Results 141 to 150 of about 88,083 (193)

Case Report: Hyperprolinemia type II in a child with autism spectrum disorder and ALDH4A1 gene variant in a consanguineous family. [PDF]

Front Pediatr
AlQurashi FO, Alawam BS, Alhaddad B, Alrebh ZA.   +3 more
europepmc   +1 more source

Metabolic reprogramming in cancer: dysregulation of glucose, lipid, and amino acid pathways and therapeutic opportunities. [PDF]

Mol Biomed
Yu M, Yang D, Chen X, Yang Y, Zhang B, Jiang X, Xing L, Yang Y, Sun Y, Li N.   +9 more
europepmc   +1 more source

Red Blood Cell Metabolomic Signatures in β-Thalassemia Heterozygotes With Elevated HbA_1c: Implications for Biomarkers and Personalized Medicine. [PDF]

J Diabetes Sci Technol
Nuinoon M, Jeenduang N, Piwkham D, Khongsathan W, Sarakul O.   +4 more
europepmc   +1 more source

Structural evolution of the whole mitochondrial genome and phylogenetic inference in snakes (Squamata: Serpentes), including the undescribed mitogenome of the Brazilian endemic and critically endangered pitviper Bothrops insularis. [PDF]

Genet Mol Biol
Salles-Oliveira I, Patané JSL, Nishiyama-Júnior MY, Silva MJJ.   +3 more
europepmc   +1 more source

Effect of Nickel Stress on Nitrogen Metabolism in Cucumber Plants. [PDF]

Int J Mol Sci
Gajewska E, Witusińska A.
europepmc   +1 more source

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Microbial Proline Racemase–Proline Dehydrogenase Cascade for Efficient Production of d-proline and N-boc-5-hydroxy-l-proline from l-proline

Applied Biochemistry and Biotechnology, 2022
D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang, Shiwen Xia, Hui Lin, Jiao Liu, Wenxin Huang   +4 more
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Proline promotes proliferation and drug resistance of multiple myeloma by downregulation of proline dehydrogenase

British Journal of Haematology, 2023
SummaryAmino acids in the bone marrow microenvironment (BMME) are a critical factor for multiple myeloma (MM) progression. Here, we have determined that proline is elevated in BMME of MM patients and links to poor prognosis in MM. Moreover, exogenous proline regulates MM cell proliferation and drug resistance.
Jingyu Zhang, Fangming Shi, Xing Liu, Xuan Wu, Cong Hu, Jiaojiao Guo, Qin Yang, Jiliang Xia, Yanjuan He, Gang An, Lugui Qiu, Xiangling Feng, Wen Zhou   +12 more
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Mechanism-based inhibition of proline dehydrogenase by proline analogues

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993
The inactivation of proline dehydrogenase by several L-Pro analogues was investigated with the aim to block the essential metabolic pathway of tsetse flies allowing the degradation of L-Pro to L-Glu. In vitro studies on rat liver mitochondria showed that only 4-methylene-L-proline was able to inactivate proline dehydrogenase.
D, Tritsch, H, Mawlawi, J F, Biellmann
openaire   +2 more sources