Results 1 to 10 of about 71,664 (211)
Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain [PDF]
Journal of Neuroinflammation, 2011 Background Although cyclooxygenases (COX) and prostaglandin E synthases (PGES) have been implicated in ischemic stroke injury, little is known about their role in intracerebral hemorrhage (ICH)-induced brain damage. This study examines the expression and
Wu He, Wu Tao, Wang Jessica, Wang Jian
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Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation. [PDF]
Am J Pathol, 2011 The inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of chronic inflammatory diseases including periodontitis; it is synthesized by cyclooxygenases (COX) and the prostaglandin E synthases mPGES-1, mPGES-2, and cPGES.
Båge T +12 more
europepmc +6 more sources
Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis [PDF]
BMB Reports, 2005 Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases.
Ichiro Kudo, Makoto Murakami
semanticscholar +6 more sources
Prostaglandin E Synthases in Zebrafish [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 Objective— Prostaglandin E synthases (PGESs) are being explored as antiinflammtory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE2 formation, and deletion of microsomal (m)-PGES-1 ...
B. Pini +5 more
semanticscholar +3 more sources
Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
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Regulation of cytosolic prostaglandin E synthase by phosphorylation [PDF]
Biochemical Journal, 2004 cPGES [cytosolic PG (prostaglandin) E synthase] is constitutively expressed in various cells and can regulate COX (cyclo-oxygenase)-1-dependent immediate PGE2 generation. In the present study, we found that cPGES underwent serine phosphorylation, which was accelerated transiently after cell activation.
Tsuyoshi Kobayashi +7 more
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Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2. [PDF]
Arthritis research & therapy, 2005 Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Annaleise V. Sampey +2 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007 Prostaglandin E2 (PGE2) is a key mediator involved in several inflammatory conditions. In this study, we investigated the expression and regulation of the terminal PGE2 synthesizing enzyme prostaglandin E synthases (mPGES-1, mPGES-2 and cPGES) in gingival fibroblasts stimulated with pro-inflammatory cytokines.
Tove Båge +4 more
semanticscholar +4 more sources
Journal of Diabetes Research, 2016 Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2
Lei Pang +5 more
doaj +2 more sources
Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle [PDF]
Reproduction, 2004 Cyclooxygenase (COX), a rate-limiting enzyme that produces prostaglandins (PGs) from arachidonic acid, exists in two isoforms, COX-1 and COX-2. PGE2 synthase (PGES) is a terminal prostanoid synthase and can enzymatically convert the cyclooxygenase ...
Tong Sun +5 more
openalex +2 more sources