Results 161 to 170 of about 1,728 (183)
Prohibitins Regulate Membrane Protein Degradation by the m -AAA Protease in Mitochondria
Molecular and Cellular Biology, 1999 Prohibitins comprise a protein family in eukaryotic cells with potential roles in senescence and tumor suppression. Phb1p and Phb2p, members of the prohibitin family in Saccharomyces cerevisiae, have been implicated in the regulation of the replicative ...
Walter Neupert, Thomas Langer
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Prohibitin 2: At a communications crossroads
IUBMB Life, 2015AbstractProhibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators
Bavelloni A +4 more
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Molecular modeling of prohibitin domains
Proteins: Structure, Function, and Bioinformatics, 2007AbstractProhibitins comprise a family of highly conserved ubiquitous eukaryotic proteins that mainly localize to the mitochondria. They have been implicated in important cellular processes such as cellular signaling and transcriptional control, apoptosis, cellular senescence, and mitochondrial biogenesis.
Winter, Anja +2 more
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Prohibitin in Adipose and Immune Functions
Trends in Endocrinology & Metabolism, 2016Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence.
Sudharsana R, Ande +3 more
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Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins
EMBO Journal, 2000 Prohibitins are ubiquitous, abundant and evolutionarily strongly conserved proteins that play a role in important cellular processes. Using blue native electrophoresis we have demonstrated that human prohibitin and Bap37 together form a large complex in ...
Leo G J Nijtmans +2 more
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Identification of prohibitin as an antigen in Behcet’s disease
Biochemical and Biophysical Research Communications, 2014This study is intended to screen potential antigen for Behcet's disease (BD) by using human microvascular endothelial cells (HUVEC).Following cell-based indirect immunofluorescence assay with sera from BD patients, proteins extracted from HUVEC were separated and detected by Western blotting.
Yiping, Xun +6 more
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Prohibitin plays a role in the functional plasticity of macrophages
Molecular Immunology, 2022Immunometabolism plays a crucial role in the activation and functional plasticity of immune cells, which in large determines a variety of health and disease states. Factors that integrate immunometabolism in immune cell signaling and functions are beginning to be identified.
Yang Xin Zi, Xu +5 more
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Prohibitin: a potential target for new therapeutics
Trends in Molecular Medicine, 2005Prohibitin (PHB) is localized to the mitochondria where it might have a role in the maintenance of mitochondrial function and protection against senescence. There is considerable controversy concerning the function of nuclear-localized PHB. PHB has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle ...
Suresh, Mishra +3 more
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Prohibitin is involved in mitochondrial biogenesis in plants
The Plant Journal, 2006SummaryProhibitin, which consists of two subunits PHB1 and PHB2, plays a role in cell‐cycle progression, senescence, apoptosis, and maintenance of mitochondrial function in mammals and yeast. In this study, we examined the role of prohibitins in plants by using virus‐induced gene silencing (VIGS) of two prohibitin subunit genes of Nicotiana benthamiana,
Chang Sook, Ahn +4 more
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Prohibitin Signaling at the Kidney Filtration Barrier
2017The kidney filtration barrier consists of three well-defined anatomic layers comprising a fenestrated endothelium, the glomerular basement membrane (GBM) and glomerular epithelial cells, the podocytes. Podocytes are post-mitotic and terminally differentiated cells with primary and secondary processes.
Christina, Ising, Paul T, Brinkkoetter
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