Results 11 to 20 of about 177,045 (348)

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Nature, 2022
The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate1. Regenerative ability is influenced by both injury-dependent and injury-independent mechanisms2.
, Guiping Kong, Luming Zhou
exaly   +2 more sources

Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

Nature Communications, 2021
We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by nuclear magnetic resonance using [13C]-inositols, mass spectrometry and ...
Nam Bui, Robert Puschmann, Sjef Boeren
exaly   +2 more sources

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Journal of Biological Chemistry, 2003
GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice.
Andrew J Brown, Mark J Wigglesworth, Fiona H Marshall   +2 more
exaly   +2 more sources

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Nature Communications, 2020
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism.
Antonio Molinaro, Pierre Bel Lassen, Marcus Ståhlman   +2 more
exaly   +2 more sources

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

Gut, 2019
Objective To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses. Design
Edward S Chambers, Claire S Byrne, Douglas J Morrison   +2 more
exaly   +2 more sources

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

Science Translational Medicine, 2019
Propionate activates the insulin counter-regulatory hormonal response in mice, resulting in insulin resistance and weight gain. A metabolic dysregulator in hiding Propionate is a short-chain fatty acid that is a commonly used food preservative. Tirosh et
Amir Tirosh, Ediz S Calay, Gurol Tuncman
exaly   +2 more sources

Propionate alleviates fatty acid–induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes

Journal of Dairy Science, 2022
: Reduced feed intake during the transition period renders cows unable to meet their energy needs for maintenance and lactation, leading to a state of negative energy balance.
Xinghui Wang, Mengyao Zhu, Juan J. Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei Li   +12 more
doaj   +2 more sources

Propionate-Producing Consortium Restores Antibiotic-Induced Dysbiosis in a Dynamic in vitro Model of the Human Intestinal Microbial Ecosystem

Frontiers in Microbiology, 2019
Metabolic syndrome is a growing public health concern. Efforts at searching for links with the gut microbiome have revealed that propionate is a major fermentation product in the gut with several health benefits toward energy homeostasis.
Racha El Hage, Emma Hernandez-Sanabria, Marta Calatayud Arroyo, Ruben Props, Tom Van de Wiele   +4 more
doaj   +2 more sources

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

PLoS ONE, 2012
Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are metabolites formed by gut microbiota from complex dietary carbohydrates.
H. Lin, A. Frassetto, Edward J. Kowalik Jr, A. Nawrocki, Mofei M. Lu, Jennifer R. Kosinski, J. Hubert, Daphne Szeto, X. Yao, Gail Forrest, D. Marsh   +10 more
exaly   +2 more sources

Formation of propionate and butyrate by the human colonic microbiota

Environmental Microbiology, 2017
Petra Louis, Harry J Flint
exaly   +2 more sources