Results 71 to 80 of about 36,320 (224)

Influence of menstrual cycle phase on inflammatory and vascular responses to acute passive heating in healthy young women

Experimental Physiology, EarlyView.
Abstract The aim of this study was to determine whether inflammatory and vascular responses to passive heating differ between the early follicular phase (EFP) and the mid‐luteal phase (MLP) of the menstrual cycle. Ten healthy, naturally menstruating females (26 ± 3 years of age; body mass index 21.4 ± 1.9 kg/m2) were assessed during EFP and MLP ...
Yunuo Su, Emma O'Donnell, Stephen J. Bailey, Christof A. Leicht   +3 more
wiley   +1 more source

PTGIS (prostaglandin I2 (prostacyclin) synthase) [PDF]

, 2010
Review on PTGIS (prostaglandin I2 (prostacyclin) synthase), with data on DNA, on the protein encoded, and where the gene is ...
I Cebola, MA Peinado, Cebola, I, Peinado, MA   +3 more
core   +1 more source

The acute and chronic effects of local aerobic exercise on cardiovascular physiology

Experimental Physiology, EarlyView.
Abstract Exercise training has beneficial effects for primary and secondary prevention of cardiovascular disease (CVD). Effects of exercise training have typically been studied in the form of whole‐body exercise training, partly driven by the assumption that larger effects of exercise training can be achieved by involving more and larger muscle groups.
Myrthe P. F. van de Ven, Janneke Vloet, Daphne Merkus, Dick H. J. Thijssen   +3 more
wiley   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Prostacyclin mediates endothelial COX-2-dependent neuroprotective effects during excitotoxic brain injury

, 2014
Ying An,1,2 Natalya Belevych,1,2 Yufen Wang,1,2 Hao Zhang,1 Jason S Nasse,3 Harvey Herschman,4 Qun Chen,1,2 Andrew Tarr,1,2 Xiaoyu Liu,1,2 Ning Quan1,21Institute for Behavior Medicine Research, 2Department of Oral Biology, College of Dentistry ...
Liu X, Chen Q, Belevych N, Herschman H, Zhang H, Quan N, An Y, Wang Y, Tarr A, Nasse JS   +9 more
core  

Ischemic Preconditioning Improves Microvascular Endothelial Function in Remote Vasculature by Enhanced Prostacyclin Production

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
BACKGROUND The mechanisms underlying the effect of preconditioning on remote microvasculature remains undisclosed. The primary objective was to document the remote effect of ischemic preconditioning on microvascular function in humans.
Nicolai Rytter, Howard Carter, Peter Piil, Henrik Sørensen, Thomas Ehlers, Frederik Holmegaard, Christoffer Tuxen, Helen Jones, Dick Thijssen, Lasse Gliemann, Ylva Hellsten   +10 more
doaj   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Congruency between clinician‐assessed risk and calculated risk of 1‐year mortality in patients with pulmonary arterial hypertension: A retrospective chart review

Pulmonary Circulation
The objective of this analysis was to compare clinician‐based and formally calculated risk assessments by REVEAL Lite 2 and COMPERA 2.0 and to characterize parenteral prostacyclin utilization within 90 days of baseline in high‐risk patients. A multisite,
Amresh Raina, Margaret R. Sketch, Benjamin Wu, Meredith Broderick, Oksana A. Shlobin   +4 more
doaj   +1 more source

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3611-3621, October 2026.
Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH ...
Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya Uchida   +13 more
wiley   +1 more source

Cigarette smoke impairs endothelial cell prostacyclin production.

, 1986
Production of prostacyclin by endothelial cells is considered to be important in rendering the vessel wall nonthrombogenic. Cigarette smoking is an important risk factor in the pathogenesis of atherosclerosis. Here we show that the incubation of cultured
H J Brinkman, J A van Mourik, P G de Groot, J H Reinders   +3 more
core   +1 more source