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Prohibitin: a potential target for new therapeutics
Trends in Molecular Medicine, 2005Prohibitin (PHB) is localized to the mitochondria where it might have a role in the maintenance of mitochondrial function and protection against senescence. There is considerable controversy concerning the function of nuclear-localized PHB. PHB has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle ...
Suresh, Mishra +3 more
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Prohibitin is involved in mitochondrial biogenesis in plants
The Plant Journal, 2006SummaryProhibitin, which consists of two subunits PHB1 and PHB2, plays a role in cell‐cycle progression, senescence, apoptosis, and maintenance of mitochondrial function in mammals and yeast. In this study, we examined the role of prohibitins in plants by using virus‐induced gene silencing (VIGS) of two prohibitin subunit genes of Nicotiana benthamiana,
Chang Sook, Ahn +4 more
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Prohibitin Signaling at the Kidney Filtration Barrier
2017The kidney filtration barrier consists of three well-defined anatomic layers comprising a fenestrated endothelium, the glomerular basement membrane (GBM) and glomerular epithelial cells, the podocytes. Podocytes are post-mitotic and terminally differentiated cells with primary and secondary processes.
Christina, Ising, Paul T, Brinkkoetter
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Emerging roles of prohibitins in cancer: an update
Cancer Gene TherapyThe prohibitin (PHB) family, including PHB1 and its homolog PHB2, is ubiquitously located in different cellular compartments and plays roles in fundamental cellular processes such as proliferation, differentiation, and apoptosis. Accumulating evidence has indicated that this family contributes to the development of numerous diseases in particular ...
Yunliang Gao, Yuanyuan Tang
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The Effect of Prohibitins on Mitochondrial Function during Octopus tankahkeei Spermiogenesis
International Journal of Molecular Sciences, 2023Junquan Zhu +2 more
exaly
Expression of prohibitin, an antiproliferative protein
Experimental Gerontology, 1992J K, McClung +6 more
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