Results 51 to 60 of about 160,774 (308)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial

Efficacy and Mechanism Evaluation
Background Overweight and obesity affect over 60% of the United Kingdom population and constitute a major risk factor for the development of comorbidities.
Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison   +16 more
doaj   +1 more source

Short chain fatty acids: the messengers from down below

Frontiers in Neuroscience, 2023
Short-chain fatty acids (SCFAs), produced by the metabolism of dietary fibers in the gut, have wide-ranging effects locally and throughout the body. They modulate the enteric and central nervous systems, benefit anti-inflammatory pathways, and serve as ...
Virginie Mansuy-Aubert, Yann Ravussin
doaj   +1 more source

Electrolyte Design for Fast‐Charging Lithium‐Based Batteries

Advanced Materials, EarlyView.
A decade of progress in fast‐charging electrolytes for lithium batteries is reviewed. Electrolyte design strategies spanning solvents, salts, additives, and advanced systems, such as localized high‐concentration electrolytes (LHCEs), are summarized. Advanced diagnostic tools for lithium plating and interphase chemistry are discussed, with perspectives ...
Chen Liu, Zehao Cui, Arumugam Manthiram
wiley   +1 more source

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source

Propionate alleviates fatty acid–induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes

Journal of Dairy Science, 2022
: Reduced feed intake during the transition period renders cows unable to meet their energy needs for maintenance and lactation, leading to a state of negative energy balance.
Xinghui Wang, Mengyao Zhu, Juan J. Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei Li   +12 more
doaj   +1 more source

Inhibition kinetics for propionate degradation using propionate-enriched mixed cultures

, 1998
To study propionate inhibition kinetics, seed cultures for the experiment were obtained from a propionate-enriched steady-state anaerobic Master Culture Reactor (MCR) operated under a semi-continuous mode for over six months.
J. C. Young, S. H. Hyun, I. S. Kim
core   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

Monolithic Porous Polymer Architectures for Visible‐to‐UV Upconversion‐Driven Photochemical Reactions

Angewandte Chemie, EarlyView.
Porous polymer monoliths embedded with sensitizer–annihilator dye pairs enable efficient solid‐state visible‐to‐ultraviolet triplet–triplet annihilation‐based photon upconversion under low‐intensity blue and green light. Their co‐continuous porous architectures balance chromophore interactions with substrate accessibility, providing robust and tunable ...
Sakura Nakagawa, Naoto Matsumoto, Masanori Uji, Maria‐Sophie Bertrams, Christoph Kerzig, Nobuhiro Yanai   +5 more
wiley   +2 more sources

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source