Results 81 to 90 of about 36,320 (224)

Beyond the Heart‐Lung Axis: A Review of the Crosstalk Between the Hemodynamic, Neurohormonal, and Immune Systems in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Pulmonary hypertension is driven by dynamic crosstalk beyond the physical connection between the heart and lung, involving neurohormonal systems, immune pathways, and peripheral organs. This review highlights how multisystem signaling contributes to disease progression and may reveal new diagnostic and therapeutic targets.
Alejandro A. Vega, Juliet M. Alfaro, David S. Pinto, Maryam Emamimeybodi, Soban Umar   +4 more
wiley   +1 more source

PROSTACYCLIN SYNTHESIS IN HUMAN LYMPHATICS

, 2017
The ability of human lymphatics to generate prostacyclinin important amounts (4.5 ± 2.1 pg/mg/min)is described. The prostacyclin produced, exhib its thesame properties as reported for arterial and venoustissue. No age and sex difference could be observed.
Sinzinger, H, Oppolzer, R, Silberbauer, K, Mannheimer, E   +3 more
core  

Nitrates do not affect prostacyclin formation by rat arteries: this is unrelated to increased vascular prostacyclin formation with age

, 1987
The question of whether vasodilator nitrates act by releasing prostacyclin is controversial. Since the ability of blood vessels to form prostacyclin changes with age, we have investigated whether this may explain the discrepancies in the literature.
I F Stamford, P B Melhuish, A Bennett
core   +1 more source

Major urinary metabolites of 6-keto-prostaglandin F2α in mice[S]

Journal of Lipid Research, 2013
Western diets are enriched in omega-6 vs. omega-3 fatty acids, and a shift in this balance toward omega-3 fatty acids may have health benefits. There is limited information about the catabolism of 3-series prostaglandins (PG) formed from eicosapentaenoic
Dmitry V. Kuklev, Joseph A. Hankin, Charis L. Uhlson, Yu H. Hong, Robert C. Murphy, William L. Smith   +5 more
doaj   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

Pulmonary Arterial Hypertension Associated With Chronic Mephedrone Use: A Case Report

Pulmonary Circulation, Volume 16, Issue 4, October 2026.
ABSTRACT Mephedrone is a synthetic cathinone with sympathomimetic effects, but has not previously been linked to pulmonary arterial hypertension (PAH). We report a 42‐year‐old woman with no prior cardiopulmonary disease who presented with severe pre‐capillary PAH after a decade of near‐daily mephedrone use.
Masoud Kashoub, Michael Plunkett, Heba Nashat, Konstantinos Dimopoulos, Colm McCabe, Carl Harries, S. John Wort, Paul I. Dargan, Laura C. Price   +8 more
wiley   +1 more source

A Review of Nonsteroidal Anti‐Inflammatory Drugs for Food‐Producing Animals With a Focus on Potential Applications for Farmed Finfish

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English, Christine Huynh, William Roy, James W. Wynne, Hamish Rodger   +4 more
wiley   +1 more source

Thromboxane and prostacyclin differentially regulate murine extracellular matrix gene expression [PDF]

, 1993
Thromboxane and prostacyclin differentially regulate murine extracellular matrix gene expression. Alterations in the arachidonic acid metabolites thromboxane and prostacyclin are known to contribute to hemodynamic changes observed in certain models of ...
Horigan, Elizabeth A., Pellicoro, Jill A., Klotman, Paul E., Bruggeman, Leslie A.   +3 more
core   +1 more source

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Geisslinger, Gerd, Rolf M. Nusing, Gerd Geisslinger, Scholich, Klaus, Angioni, Carlo Federico, Klaus Scholich, Laura Popp, Brenneis, Christian, Ovidiu Coste, Becker, Wiebke, Popp, Laura, Nusing, Rolf M., Coste, Ovidiu, Carlo Angioni, Christian Brenneis, Ronald Schmidt, Wiebke Becker, Schmidt, Ronald   +17 more
core   +1 more source

Echocardiographic Effects of Prostacyclin? [PDF]

Circulation, 1998
To the Editor: I read with interest the manuscript by Hinderliter and other members of the Primary Pulmonary Hypertension Study Group entitled “Effects of Long-term Infusion of Prostacyclin (Epoprostenol) on Echocardiographic Measures of Right Ventricular Structure and Function in Primary Pulmonary Hypertension.”1 I was disappointed that the authors ...
openaire   +2 more sources