Results 71 to 80 of about 7,503 (174)

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Growth monitoring and cell cycle analysis of L. infantum HIFBS-depleted promastigotes and CM promastigotes.

, 2016
(A) Average growth curves of three replicate cultures of HIFBS-depleted and CM L. infantum promastigotes. Cell density was registered daily in a Neubauer chamber at the light microscope (40 X).
María A. Degayón (2557552), Ana Alonso (673057), Inmaculada Moreno (245777), Pedro J. Alcolea (553038), Miguel A. Moreno-Izquierdo (2557555), Vicente Larraga (238914)   +5 more
core   +1 more source

Oxidant-mediated damage of Leishmania donovani promastigotes [PDF]

Infection and Immunity, 1982
Dissemination of Leishmania within the host is related to parasites undergoing unchecked proliferation. We therefore studied the effects of oxidant generating systems on promastigote multiplication by (i) direct determinations of organism proliferation and (ii) the incorporation of [3H]uracil into promastigote nucleoprotein.
N E, Reiner, J W, Kazura
openaire   +2 more sources

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

ATG5 puncta in L. major promastigotes.

, 2012
(A) The occurrence of mC-ATG5 puncta in WT L. major promastigotes expressing mC-ATG5 incubated in nutrient-rich medium at log phase at 26°C. (B) The multiplicity of puncta in promastigotes expressing mC-ATG5 after starvation for up to 1 h in PBS at 26°C.
Jeremy C. Mottram (112563), Graham H. Coombs (164011), Roderick A. M. Williams (164005), Terry K. Smith (112550), Benjamin Cull (164010)   +4 more
core   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Leishmania mexicana: promastigotes migrate through osmotic gradients

, 2002
During the insect phase of the parasite lifecycle, Leishmania promastigotes move from the midgut to the anterior regions of the alimentary tract of their sandfly vector.
Barrett, M., Burchmore, R., Leslie, G.
core   +1 more source

Translational Pharmacokinetic‐Pharmacodynamic Modeling and Efficacious Human Dose Prediction of DNDI‐6148 for the Treatment of Cutaneous Leishmaniasis

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Cutaneous leishmaniasis is a neglected tropical disease with only one oral treatment option. DNDI‐6148 is an orally bioavailable compound with potent antiparasitic activity in preclinical studies. Establishing skin target‐site pharmacokinetic/pharmacodynamic (PK/PD) relationships is essential to enable its clinical development.
Rasmus Hansen Henninger, Wietse M. Schouten, Byron Arana, Jean‐Yves Gillon, Charles E. Mowbray, Jadel Müller Kratz, Katrien Van Bocxlaer, Thomas P. C. Dorlo   +7 more
wiley   +1 more source

The Regulatory Effect of Histone Deacetylase (HDAC) 1 and 2 on iNOS, IL‐6, TNF‐α and IL‐10 Expression in Canine Macrophages Infected With Leishmania infantum

Parasite Immunology, Volume 48, Issue 4, April 2026.
ABSTRACT Zoonotic visceral leishmaniasis is caused by Leishmania (Leishmania) infantum. Dogs are considered the most critical urban reservoirs of L. (L.) infantum due to their high infection rate and direct transmission to humans. The parasite has developed mechanisms to evade the host's defence system by inhibiting macrophage activation, thereby ...
Gabriela Lovizutto Venturin, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Gabriela Torres Rebech, Flávia Lombardi Lopes, Valéria Marçal Felix de Lima   +5 more
wiley   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source