Results 1 to 10 of about 6,685 (245)
Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
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Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain [PDF]
Journal of Neuroinflammation, 2011 Background Although cyclooxygenases (COX) and prostaglandin E synthases (PGES) have been implicated in ischemic stroke injury, little is known about their role in intracerebral hemorrhage (ICH)-induced brain damage. This study examines the expression and
Wu He, Wu Tao, Wang Jessica, Wang Jian
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Regulation of cytosolic prostaglandin E synthase by phosphorylation [PDF]
Biochemical Journal, 2004 cPGES [cytosolic PG (prostaglandin) E synthase] is constitutively expressed in various cells and can regulate COX (cyclo-oxygenase)-1-dependent immediate PGE2 generation. In the present study, we found that cPGES underwent serine phosphorylation, which was accelerated transiently after cell activation.
Tsuyoshi Kobayashi +7 more
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Regulation of Cytosolic Prostaglandin E Synthase
Journal of Health Science, 2007 Biosynthesis of prostaglandin E2 (PGE2), the most common prostanoid with potent and various biological activities, is regulated by three sequential steps of cyclooxygenase (COX) pathway. We reported the molecular identification of cytosolic prostaglandin E synthase (cPGES), a terminal enzyme of the COX-mediated PGE2 biosynthetic pathway.
Yoshihito Nakatani
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Expression of prostaglandin E synthase in Barrett’s cancer [PDF]
Diseases of the Esophagus, 2007 Expression of prostaglandin E synthase (PGES) - an enzyme of the prostaglandin biosynthetic pathway with suspected impact on carcinogenesis--was studied in Barrett's cancer to determine its pathogenetic role and prognostic impact in this entity. Expression analysis of PGES was performed on mRNA level (quantitative reverse transcription polymerase chain
Burkhard H.A. von Rahden +6 more
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Microsomal Prostaglandin E Synthase Family [PDF]
, 2020 National Cancer Institute
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Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation. [PDF]
Am J Pathol, 2011 Båge T +12 more
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Marked expression of prostaglandin E synthases in endometriosis [PDF]
Fertility and Sterility, 2008 Cédric Carli +5 more
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Frontiers in Cellular Neuroscience, 2023 Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibiting ...
Ayaka Hirayama +12 more
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Prostaglandin E Synthases in Zebrafish [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Objective— Prostaglandin E synthases (PGESs) are being explored as antiinflammtory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE 2 formation, and deletion of microsomal (m)-PGES-1 abrogates inflammation ...
Pini, Barbara +5 more
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