Capturing Transitional Pluripotency through Proline Metabolism [PDF]
Cells, 2022 In this paper, we summarize the current knowledge of the role of proline metabolism in the control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism shifts mouse ESCs toward a stable naïve-to-primed intermediate state of ...
Gabriella Minchiotti +4 more
doaj +4 more sources
Proline Metabolism in Tumor Growth and Metastatic Progression [PDF]
Frontiers in Oncology, 2020 Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.
Cristina D'Aniello +3 more
doaj +6 more sources
Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism [PDF]
Cell Death Discovery, 2023 The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether and how cells adapt their metabolic activity to ...
Jiahao He +3 more
doaj +2 more sources
Arbuscular mycorrhizal fungi enhanced rice proline metabolism under low temperature with nitric oxide involvement [PDF]
Frontiers in Plant Science, 2022 Arbuscular mycorrhizal fungi (AMF) are known to improve plant stress tolerance by regulating proline accumulation, and nitric oxide (NO) plays an important signaling role in proline metabolism.
Zhilei Liu +9 more
doaj +2 more sources
Proline metabolism is essential for alkaline adaptation of Nile tilapia (Oreochromis niloticus) [PDF]
Journal of Animal Science and BiotechnologyBackground Saline-alkaline water aquaculture has become a key way to mitigate the reduction of freshwater aquaculture space and meet the increasing global demand for aquatic products. To enhance the comprehensive utilization capability of saline-alkaline
Minxu Wang +6 more
doaj +2 more sources
Proline Metabolism in Neurological and Psychiatric Disorders. [PDF]
Mol Cells, 2022 Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric ...
Yao Y, Han W.
europepmc +3 more sources
Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress [PDF]
Cell Death and Disease, 2023 Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui +18 more
doaj +2 more sources
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells. [PDF]
PLoS ONE, 2022 Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There are three
Saif Sattar Alaqbi +17 more
doaj +2 more sources
Proline dehydrogenase, a rate-limiting catabolic enzyme, affecting the growth and pathogenicity of Toxoplasma gondii tachyzoites by regulating the proline metabolism and mitochondrial function of the parasite [PDF]
Parasites & VectorsBackground The pathogenicity of Toxoplasma gondii is closely associated with its intracellular lytic cycle in host cells. Currently, the mechanisms by which T. gondii completes the lytic cycle remain unclear.
Xiao-Ling Geng +9 more
doaj +2 more sources
Arbuscular Mycorrhizae Mitigate Aluminum Toxicity and Regulate Proline Metabolism in Plants Grown in Acidic Soil [PDF]
Journal of Fungi, 2021 Arbuscular mycorrhizal fungi (AMF) can promote plant growth and induce stress tolerance. Proline is reported to accumulate in mycorrhizal plants under stressful conditions, such as aluminum (Al) stress.
Modhi O. Alotaibi +6 more
doaj +2 more sources