator of cell function.

Life Sciences, 2023
The PHB2 gene is located on chromosome 12p13 and encodes prohibitin 2, a highly conserved protein of 37 kDa. PHB2 is a dimer with antiparallel coils, possessing a unique negatively charged region crucial for its mitochondrial molecular chaperone ...
Bingjie Zhang, Wentao Li, Jiaying Cao, Yanhong Zhou, Xia Yuan   +4 more
semanticscholar   +3 more sources

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Sensitive electrochemical immunosensor to detect prohibitin 2, a potential blood cancer biomarker.

Talanta, 2021
Blood cancers are difficult to cure completely and frequently show a poor prognosis. Recently, prohibitin 2 (PHB2) has been shown to be a potential biomarker for blood cancers. Sandwich ELISA can be used as a reference method for quantitative analysis of PHB2; however, ELISA can be challenging for early diagnosis and continuous monitoring method due to
Young-Ran Yun, Seung Yeob Lee, B. Seo, Hojin Kim, M. Shin, Sung Yang   +5 more
semanticscholar   +3 more sources

Prohibitin 2: At a communications crossroads

IUBMB Life, 2015
AbstractProhibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators
Alberto Bavelloni, Manuela Piazzi, Irene Faenza   +2 more
exaly   +3 more sources

Minimal change nephrotic syndrome and prohibitin-2 gene polymorphism

Clinical and Experimental Nephrology, 2016
Patients with minimal change nephrotic syndrome (MCNS) often also have allergic diseases. Abnormalities of Th2-derived cytokines and T-cell functions contribute to development of these diseases. On the other hand, imbalances between reactive oxygen species (ROS) and antioxidants have been implicated in MCNS and progression of atopic dermatitis.
Keisuke, Sugimoto, Tomoki, Miyazawa, Kohei, Miyazaki, Hidehiko, Yanagida, Takuji, Enya, Hitomi, Nishi, Norihisa, Wada, Mitsuru, Okada, Tsukasa, Takemura   +8 more
openaire   +2 more sources

Prohibitin 2 is a Key Regulator of T Cell Proliferation and Effector Functions

bioRxiv
AbstractProhibitin 2 (PHB2) is a highly conserved protein with essential roles in cell homeostasis and survival across different cell types. Previous studies have shown that the deletion of PHB2 results in an arrest in proliferation due to impaired mitochondrial function regulated by the dynamin-like GTPase OPA1.
Johannes F. Vogt, Carsten Merkwirth, P. Adams-Quack, Elena Zurkowski, Thomas Michna, Assel Nurbekova, Ute Distler, H. Yurugi, S. Reissig, F. T. Wunderlich, K. Rajalingam, Stephan Tenzer, Axel Methner, Thomas Langer, A. Waisman, Nadine Hövelmeyer   +15 more
semanticscholar   +2 more sources

Unravelling the anti-apoptotic role of Plasmodium falciparum Prohibitin-2 (PfPhb2) in maintaining mitochondrial homeostasis.

Mitochondrion
The functional mitochondrion is vital for the propagation of the malaria parasite in the human host. Members of the SPFH protein family, Prohibitins (PHBs), are known to play crucial roles in maintaining mitochondrial homeostasis and cellular functions.
Shilpi Jain, M. Narwal, Md Omair Anwar, Neha Prakash, A. Mohmmed   +4 more
semanticscholar   +3 more sources

Prohibitin 2 Regulates Cell Proliferation and Mitochondrial Cristae Morphogenesis in Planarian Stem Cells

Stem Cell Reviews and Reports, 2014
Prohibitins are pleiotropic proteins, whose multiple roles are emerging as key elements in the regulation of cell survival and proliferation. Indeed, prohibitins interact with several intracellular proteins strategically involved in the regulation of cell cycle progression in response to extracellular growth signals.
ROSSI, LEONARDO, Lucia Bonuccelli, IACOPETTI, PAOLA, Monica Evangelista, GHEZZANI, CLAUDIO, Luigi Tana, SALVETTI, ALESSANDRA   +6 more
openaire   +3 more sources