Results 211 to 220 of about 88,584 (246)

Proline dehydrogenase-entrapped mesoporous magnetic silica nanomaterial for electrochemical biosensing of L-proline in biological fluids

Enzyme and Microbial Technology, 2017
In this work, physical adsorption was used for immobilization of proline dehydrogenase onto a magnetic mesoporous silica nanomaterial. The immobilization and electrocatalytical activity of proline dehydrogenase entrapped in a magnetic mesoporous silica nanomaterial was studied using cyclic voltammetry, differential pulse voltammetry, and square wave ...
Mohammad, Hasanzadeh, Arezoo Saadati, Nahar, Soodabeh, Hassanpour, Nasrin, Shadjou, Ahad, Mokhtarzadeh, Jalal, Mohammadi   +5 more
openaire   +4 more sources

The gene encoding proline dehydrogenase modulates sensorimotor gating in mice

Nature Genetics, 1999
Hemizygous cryptic deletions of the q11 band of human chromosome 22 have been associated with a number of psychiatric and behavioural phenotypes, including schizophrenia. Here we report the isolation and characterization of PRODH, a human homologue of Drosophila melanogaster sluggish-A (slgA), which encodes proline dehydrogenase responsible for the ...
J A, Gogos, M, Santha, Z, Takacs, K D, Beck, V, Luine, L R, Lucas, J V, Nadler, M, Karayiorgou   +7 more
openaire   +4 more sources

Responsive modes of Medicago sativa proline dehydrogenase genes during salt stress and recovery dictate free proline accumulation

Planta, 2005
Free proline accumulation is an innate response of many plants to osmotic stress. To characterize transcriptional regulation of the key proline cycle enzymes in alfalfa (Medicago sativa), two proline dehydrogenase (MsPDH) genes and a partial sequence of Delta (1) -pyrroline-5-carboxylate dehydrogenase (MsP5CDH) gene were identified and cloned.
Gadi, Miller, Hanan, Stein, Arik, Honig, Yoram, Kapulnik, Aviah, Zilberstein   +4 more
openaire   +4 more sources

Microbial Proline Racemase–Proline Dehydrogenase Cascade for Efficient Production of d-proline and N-boc-5-hydroxy-l-proline from l-proline

Applied Biochemistry and Biotechnology, 2022
D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang, Shiwen Xia, Hui Lin, Jiao Liu, Wenxin Huang   +4 more
openaire   +2 more sources

Proline promotes proliferation and drug resistance of multiple myeloma by downregulation of proline dehydrogenase

British Journal of Haematology, 2023
SummaryAmino acids in the bone marrow microenvironment (BMME) are a critical factor for multiple myeloma (MM) progression. Here, we have determined that proline is elevated in BMME of MM patients and links to poor prognosis in MM. Moreover, exogenous proline regulates MM cell proliferation and drug resistance.
Jingyu Zhang, Fangming Shi, Xing Liu, Xuan Wu, Cong Hu, Jiaojiao Guo, Qin Yang, Jiliang Xia, Yanjuan He, Gang An, Lugui Qiu, Xiangling Feng, Wen Zhou   +12 more
openaire   +2 more sources

Mechanism-based inhibition of proline dehydrogenase by proline analogues

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993
The inactivation of proline dehydrogenase by several L-Pro analogues was investigated with the aim to block the essential metabolic pathway of tsetse flies allowing the degradation of L-Pro to L-Glu. In vitro studies on rat liver mitochondria showed that only 4-methylene-L-proline was able to inactivate proline dehydrogenase.
D, Tritsch, H, Mawlawi, J F, Biellmann
openaire   +2 more sources

Allohydroxy-d-proline dehydrogenase

Archives of Microbiology, 1977
Growth of Pseudomonas aeruginosa PA01 on isomers of hydroxyproline induced the synthesis of an allohydroxy-D-proline dehydrogenase. The enzyme resembled the D-alanine dehydrogenase of this organism in its association with the particulate fraction and its linkage to oxygen through a cytochrome-containing respiratory chain, but differed from this and ...
A J, Bater, W A, Venables, S, Thomas
openaire   +2 more sources

Prolidase‐proline dehydrogenase/proline oxidase‐collagen biosynthesis axis as a potential interface of apoptosis/autophagy

BioFactors, 2016
AbstractProlidase is a cytosolic imidodipeptidase that specifically splits imidodipeptides with C‐terminal proline or hydroxyproline. The enzyme plays an important role in the recycling of proline from imidodipeptides for resynthesis of collagen and other proline‐containing proteins.
Ilona, Zareba, Jerzy, Palka
openaire   +2 more sources

A l-proline/O2 biofuel cell using l-proline dehydrogenase (LPDH) from Aeropyrum pernix

Molecular Biology Reports, 2018
To utilize amino acids from food waste as an energy source, L-proline/O2 biofuel cell was constructed using a stable enzyme from hyperthermophilic archaeon for long-term operation. On the anode, the electrocatalytic oxidation of L-proline by L-proline dehydrogenase from Aeropyrum pernix was observed in the presence of ferrocenecarboxylic acid as ...
Aina Tonooka, Tomohiro Komatsu, Shino Tanaka, Hiroaki Sakamoto, Takenori Satomura, Shin-ichiro Suye   +5 more
openaire   +2 more sources

Proline Dehydrogenase — A New Enzyme for Pollen

Biochemie und Physiologie der Pflanzen, 1976
Summary Using quantitative biochemical procedures, the distribution of proline dehydrogenase in pollengrains and pollen tubes of Crotalaria juncea L. is demonstrated for the first time. Increased accumulation of proline in the dormant pollen and its subsequent decrease in the germinating phase along with the increased activity of proline ...
C.P. Malik, M.B. Singh, Arvind Kapur
openaire   +1 more source