Results 161 to 170 of about 11,890 (215)
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The Proopiomelanocortin System
Annals of the New York Academy of Sciences, 1999ABSTRACT: POMC (31,000 MW) is localized to the pituitary, brain, skin, and other peripheral sites. The particular enzyme profile present within a cell dictates the nature of the hormonal ligand (melanocortin) synthesized and secreted: melanotropic peptides (α‐MSH β‐lipotropin, λ‐MSH), corticotropin (ACTH), several endorphins (e.g., met‐enkephalin ...
M E, Hadley, C, Haskell-Luevano
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Proopiomelanocortin Peptides and Sebogenesis
Annals of the New York Academy of Sciences, 2003Abstract: Previous animal studies have demonstrated that α‐melanocyte‐stimulating hormone (α‐MSH) is a sebotropic hormone in rats and that targeted disruption of melanocortin 5 receptor (MC5‐R) can down‐regulate sebum output in mice. To study the role of proopiomelanocortin (POMC) peptides in the regulation of human sebaceous lipid production and ...
Li, Zhang +4 more
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Evolutionary significance of proopiomelanocortin in agnatha and chondrichthyes
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2001Hiroshi Kawauchi +2 more
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Mutations in the Human Proopiomelanocortin Gene
Annals of the New York Academy of Sciences, 2003Abstract: The melanocortin peptides and their receptors represent one of the most complex systems in human endocrinology. Hormonal regulation includes pigmentation, weight maintenance, adrenal function, and exocrine gland secretion via endocrine, paracrine, autocrine, and neurocrine action of melanocortin peptides at five different but homologous ...
Heiko, Krude +2 more
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Trends in the evolution of the proopiomelanocortin gene
General and Comparative Endocrinology, 2005The POMC gene is perhaps the most extensively studied member of the opioid/orphanin gene family. In Phylum Chordata this gene has been characterized in representatives of every class within the Gnathostomata, as well as in one representative agnathan vertebrate, the marine lamprey.
Robert M, Dores, Stephanie, Lecaude
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Glucocorticoid Regulation of Hypothalamic Proopiomelanocortin
Neuroendocrinology, 1998Although glucocorticoids clearly inhibit proopiomelanocortin (POMC) gene transcription and peptide synthesis in the anterior pituitary, the effects of glucocorticoids on POMC in the hypothalamus are still unclear, even though most POMC neurons in the arcuate nucleus are known to have glucocorticoid receptors.
S L, Wardlaw +2 more
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The Journal of Immunology, 1997
Abstract This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.
M, Salzet +7 more
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Abstract This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.
M, Salzet +7 more
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Proopiomelanocortin-Derived Peptides
Endocrinology and Metabolism Clinics of North America, 1994Cloning of the cDNA of POMC mRNA led to the characterization of the ACTH precursor and established the molecular links between ACTH, beta LPH and gamma LPH, and beta end. Further previously unidentified POMC-derived peptides were also unravelled, including the N-terminal fragment and the JP.
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1987
Proopiomelanocortin (POMC) is the name given to the protein precursor for both s-endorphin and adrenocorticotropin (ACTH). Although the proof of a common precursor for these important peptides was provided by chemical evidence (1–3), the elucidation of the exact structure of POMC and the prediction of other biologically important peptides in the same ...
Michael Uhler, Edward Herbert
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Proopiomelanocortin (POMC) is the name given to the protein precursor for both s-endorphin and adrenocorticotropin (ACTH). Although the proof of a common precursor for these important peptides was provided by chemical evidence (1–3), the elucidation of the exact structure of POMC and the prediction of other biologically important peptides in the same ...
Michael Uhler, Edward Herbert
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Synthesis and Glycosylation of Proopiomelanocortin by a Cushing Tumor*
The Journal of Clinical Endocrinology & Metabolism, 1982ACTH derives from a larger protein, proopiomelanocortin (POMC), which is also the precursor to lipotropin, endorphin, melanotropin, and other peptides. The sequence of steps by which POMC is processed to ACTH has been delineated in detail in cultured mouse tumor cells, but little is known about these steps in human pituitary adenomas.
W L, Miller, L K, Johnson
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