Results 71 to 80 of about 218,446 (354)

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Descriptive Analysis of the Relationship Between Continuous Intravenous Insulin Infusion and Triglyceride Levels in Critically Ill Patients Receiving Propofol Infusion

Anesthesia Research
Background/Objectives: Propofol is a preferred agent for ICU sedation. Hypertriglyceridemia occurs in up to 45% of patients on propofol and has been linked with adverse effects.
Sarah R. Peppard, Jayshil J. Patel
doaj   +1 more source

Propofol inhibits proliferation and metastasis by up-regulation of miR-495 in JEG-3 choriocarcinoma cells

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Choriocarcinoma is a rare gestational trophoblastic tumour. Propofol is one of the commonly used intravenous anaesthetic agents and exerts an anti-tumour role in multiple cancers.
Hai Sun, Yingjian Wang, Wenyu Zhang
doaj   +1 more source

Does memory priming during anesthesia matter? [PDF]

, 2005
This editorial argues that there is evidence for memory priming during adequate anaesthesia, and that research in the field of social cognition suggests that such priming may have important behavioural consequences.
Andrade, J.
core   +1 more source

Propofol for Treatment-Resistant Depression: A Pilot Study

International Journal of Neuropsychopharmacology, 2018
Background We hypothesized that propofol, a unique general anesthetic that engages N-methyl-D-aspartate and gamma-aminobutyric acid receptors, has antidepressant properties.
B. J. Mickey, B. J. Mickey, Andrea T. White, Anna M Arp, K. Leonardi, Marina M Torres, Adam Larson, D. Odell, Sara A Whittingham, Michael M. Beck, Jacob E. Jessop, D. Sakata, Lowry Bushnell, Matthew D Pierson, Daniela Solzbacher, E. Kendrick, H. Weeks, A. Light, Kathleen C. Light, S. Tadler   +19 more
semanticscholar   +1 more source

First Successful Regeneration of a Structurally Native‐Like Colon Using a Bioabsorbable Polymer Sheet

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrated that a bioabsorbable polymer sheet (BAPS) can regenerate approximately half the circumference of the colon with native‐like structure and function in an experimental setting. As the model involved immediate closure after perforation and did not reproduce peritonitis, caution is required when considering clinical applicability ...
Junpei Takashima, Mitsuo Miyazawa, Masayasu Aikawa, Daisuke Fujimoto, Hirotoshi Kobayashi   +4 more
wiley   +1 more source

A Soft‐Tip Hydraulically Steerable Catheter for Enhanced Flexibility and Safety in Vascular Interventions

Advanced Intelligent Systems, EarlyView.
This study introduces a hydraulically steerable catheter with a soft tip in vascular procedures. The steering soft tip achieves a minimal diameter of 2.6 mm and supports a 180° bend. Real‐time shape and position tracking, facilitated by segmentation and endpoint detection techniques, improves navigation.
Jingyi Kang, Ye Wang, Jiayuan Liu, Zhuhao Wang, Xuan Yang, Jie Wang, Jian Wu, Guochen Ning, Boyu Zhang, Hongen Liao   +9 more
wiley   +1 more source

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study

Korean Journal of Anesthesiology, 2016
Background The optimal combination of anesthetic agent and technique may have an influence on long-term outcomes in cancer surgery. In vitro and in vivo studies suggest that propofol independently reduces migration of cancer cells and metastasis.
Ji Heui Lee, S. Kang, Yunkwang Kim, H. A. Kim, Bongseog Kim   +4 more
semanticscholar   +1 more source

Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness

Advanced Intelligent Systems, EarlyView.
Intravascular electroencephalography (ivEEG) using micro‐intravascular electrodes was developed. Cortical‐vein ivEEG showed a higher signal‐to‐noise ratio and finer spatial resolution of somatosensory evoked potentials (SEPs) than superior sagittal sinus ivEEG, and deep‐vein ivEEG captured clear visual evoked potentials.
Takamitsu Iwata, Hajime Nakamura, Takafumi Uemura, Teppei Araki, Takaki Matsumura, Takaaki Abe, Toshikazu Nezu, Masatoshi Takagaki, Tomohiko Ozaki, Shinpei Miura, Ryohei Fukuma, Sam E. John, David B. Grayden, Haruhiko Kishima, Tsuyoshi Sekitani, Takufumi Yanagisawa   +15 more
wiley   +1 more source