Results 171 to 180 of about 11,890 (215)

Regulation of Proopiomelanocortin Gene Expression in Pituitary

Endocrine Reviews, 1988
I. Introduction THE POMC gene encodes the complex precursor to a variety of biologically active, important neuromodulator and endocrine peptides. It is expressed in a variety of tissues in the mammal, but its main site of expression is the pituitary anterior lobe cortocotroph and intermediate lobe melanotroph.
J R, Lundblad, J L, Roberts
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Proopiomelanocortin and the Immune‐Neuroendocrine Connection

Annals of the New York Academy of Sciences, 1999
ABSTRACT:This presentation will cover the history, recent developments in, and implications of the ability of both the immune and neuroendocrine systems to produce POMC. The discovery of POMC in immune cells was one of the events that heralded a molecular understanding of neuroimmunomodulation.
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Regulation of Testicular Proopiomelanocortin Gene Expression*

Endocrinology, 1987
The POMC gene is expressed in testicular Leydig cells, but its mRNA is about 150-200 nucleotides shorter in these cells than in the pituitary. For this reason this testicular mRNA has been termed POMC-like mRNA. The purpose of the present study was to define the ontogeny and regulation of POMC gene expression in rat testis.
C L, Chen, M B, Madigan
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From Proopiomelanocortin to Cancer

Annals of the New York Academy of Sciences, 1993
Melanophore-stimulating hormones (MSHs) are produced from a common precursor called proopiomelanocortin (POMC). These peptides have been at the center of studies on the prohormone theory since 1967. The recent discovery of endoproteases which can convert POMC to MSHs is having more biological implications than previously imagined, most particularly for
M, Mbikay, N G, Seidah, M, Chretien
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Molecular Cloning of Lungfish Proopiomelanocortin cDNA

General and Comparative Endocrinology, 1999
To investigate the evolution of proopiomelanocortin (POMC) from fish to tetrapods, nucleotide sequence of POMC cDNA from a lobe-finned fish, the African lungfish, was determined. POMC cDNA was prepared from lungfish pituitary glands. The POMC cDNA is composed of 1114 bp, excluding a poly-A tail, and encodes 255 amino acids (aa) including a signal ...
Y, Amemiya, A, Takahashi, H, Meguro, H, Kawauchi   +3 more
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Ectopic Secretion of Peptides of the Proopiomelanocortin Family

Endocrinology and Metabolism Clinics of North America, 1991
A wide spectrum of clinical and biochemical presentations characterize ectopic POMC syndrome. It is presently postulated that ectopic POMC production results from increased expression of the activity of a POMC gene normally occurring in a variety of tissues outside the pituitary gland.
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PROOPIOMELANOCORTIN‐DERIVED PEPTIDES IN THE IMMUNE SYSTEM

Clinical Endocrinology, 1985
SUMMARYCells of the immune system have recently been recognized as a source of the proopiomelanocortin (POMC)‐derived peptides, ACTH and endorphins, and their receptors. In this review, the nature of the immunoregulatory and hypothalamic signals which elicit the production of these leukocyte‐derived hormones is discussed.
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Proopiomelanocortin and Related Hormones

2010
The cutaneous proopiomelanocortin (POMC) system is an important regulatory system, which controls pigmentation, inflammation, and the stress response of the skin. Based on their potent melanotropic effects, selected melanocortin peptides derived from POMC have been tested in the past for their efficacy in vitiligo.
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Proopiomelanocortin and the Melanocortin Peptides

2000
The “melanophore stimulants” were discovered about 80 yr ago when, with surgical ablation experiments, the pituitary gland was shown to be involved in the control of skin color of amphibia. The pars intermedia was soon recognized as the origin of the biological principle, then also named “intermedin,” which induced darkening of amphibian skin (for a ...
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Proopiomelanocortin gene expression in man

2003
Proopiomelanocortin (POMC) is the polypeptide precursor to ACTH and several other biologically active peptides.
Yves de Keyzer, Marie-Laure Raffin-Sanson, Xavier Bertagna   +2 more
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