Results 171 to 180 of about 2,450 (184)
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Prohibitin and the senescent phenotype
Experimental Gerontology, 1996Prohibitin is an evolutionarily conserved gene that has antiproliferative activity, is ubiquitously expressed, and appears to be essential for cell survival. The gene codes for a 30 kD, post-synthetically modified protein located primarily in the mitochondria.
R T, Dell'Orco +3 more
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Prohibitin 2: At a communications crossroads
IUBMB Life, 2015AbstractProhibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators
Bavelloni A +4 more
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Prohibitin in Adipose and Immune Functions
Trends in Endocrinology & Metabolism, 2016Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence.
Sudharsana R, Ande +3 more
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Prohibitin: a potential target for new therapeutics
Trends in Molecular Medicine, 2005Prohibitin (PHB) is localized to the mitochondria where it might have a role in the maintenance of mitochondrial function and protection against senescence. There is considerable controversy concerning the function of nuclear-localized PHB. PHB has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle ...
Suresh, Mishra +3 more
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Prohibitin Signaling at the Kidney Filtration Barrier
2017The kidney filtration barrier consists of three well-defined anatomic layers comprising a fenestrated endothelium, the glomerular basement membrane (GBM) and glomerular epithelial cells, the podocytes. Podocytes are post-mitotic and terminally differentiated cells with primary and secondary processes.
Christina, Ising, Paul T, Brinkkoetter
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Prohibitin is involved in mitochondrial biogenesis in plants
The Plant Journal, 2006SummaryProhibitin, which consists of two subunits PHB1 and PHB2, plays a role in cell‐cycle progression, senescence, apoptosis, and maintenance of mitochondrial function in mammals and yeast. In this study, we examined the role of prohibitins in plants by using virus‐induced gene silencing (VIGS) of two prohibitin subunit genes of Nicotiana benthamiana,
Chang Sook, Ahn +4 more
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Prohibitin has an important role in adipocyte differentiation
International Journal of Obesity, 2011To investigate whether prohibitin (PHB) is a target gene in adipocyte differentiation and modulates insulin-induced adipocyte differentiation.3T3-L1 preadipocyte overexpressing wild-type PHB and PHB mutant (lacking tyrosine-114 phosphorylation site) with or without insulin.The treatment of 3T3-L1 fibroblasts with insulin or peroxisome proliferator ...
S R, Ande, Z, Xu, Y, Gu, S, Mishra
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Prohibitin: Mitochondrial Tumor Suppressor Protein
1998The prohibitin story begins with the development of an assay for the detection of mRNAs that could inhibit the initiation of DNA synthesis.1’2 Messenger RNAs were tested by microinjecting them into individual human diploid fibroblasts that had been growth-arrested by serum restriction.
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Expression of prohibitin, an antiproliferative protein
Experimental Gerontology, 1992J K, McClung +6 more
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