Results 11 to 20 of about 12,746 (209)

Stage-Specific Expression and Subcellular Localization of Calcineurin in Infective Forms of Leishmania amazonensis [PDF]

Pathogens
Calcineurin (CaN), a Ca2+-dependent phosphatase, plays key roles in eukaryotic cell signaling. We investigated whether Leishmania amazonensis’ two infective forms—promastigotes and amastigotes—exhibit differences in CaN expression, localization, and ...
Deborah Brandt-Almeida, Ismael Pretto Sauter, Mario Costa Cruz, Cristian Cortez, Patricio Reyes Orrego, Mauro Cortez   +5 more
doaj   +2 more sources

Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum [PDF]

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres‐Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, Diógenes Aparício Garcia Cortez, Benedito Prado Dias Filho   +8 more
wiley   +2 more sources

In Vitro Assessment of the Combined Activity of Amphotericin B and Cu2+-1,10-Phenanthroline-5,6-dione Coordination Compound Against Leishmania amazonensis Promastigotes [PDF]

Trop Med Infect Dis
Simone Santiago Carvalho de Oliveira, Débora Duarte Batista, Michael Devereux, Malachy McCann, Camilo Fernandes, André Luis Souza dos Santos, Marta H. Branquinha   +6 more
openalex   +2 more sources

Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells

Molecules, 2020
A stronger Th1 (cellular) immune response in canine leishmaniosis (CanL) leads to a better prognosis. Dietary nucleotides plus AHCC® have shown beneficial effects in dogs with clinical leishmaniosis and in clinically healthy Leishmania-infected dogs. The
María Auxiliadora Dea-Ayuela, Sergi Segarra, Dolores R. Serrano, Francisco Bolás-Fernández   +3 more
doaj   +1 more source

Design, Synthesis, and Repurposing of Rosmarinic Acid-β-Amino-α-Ketoamide Hybrids as Antileishmanial Agents

Pharmaceuticals, 2023
A series of rosmarinic acid-β-amino-α-ketoamide hybrids were synthesized and rationally repurposed towards the identification of new antileishmanial hit compounds.
Ahmed H.E. Hassan, Waleed A. Bayoumi, Selwan M. El-Sayed, Trong-Nhat Phan, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud, Joo Hwan No, Yong Sup Lee   +8 more
doaj   +1 more source

Advances in Understanding Leishmania Pathobiology: What Does RNA-Seq Tell Us?

Frontiers in Cell and Developmental Biology, 2021
Leishmaniasis is a vector-borne disease caused by a protozoa parasite from over 20 Leishmania species. The clinical manifestations and the outcome of the disease vary greatly.
Tamara Salloum, Sima Tokajian, Robert P. Hirt   +2 more
doaj   +1 more source

Canine experimental infection: intradermal inoculation of Leishmania infantum promastigotes

Memorias do Instituto Oswaldo Cruz, 2000
Five mixed breed dogs were inoculated intradermally (ID) with cultured virulent stationary phase promastigotes of Leishmania infantum Nicole, 1908 stocks recently isolated.
Gabriela M Santos-Gomes, Lenea Campino, Pedro Abranches   +2 more
doaj   +1 more source

Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A rational-based process was adopted for repurposing pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs bearing variable acyl chains, different stereochemical configuration and/or positional relationships.
Ahmed H. E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seung-Hwan Kim, Joo Hwan No, Yong Sup Lee   +7 more
doaj   +1 more source

In Vitro Antileishmanial and Antischistosomal Activities of Anemonin Isolated from the Fresh Leaves of Ranunculus multifidus Forsk

Molecules, 2021
Leishmaniasis and schistosomiasis are neglected tropical diseases (NTDs) infecting the world’s poorest populations. Effectiveness of the current antileishmanial and antischistosomal therapies are significantly declining, which calls for an urgent need of
Betelhem Sirak, Kaleab Asres, Asrat Hailu, Mthandazo Dube, Norbert Arnold, Cecile Häberli, Jennifer Keiser, Peter Imming   +7 more
doaj   +1 more source

In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi Eficácia in vitro de Coriandrum sativum, Lippia sidoides e Copaifera reticulata sobre Leishmania chagasi

Revista Brasileira de Parasitologia Veterinária, 2012
The increased incidence of visceral leishmaniasis (VL) in Brazil is due to a lack of effective disease control measures. In addition to that, no effective treatment exists for canine VL in response to synthetic drugs.
Fernanda Cristina Macedo Rondon, Claudia Maria Leal Bevilaqua, Marina Parissi Accioly, Selene Maia de Morais, Heitor Franco de Andrade-Júnior, Camila Aparecida de Carvalho, Josemar Coelho Lima, Hilton César Rodrigues Magalhães   +7 more
doaj   +1 more source