Results 91 to 100 of about 11,905 (245)

Study of the variables associated with local complement activation in IgA nephropathy

Nefrología (English Edition), 2017
Objectives: 1. To identify the variables that are associated with urinary levels of properdin, MBL, C4d, and C5b-9 in patients with idiopathic IgA nephropathy. 2. To analyse whether urinary levels of MBL and/or C4d are useful for identifying the presence
Alfons Segarra-Medrano, Clara Carnicer-Caceres, Naiara Valtierra-Carmeno, Irene Agraz-Pamplona, Natalia Ramos-Terrades, Elías Jatem Escalante, Elena Ostos-Roldan   +6 more
doaj   +1 more source

The complement system: A key player in the host response to infections

European Journal of Immunology, Volume 54, Issue 11, November 2024.
Duality of the complement system during infection: An adequate immune defense clears the infection and restores tissue resilience, whereas a maladaptive response due to complement hyperactivation results in hyperinflammation and tissue injury, as seen in sepsis and pneumonia.
Archana Jayaraman, Sarah Walachowski, Markus Bosmann   +2 more
wiley   +1 more source

Biotic and abiotic factors of bactericidal properties variability of ruminant saliva

BIO Web of Conferences, 2020
The microflora of the oral cavity of domestic ruminants, presented by transitive gram-negative species of bacteria (cocci and sticks) in cows, transient and obligate gram-positive (usually cocci) bacteria in sheep was studied. The lowest contamination of
Gilmutdinov Rustam Y., Spiridonov Gennady N., Shalamova Guzel G., Pokrovskaya Ekaterina S.   +3 more
doaj   +1 more source

QUANTITATIVE STUDIES ON THE PROPERDIN-COMPLEMENT SYSTEM [PDF]

The Journal of Experimental Medicine, 1956
Quantitative methods have been developed for the estimation of C'3 and properdin. With these methods, the kinetics of the over-all reaction between properdin, zymosan, and C'3 were investigated. The reaction followed first order kinetics, provided zymosan was in excess, and the serum not diluted beyond 1/4.
openaire   +6 more sources

The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions

MedComm, Volume 5, Issue 11, November 2024.
Understanding the alterations in complement and coagulation systems could aid in the creation of novel therapeutic approaches to tackle the dysfunction of complement and coagulation in diseases. The unacceptably high mortality rate of sepsis has prompted further research into the molecular pathogenesis of sepsis and therapeutic interventions.
Honghong Jiang, Yiming Guo, Qihang Wang, Yiran Wang, Dingchuan Peng, Yigong Fang, Lei Yan, Zhuolin Ruan, Sheng Zhang, Yong Zhao, Wendan Zhang, Wei Shang, Zhichun Feng   +12 more
wiley   +1 more source

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B [PDF]

, 1980
Serum protein types were determined in eight recipients and donors in cases of hepatic homotransplantation. A change from recipient type to donor type was observed for factor B, C8, orosomucoid, haptoglobin, transferrin, α1-antitrypsin, C3 and C6, but ...
Alper, Alper, Alper, Alper, Borel, Brade, Bruce H. Petersen, Chester A. Alper, Donald Raum, Einstein, Frants, Hirschfeld, Hobart, Hobart, Johnson, Kashiwagi, Kashiwagi, Kühnl, Merrill, Miller, Miller, Paul D. Taylor, Petersen, Raum, Rother, Smithies, Starzl, Thomas E. Starzl, Witherspoon, Zuheir L. Awdeh   +29 more
core   +1 more source

Visualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis

Muscle &Nerve, Volume 70, Issue 4, Page 851-861, October 2024.
Plasma C3a and sC5b‐9 are promising blood biomarkers with very high sensitivity and specificity for complement activation in myasthenia gravis (MG). Further, the in vitro study supported membrane attack complex deposition after applying AChR+ MG sera on human muscle cells.
Yu‐Fang Huang, Kerstin Sandholm, Barbro Persson, Bo Nilsson, Anna Rostedt Punga   +4 more
wiley   +1 more source

Properdin Levels in Splenectomized Persons

Experimental Biology and Medicine, 1959
SummaryProperdin titers were definitely lower in 105 splenectomized persons than in 113 normal; healthy subjects. Within the splenectomized group, there was no correlation between properdin level and age of individual, age at splenectomy, and years post-splenectomy.
Harold N. Carlisle, Samuel Saslaw
openaire   +3 more sources

Therapeutic targeting of factor D and MASP3 in complement‐mediated diseases: Lessons learned from mouse studies

European Journal of Immunology, Volume 54, Issue 9, September 2024.
Factor D (FD) and MASP3 are two proteases that are critical for alternative pathway complement activation and represent attractive therapeutic targets for complement‐mediated human diseases. Abstract The alternative pathway (AP) plays a major role in many complement‐mediated human diseases.
Eshagh Mohammadyari, Takashi Miwa, Madhu Golla, Wen‐Chao Song   +3 more
wiley   +1 more source

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]

, 2016
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel, Aso, Hisashi, Ikeda-Ohtsubo, Wakako, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Kobayashi, Hisakazu, Kober, Humayun A.K.M., Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Saito, Tadao, Sato, Nana, Suda, Yoshihito, Villena, Julio Cesar   +14 more
core   +1 more source