Results 31 to 40 of about 101,283 (248)

Proline-dependent regulation of collagen metabolism [PDF]

Cellular and Molecular Life Sciences, 2019
AbstractThis review is focused on recent data on the role of proline (Pro) in collagen biosynthesis and cellular metabolism. It seems obvious that one of the main substrates for collagen biosynthesis Pro is required to form collagen molecule. The question raised in this review is whether the Pro for collagen biosynthesis is synthesized “de novo”, comes
Karna, Ewa, Szoka, Lukasz, Huynh, Thi Yen Ly, Palka, Jerzy A.   +3 more
openaire   +2 more sources

Proline modulates the Trypanosoma cruzi resistance to reactive oxygen species and drugs through a novel D, L-proline transporter. [PDF]

PLoS ONE, 2014
Trypanosoma cruzi, the etiological agent of Chagas' disease, has a metabolism largely based on the consumption of glucose and proline. This amino acid is essential for host cells infection and intracellular differentiation.
Melisa Sayé, Mariana R Miranda, Fabio di Girolamo, María de los Milagros Cámara, Claudio A Pereira   +4 more
doaj   +1 more source

Intestinal proline is a potential anti-allergy factor for allergy diagnosis and therapy

Frontiers in Nutrition, 2022
Allergy has become a public health problem worldwide, but effective diagnostic and therapeutic approaches are limited currently. Amino acids are essential macronutrients that potentially participated in the allergy process. This work aimed to investigate
Jinya Ma, Chong Wang, Fangting Wang, Yong Zhang, Yinghua Liu, Jiachao Zhang, Zhongshan Gao, Yi Zhang, Hujun Xie, Yanbo Wang, Linglin Fu   +10 more
doaj   +1 more source

OsProDH Negatively Regulates Thermotolerance in Rice by Modulating Proline Metabolism and Reactive Oxygen Species Scavenging

Rice, 2020
Background Global warming threatens rice growth and reduces yields. Proline plays important roles in plant abiotic stress tolerance. Previous research demonstrated that engineering proline metabolism-related genes can enhance tolerance to freezing and ...
Mingxin Guo, Xiaotian Zhang, Jiajia Liu, Linlin Hou, Hanxiao Liu, Xusheng Zhao   +5 more
doaj   +1 more source

The proline regulatory axis and cancer

Frontiers in Oncology, 2012
Studies in metabolism and cancer have characterized changes in core pathways involving glucose and glutamine, emphasizing the provision of substrates for building cell mass.
James Ming Phang
doaj   +1 more source

Melatonin treatment alleviates chilling injury in mango fruit ‘Keitt’ by modulating proline metabolism under chilling stress

Journal of Integrative Agriculture, 2023
Mangoes often suffer from low temperature-induced chilling injury (CI) during postharvest cold storage. Therefore, advanced techniques are crucial and in high demand to solve the chilling stress of mango fruit for a higher value.
Mariama KEBBEH, Jing-xian DONG, Chen HUAN, Yan LIU, Xiao-lin ZHENG   +4 more
doaj   +1 more source

Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae

Microbial Cell, 2019
In many plants and microorganisms, intracellular proline has a protective role against various stresses, including heat-shock, oxidation and osmolarity. Environmental stresses induce cellular senescence in a variety of eukaryotes.
Yukio Mukai, Yuka Kamei, Xu Liu, Shan Jiang, Yukiko Sugimoto, Noreen Suliani binti Mat Nanyan, Daisuke Watanabe, Hiroshi Takagi   +7 more
doaj   +1 more source

Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy [PDF]

Amino Acids, 2021
AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Jerzy Palka, Ilona Oscilowska, Lukasz Szoka   +2 more
openaire   +2 more sources

PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer

Pharmaceuticals, 2021
Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Magdalena Misiura, Ilona Ościłowska, Katarzyna Bielawska, Jerzy Pałka, Wojciech Miltyk   +4 more
doaj   +1 more source

Microbiota alterations in proline metabolism impact depression

Cell Metabolism, 2022
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors.
Mayneris-Perxachs, Jordi, Castells-Nobau, Anna, Arnoriaga-Rodríguez, María, Martin, Miquel, de la Vega-Correa, Lisset, Zapata, Cristina, Burokas, Aurelijus, Blasco, Gerard, Coll, Clàudia, Escrichs, Anira, Biarnés, Carles, Moreno-Navarrete, José María, Puig, Josep, Garre-Olmo, Josep, Ramos, Rafel, Pedraza, Salvador, Brugada, Ramón, Carles Vilanova, Joan, Serena, Joaquín, Gich, Jordi, Ramió-Torrentà, Lluís, Pérez-Brocal, Vicente, Moya, Andrés, Pamplona, Reinald, Sol, Joaquim, Jové, Mariona, Ricart, Wifredo, Portero-Otin, Manuel, Deco, Gustavo, Maldonado, Rafael, Fernández-Real, José Manuel   +30 more
openaire   +8 more sources