Results 161 to 170 of about 24,430,487 (196)
Identification and characterization of prohibitin as a receptor protein mediating DENV-2 entry into insect cells [PDF]
Virology, 2010 Dengue is transmitted primarily by mosquitoes of the Aedes genus. Despite a number of studies, no insect dengue virus receptor protein has been clearly identified and characterized. Using a number of separation methodologies and virus overlay protein binding assays we identified a 35kDa protein that segregated with susceptibility to dengue serotype 2 ...
Duncan R Smith
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Prohibitin, an antiproliferative protein, is localized to mitochondria [PDF]
FEBS Letters, 1995 Prohibitin is a ubiquitously expressed protein with antiproliferative properties. When rat prohibitin tagged with a carboxy-terminal c-Myc epitope was expressed in baby hamster kidney cells the protein was targeted to mitochondria.
Elina Ikonen, Robert Parton
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Sensitive electrochemical immunosensor to detect prohibitin 2, a potential blood cancer biomarker
Talanta, 2022Blood cancers are difficult to cure completely and frequently show a poor prognosis. Recently, prohibitin 2 (PHB2) has been shown to be a potential biomarker for blood cancers. Sandwich ELISA can be used as a reference method for quantitative analysis of PHB2; however, ELISA can be challenging for early diagnosis and continuous monitoring method due to
Young-Ran Yun +5 more
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Minimal change nephrotic syndrome and prohibitin-2 gene polymorphism
Clinical and Experimental Nephrology, 2016Patients with minimal change nephrotic syndrome (MCNS) often also have allergic diseases. Abnormalities of Th2-derived cytokines and T-cell functions contribute to development of these diseases. On the other hand, imbalances between reactive oxygen species (ROS) and antioxidants have been implicated in MCNS and progression of atopic dermatitis.
Keisuke, Sugimoto +8 more
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Analysis of the effect of the mitochondrial prohibitin complex, a context-dependent modulator of longevity, on the C. elegans metabolome [PDF]
Biochimica Et Biophysica Acta - Bioenergetics, 2015 12 páginas; 5 figuras; 4 tablas; 4 figuras.-- This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging. Guest Editor: Aleksandra Trifunovic.-- Under a Creative Commons license.The mitochondrial prohibitin complex, composed of ...
Artur Bastos Lourenço +1 more
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Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus
Biochemical and Biophysical Research Communications, 2009Capsaicin is widely used as a food additive and as an analgesic agent. Besides its well-known role in nociception, which is mediated by vanilloid receptor 1 specifically expressed in dorsal root ganglion neurons, capsaicin has also been considered as a potential anticancer agent, as it inhibits cell proliferation and induces apoptosis in various types ...
Chikanori Kuramori +10 more
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Association of prohibitin-1 and 2 with oxidative stress in rats with renal interstitial fibrosis
Molecular Biology Reports, 2014Prohibitins PHB1 and PHB2 are evolutionary conserved and pleiotropic proteins, which have been shown to be important factors in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding. Recently, we demonstrated that down-regulation promoted renal interstitial fibrosis (RIF) in
Tian-Biao, Zhou +4 more
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Fish & Shellfish Immunology, 2015
The highly conserved protein prohibitin 2 (PHB2) has been implicated as a cell-surface receptor in the regulation of proliferation, apoptosis, transcription, and mitochondrial protein folding. In the present study, we identified a Lampetra morii homologue of PHB2, Lm-PHB2, showing greater than 61.8% sequence identity with its homologues.
Tiesong Li +3 more
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The highly conserved protein prohibitin 2 (PHB2) has been implicated as a cell-surface receptor in the regulation of proliferation, apoptosis, transcription, and mitochondrial protein folding. In the present study, we identified a Lampetra morii homologue of PHB2, Lm-PHB2, showing greater than 61.8% sequence identity with its homologues.
Tiesong Li +3 more
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Isolation of mutations synthetic-lethal to prohibitin 2 null mutants of Saccharomyces cerevisiae
Antonie van Leeuwenhoek, 2006Prohibitins are ubiquitous, abundant proteins found in a wide range of organisms and that have a high degree of sequence conservation. In yeast it has previously been demonstrated that prohibitin proteins form a complex and are involved in maintaining the morphological and functional integrity of mitochondria. We have used a colony-sectoring assay as a
Feng, Liu, Derek J, Jamieson
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Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase
Biochemical and Biophysical Research Communications, 2018Previous studies show that gamma-glutamylcyclotransferase (GGCT) is expressed at high levels in various cancer tissues and that its knockdown inhibits MCF7 cancer cell growth via upregulation of p21WAF1/CIP1 (p21). However, the detailed underlying mechanism is unclear.
Keiko Taniguchi +8 more
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