Results 181 to 190 of about 22,223,348 (210)

Isolation of mutations synthetic-lethal to prohibitin 2 null mutants of Saccharomyces cerevisiae

Antonie van Leeuwenhoek, 2006
Prohibitins are ubiquitous, abundant proteins found in a wide range of organisms and that have a high degree of sequence conservation. In yeast it has previously been demonstrated that prohibitin proteins form a complex and are involved in maintaining the morphological and functional integrity of mitochondria. We have used a colony-sectoring assay as a
Feng, Liu, Derek J, Jamieson
openaire   +2 more sources

Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation.

AJP - Renal Physiology, 2019
Accumulating evidence demonstrates that mitochondrial dysfunction and inflammasome activation play a critical role in the pathogenesis of renal tubular injury through the production of reactive oxygen species and cytokines. Prohibitin 2 (PHB2) is a newly
Yao Xu, Jingjing Wang, Wangjie Xu, F. Ding, W. Ding   +4 more
semanticscholar   +1 more source

Prohibitin-1 and -2 have diverse cell-autonomous effects on inflammatory signaling

The Journal of Immunology, 2018
Abstract Prohibitins (PHB1 and PHB2) are proteins that assemble in hetero-oligomeric complexes within the mitochondrial inner membrane and in the plasma membrane lipid rafts where they are at the nexus of metabolic and pro-survival decisions including inflammation.
Christine E Psaltis, Jim Aloor, Sky W Reece, Brita Kilburg-Basnyat, Jacques Robidoux, Michael Fessler, Ethan Anderson, Kymberly Gowdy   +7 more
openaire   +1 more source

Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

Biochemical and Biophysical Research Communications, 2009
Capsaicin is widely used as a food additive and as an analgesic agent. Besides its well-known role in nociception, which is mediated by vanilloid receptor 1 specifically expressed in dorsal root ganglion neurons, capsaicin has also been considered as a potential anticancer agent, as it inhibits cell proliferation and induces apoptosis in various types ...
Chikanori Kuramori, Motoki Azuma, Kanako Kume, Yuki Kaneko, Atsushi Inoue, Yuki Yamaguchi, Yasuaki Kabe, Takamitsu Hosoya, Masahiro Kizaki, Makoto Suematsu, Hiroshi Handa   +10 more
openaire   +2 more sources

Differential binding of prohibitin-2 to estrogen receptor α and to drug-resistant ERα mutants

Biochemical and Biophysical Research Communications, 2015
Endocrine resistance is one of the most challenging problems in estrogen receptor alpha (ERα)-positive breast cancer. The transcriptional activity of ERα is controlled by several coregulators, including prohibitin-2 (PHB2). Because of its ability to repress the transcriptional activity of activated ERα, PHB2 is a promising antiproliferative agent.
Takeru Chigira, Satoru Nagatoishi, Kouhei Tsumoto   +2 more
openaire   +2 more sources

Identification and characterisation of the anti-oxidative stress properties of the lamprey prohibitin 2 gene

Fish & Shellfish Immunology, 2015
The highly conserved protein prohibitin 2 (PHB2) has been implicated as a cell-surface receptor in the regulation of proliferation, apoptosis, transcription, and mitochondrial protein folding. In the present study, we identified a Lampetra morii homologue of PHB2, Lm-PHB2, showing greater than 61.8% sequence identity with its homologues.
Tiesong Li, Ying Wang, Yang Gao, Qingwei Li   +3 more
openaire   +2 more sources

Decreasing expression of Prohibitin-2 lowers the oncogenicity of renal cell carcinoma cells by suppressing eIF4E-mediated oncogene translation via MNK inhibition.

Toxicology and Applied Pharmacology, 2023
Jie Yang, Gang Li, Yue’e Huang, Y. Liu
semanticscholar   +1 more source

The Action and Mechanism of Action Inner Mitochondrial Membrane Protein Prohibitin 2 in Ischaemic Wound Repair: An Animal Study

Journal of Biological Regulators and Homeostatic Agents, 2023

semanticscholar   +1 more source

Lamprey prohibitin 2 inhibits non-small cell lung carcinoma cell proliferation by down-regulating the expression and phosphorylation levels of cell cycle-associated proteins.

Fish and Shellfish Immunology, 2023
Xue Zhang, Jianzhu Zhao, Qing Li, Di Qin, Wenwei Li, Xinyu Wang, Mengfei Bi, Qingwei Li, Tiesong Li   +8 more
semanticscholar   +1 more source

Mitochondrial function and morphology in prohibitin 2 deleted ß-cells and hepatocytes

2017
Ce projet se concentre sur une famille de protéines mitochondriales: les prohibitines. Les prohibitines (Phb1 et Phb2) sont situées sur la membrane interne des mitochondries et participent à diverses fonctions cellulaires. La délétion in vitro de Phb2 provoque une augmentation du clivage de la machinerie de fusion mitochondriale GTPase OPA1, conduisant
openaire   +2 more sources