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Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth
Cell Stress, 2020 Proline metabolism is critical for cellular response to microenvironmental stress in living organisms across different kingdoms, ranging from bacteria, plants to animals. In bacteria and plants, proline is known to accrue in response to osmotic and other
Ling Guo, Chuanyue Wu
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Proline Metabolism and Microenvironmental Stress [PDF]
Annual Review of Nutrition, 2010 Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic signaling. Collagen in extracellular matrix, connective tissue, and bone is an abundant reservoir for proline.
James M, Phang, Wei, Liu, Olga, Zabirnyk
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Substrate channeling in proline metabolism [PDF]
Frontiers in Bioscience, 2012 Proline metabolism is an important pathway that has relevance in several cellular functions such as redox balance, apoptosis, and cell survival. Results from different groups have indicated that substrate channeling of proline metabolic intermediates may be a critical mechanism.
Arentson, Benjamin W +2 more
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Inborn Errors of Proline Metabolism [PDF]
The Journal of Nutrition, 2008 l-Proline concentration is primarily related to the balance of enzymatic activities of proline dehydrogenase [proline oxidase (POX)] and Delta-1-pyrroline-5-carboxylate (P5C) reductase. As a result, P5C plays a pivotal role in maintaining the concentration of proline in body fluids and inborn errors of P5C metabolism lead to disturbance of proline ...
Hiroshi, Mitsubuchi +3 more
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Frontiers in Plant Science, 2020 Understanding the regulation of proline metabolism necessitates the suppression of two Δ1-pyrroline-5-carboxylate synthetase enzyme (P5CS) genes performed in switchgrass (Panicum virgatum L.).
Cong Guan +8 more
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Connecting proline metabolism and signaling pathways in plant senescence
Frontiers in Plant Science, 2015 The amino acid proline has a unique biological role in stress adaptation. Proline metabolism is manipulated under stress by multiple and complex regulatory pathways and can profoundly influence cell death and survival in microorganisms, plants, and ...
Lu eZhang, Donald eBecker
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Frontiers in Bioscience, 2012 Proline plays a special role in cancer metabolism. Proline oxidase (POX), a.k.a. proline dehydrogenase (PRODH), is among a few genes induced rapidly and robustly by P53, the tumor suppressor. Ectopic expression of POX under control of tet-off promoter initiated mitochondrial apoptosis. The mechanism activated by POX is mediated by its production of ROS.
James M, Phang, Wei, Liu
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Evaluation of P5CS and ProDH activity in Paulownia tomentosa (Steud.) as an indicator of oxidative changes induced by drought stress [PDF]
PeerJThe aim of the study was to investigate changes in proline metabolism in seedlings of tree species during drought stress. One month old Paulownia tomentosa seedlings were exposed to moisture conditions at various levels (irrigation at 100, 75, 50 and 25%
Joanna Kijowska-Oberc +3 more
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Proline: a key player in plant abiotic stress tolerance
Biologia Plantarum, 2015 Dramatic accumulation of proline is a common physiological response in plants exposed to various abiotic stresses. Accumulation of proline could be due to de novo synthesis, decreased degradation, lower utilization, or hydrolysis of proteins.
G. Kaur, B. Asthir
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Longevity Regulation by Proline Oxidation in Yeast
Microorganisms, 2021 Proline is a pivotal and multifunctional amino acid that is used not only as a nitrogen source but also as a stress protectant and energy source. Therefore, proline metabolism is known to be important in maintaining cellular homeostasis.
Akira Nishimura +5 more
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