Results 61 to 70 of about 177,045 (348)

Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Biomolecules
Background: Reduced short-chain fatty acids (SCFAs) in inflammatory bowel disease (IBD) impair the gut barrier and immune function, promoting inflammation and highlighting microbiome-targeted therapies’ therapeutic potential.
Laura Chulenbayeva, Zharkyn Jarmukhanov, Karlygash Kaliyekova, Samat Kozhakhmetov, Almagul Kushugulova   +4 more
doaj   +1 more source

The Association Between Changes in Plasma Short-Chain Fatty Acid Concentrations and Hypertension in Children With Chronic Kidney Disease

Frontiers in Pediatrics, 2021
Background: Some children with chronic kidney disease (CKD) develop hypertension faster than others. This may be attributable to endothelial dysfunction, among other reasons.
Pei-Chen Lu, Pei-Chen Lu, Chien-Ning Hsu, I-Chun Lin, Mao-Hung Lo, Ming-Yu Yang, You-Lin Tain, You-Lin Tain   +7 more
doaj   +1 more source

Propionate Protects Haloperidol-Induced Neurite Lesions Mediated by Neuropeptide Y

Frontiers in Neuroscience, 2018
Haloperidol is a commonly used antipsychotic drug for treating schizophrenia. Clinical imaging studies have found that haloperidol can cause volume loss of human brain tissue, which is supported by animal studies showing that haloperidol reduces the ...
Minmin Hu, Minmin Hu, Peng Zheng, Yuanyi Xie, Zehra Boz, Yinghua Yu, Renxian Tang, Alison Jones, Kuiyang Zheng, Xu-Feng Huang   +9 more
doaj   +1 more source

Short chain fatty acids: the messengers from down below

Frontiers in Neuroscience, 2023
Short-chain fatty acids (SCFAs), produced by the metabolism of dietary fibers in the gut, have wide-ranging effects locally and throughout the body. They modulate the enteric and central nervous systems, benefit anti-inflammatory pathways, and serve as ...
Virginie Mansuy-Aubert, Yann Ravussin
doaj   +1 more source

Intestinal Bacteroides modulates inflammation, systemic cytokines, and microbial ecology via propionate in a mouse model of cystic fibrosis

mBio
Persons with cystic fibrosis (CF), starting in early life, show intestinal microbiome dysbiosis characterized in part by a decreased relative abundance of the genus Bacteroides.
Courtney E. Price, R. Valls, A. Ramsey, N. Loeven, Jane T. Jones, Kaitlyn E. Barrack, J. Schwartzman, D. Royce, R. Cramer, J. Madan, Benjamin D. Ross, J. Bliska, George A. O'Toole   +12 more
semanticscholar   +1 more source

Enrichment and description of novel bacteria performing syntrophic propionate oxidation at high ammonia level.

Environmental Microbiology, 2021
Inefficient syntrophic propionate degradation causes severe operating disturbances and reduces biogas productivity in many high-ammonia anaerobic digesters, but propionate-degrading microorganisms in these systems remain unknown.
Abhijeet Singh, A. Schnürer, M. Westerholm   +2 more
semanticscholar   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

Angewandte Chemie, EarlyView.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang, Lei Wang, Marco Hadisurya, Siavash Shahbazi Nia, W. Andy Tao, Emily C. Dykhuizen, Casey J. Krusemark   +6 more
wiley   +2 more sources