Results 171 to 180 of about 36,320 (224)

Metabolism of prostacyclin in rat

Biochemistry, 1978
Following a single intravenous administration of [11-3H]prostacyclin in rat, 77% of the administered dose was excreted within 3 days with 33% in urine and 44% in feces. Urinary metabolites were accumulated by chronic intravenous infusions of [11-3H]prostacyclin for 14 days.
F F, Sun, B M, Taylor
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Prostacyclin is not a circulating hormone

Prostaglandins, 1981
Gas chromatography with electron-capture detection of the extensively purified pentafluorobenzyl derivative of 6-oxo-PGF1 alpha was used to determine prostacyclin in blood. Neither human peripheral plasma or whole blood, nor blood drawn directly from the human heart (blood from the right and left atrium which is comparable to pulmonary artery and vein ...
E, Christ-Hazelhof, D H, Nugteren
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Prostacyclin in hypertension.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991
Prostacyclin (PGI2) is known to cause vasorelaxation and inhibit platelet aggregation by receptor-mediated mechanisms. While cyclic (c)AMP is known to act as a second messenger for platelet aggregation, vasorelaxation by hyperpolarization has been described only recently and may provide an explanation, in addition to stimulation of cAMP, for the PGI2 ...
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Prostacyclin is a circulating hormone

Nature, 1978
PROSTACYCLIN (PGI2) is generated by vascular walls from arachidonic acid or prostaglandin endoperoxides1. It is the most potent inhibitor of platelet aggregation so far described, and acts by increasing cyclic AMP in the platelets2,3, presumably through adenyl cyclase stimulation.
S, Moncada, R, Korbut, S, Bunting, J R, Vane   +3 more
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Prostacyclin in Moscow

Cardiovascular Research, 2023
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Prostacyclin‐analogs

Medicinal Research Reviews, 1985
R C, Nickolson, M H, Town, H, Vorbrüggen   +2 more
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Prostacyclin (PGI2)

Intensive Care Medicine, 1983
S C, Davies, S J, Machin
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Prostacyclin

1981
J R, Vane, S, Moncada
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Neuronal prostacyclin receptors

1997
Prostacyclin is primarily derived from vascular endothelium and has traditionally been regarded as an important regulator of haemostasis due to its potent anti-platelet and vasodilator activity [1]. However, prostacyclin has additional biological activity mediated by receptors located in both the peripheral and central nervous system (CNS), and it is ...
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Prostacyclin

Drugs of the Future, 1977
J. Castañer, K. Hillier
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