Results 51 to 60 of about 36,320 (224)

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

The future of prostacyclin

, 2015
The discovery of prostaglandin in 1976 revolutionized the treatment of a rare cardiovascular condition called pulmonary arterial hypertension. However, current treatments are plagued by many unwanted side effects, and so its full therapeutic potential ...
Nature Research (16552612)
core   +1 more source

Functional Prostacyclin Synthase Promoter Polymorphisms. Impact in Pulmonary Arterial Hypertension [PDF]

, 2014
RationalePulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary artery pressure, vascular remodeling, and ultimately right ventricular heart failure. PAH can have a genetic component (heritable PAH), most often
Del Rosario, Mark J, Fettig, Lynsey M, Cornelius, Amber R, Taylor, Matthew R, Loyd, James E, Lu, Xiao, Wong, Randall E, Cogan, Joy D, Graham, Brian B, Tuder, Rubin M, Hara, Naoko, Lowe, Anita M, Geraci, Mark W, Stearman, Robert S, Elos, Mihret T, Conklin, David S, Phillips, John A   +16 more
core   +1 more source

Health-related quality of life burden in scleroderma patients treated with two different intravenous iloprost regimens

Reumatismo, 2019
Systemic sclerosis (SSc)-related Raynaud’s phenomenon (RP) and digital ulcers (DU) can impair health-related quality of life (HRQoL). The aim of our study was to estimate HRQoL in SSc patients treated with two different intravenous (IV) iloprost (ILO ...
T. Schioppo, L. Scalone, P. Cozzolino, L. Mantovani, G. Cesana, O. De Lucia, A. Murgo, F. Ingegnoli   +7 more
doaj   +1 more source

Vasorelaxant Effects of Syzygium samarangense (Blume) Merr. and L.M.Perry Extract Are Mediated by NO/cGMP Pathway in Isolated Rat Thoracic Aorta

Pharmaceuticals, 2022
Syzygium samarangense (Blume) Merr. and L.M.Perry is utilized widely in traditional medicine. We have reported previously a wide array of pharmacological properties of its leaf extract, among them anti-inflammatory, antioxidant, hepatoprotective ...
Noura A. Hassan, Mohamed A. O. Abdelfattah, Yasmine M. Mandour, Assem M. El-Shazly, Mansour Sobeh, Mona F. Mahmoud   +5 more
doaj   +1 more source

Effect of Magnesium Sulfate (MgSO4) Administration on Nitric Oxide and Prostacyclin Levels in Preeclampsia

Andalas Obstetrics and Gynecology Journal
Introduction :  Preeclampsia is a pregnancy-related syndrome with significant maternal and neonatal risks, affecting 4.6% of pregnancies globally.
Evert Pangkahila, Kade Yudi Saspriyana, Clara Amanda, Winty Septiani   +3 more
doaj   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Treatment of ischaemic stroke with prostacyclin.

, 1983
Ten patients with ischaemic stroke were treated with prostacyclin (2.5-5.0 ng/kg/min i.v. in 6 h courses 4-10 times during 1-2.5 days). In all patients a dramatic regression of hemiplegia, or hemiparesis, or aphasia occurred in the first few hours of ...
J Kusmiderski, A Dembinska-Kiec, R J Gryglewski, E Kostka-Trabka, M Basista, S Nowak, K Bieron, B Blaszczyk   +7 more
core   +1 more source

Effects of a single bout of strenuous exercise on platelet activation in female ApoE/LDLR−/− mice

Platelets, 2017
Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators, including prostacyclin (PGI2) and nitric oxide (NO).
K. Przyborowski, H. Kassassir, M. Wojewoda, K. Kmiecik, B. Sitek, K. Siewiera, A. Zakrzewska, A. M. Rudolf, R. Kostogrys, C. Watala, J. A. Zoladz, S. Chlopicki   +11 more
doaj   +1 more source