Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain [PDF]
Journal of Neuroinflammation, 2011 Background Although cyclooxygenases (COX) and prostaglandin E synthases (PGES) have been implicated in ischemic stroke injury, little is known about their role in intracerebral hemorrhage (ICH)-induced brain damage. This study examines the expression and
Wu He, Wu Tao, Wang Jessica, Wang Jian
doaj +3 more sources
Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy [PDF]
Journal of Diabetes Research, 2016 Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2
Lei Pang +5 more
doaj +5 more sources
Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle. [PDF]
Reproduction, 2004 Cyclooxygenase (COX), a rate-limiting enzyme that produces prostaglandins (PGs) from arachidonic acid, exists in two isoforms, COX-1 and COX-2. PGE2 synthase (PGES) is a terminal prostanoid synthase and can enzymatically convert the cyclooxygenase ...
T. Sun +5 more
semanticscholar +2 more sources
Journal of Endocrinology, 2005 Most preterm deliveries are associated with infection and inflammation. Prostaglandin E2 (PGE2) is one of the most important mediators in the processes of inflammation, and is converted from PGH2 by various kinds of PGE synthases (PGESs).
K. Kubota +6 more
semanticscholar +2 more sources
Journal of Pharmacological Sciences, 2012 Prostaglandin E2 (PGE2) is a key molecule involved in the neuroinflammatory processes that characterize amyotrophic lateral sclerosis (ALS). Although PGE2 synthesis is regulated by PGE2 synthases (PGESs), the pathological role of PGESs in ALS still ...
Hiroko Miyagishi +3 more
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Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation. [PDF]
Am J Pathol, 2011 Båge T +12 more
europepmc +2 more sources
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis. [PDF]
Journal of biochemistry and molecular biology, 2005 Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases.
I. Kudo, M. Murakami
semanticscholar +2 more sources
Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model [PDF]
Journal of Immunology, 2003 D. Claveau +7 more
semanticscholar +2 more sources
Frontiers in Cellular Neuroscience, 2023 Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibiting ...
Ayaka Hirayama +12 more
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