Results 91 to 100 of about 10,092 (236)
Glia, Volume 72, Issue 12, Page 2295-2312, December 2024.Main Points Hyposialylation in Gne+/‐ mice induced loss of retinal rod bipolar cells. Hyposialylation triggered complement, inflammation and apoptosis transcriptome pathways in the retina. Crossing Gne+/‐ with C3‐deficient mice prevented the retinal changes.
German Cuevas‐Rios +6 more
wiley +1 more source
Frontiers in Endocrinology, 2018 BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler +11 more
doaj +1 more source
The Journal of Dermatology, Volume 51, Issue 12, Page 1665-1668, December 2024.Abstract Pemphigus vulgaris (PV) is a severe autoimmune bullous dermatosis that is characterized by autoantibodies against epidermal adhesion proteins causing painful mucosal and skin blistering. Standard treatments for PV include corticosteroids, steroid‐sparing immunosuppressants, or intravenous monoclonal anti–CD20‐antibody therapy.
Nadine Wiedenmayer +4 more
wiley +1 more source
Biotic and abiotic factors of bactericidal properties variability of ruminant saliva
BIO Web of Conferences, 2020 The microflora of the oral cavity of domestic ruminants, presented by transitive gram-negative species of bacteria (cocci and sticks) in cows, transient and obligate gram-positive (usually cocci) bacteria in sheep was studied. The lowest contamination of
Gilmutdinov Rustam Y. +3 more
doaj +1 more source
The complement system: A key player in the host response to infections
European Journal of Immunology, Volume 54, Issue 11, November 2024.Duality of the complement system during infection: An adequate immune defense clears the infection and restores tissue resilience, whereas a maladaptive response due to complement hyperactivation results in hyperinflammation and tissue injury, as seen in sepsis and pneumonia.
Archana Jayaraman +2 more
wiley +1 more source
Nature Communications, 2016 Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang +5 more
doaj +1 more source
MedComm, Volume 5, Issue 11, November 2024.Understanding the alterations in complement and coagulation systems could aid in the creation of novel therapeutic approaches to tackle the dysfunction of complement and coagulation in diseases. The unacceptably high mortality rate of sepsis has prompted further research into the molecular pathogenesis of sepsis and therapeutic interventions.
Honghong Jiang +12 more
wiley +1 more source
Frontiers in Immunology, 2018 Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli +9 more
doaj +1 more source
The Properdin System: Composition and Function [PDF]
Vox Sanguinis, 1978 Abstract.This article summarizes the physicochemical data on the factors which compose the properdin system in guinea pig and man. The following other topics are discussed: (1) Activation of the properdin system; (2) Formation of the initiating and amplification C3 convertases; (3) Formation of the C5 convertase, and (4) Regulatory control mechanisms ...
openaire +3 more sources
Muscle &Nerve, Volume 70, Issue 4, Page 851-861, October 2024.Plasma C3a and sC5b‐9 are promising blood biomarkers with very high sensitivity and specificity for complement activation in myasthenia gravis (MG). Further, the in vitro study supported membrane attack complex deposition after applying AChR+ MG sera on human muscle cells.
Yu‐Fang Huang +4 more
wiley +1 more source