Results 11 to 20 of about 6,685 (245)

Potent ovarian development as being stimulated by cocktail hormone in the female Scylla olivacea

Frontiers in Marine Science, 2023
The mud crab Scylla olivacea is widely cultured for its economic value, but reproduction issues limit its production. Vitellogenesis-inhibiting hormone (VIH), serotonin (5-HT), and gonadotropin-releasing hormone (GnRH) are important neurohormones that ...
Jirawat Saetan, Supawadee Duangprom, Sineenart Songkoomkrong, Prateep Amonruttanapun, Teva Phanaksri, Piyaporn Surinlert, Chompunut Samhuay, Montakan Tamtin, Saowaros Suwansa-Ard, Scott F. Cummins, Scott F. Cummins, Prasert Sobhon, Napamanee Kornthong   +12 more
doaj   +1 more source

An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis. [PDF]

PLoS Pathogens, 2008
Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain.
Nourtan F Abdeltawab, Ramy K Aziz, Rita Kansal, Sarah L Rowe, Yin Su, Lidia Gardner, Charity Brannen, Mohammed M Nooh, Ramy R Attia, Hossam A Abdelsamed, William L Taylor, Lu Lu, Robert W Williams, Malak Kotb   +13 more
doaj   +1 more source

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases [PDF]

Frontiers in Pharmacology, 2011
Microsomal prostaglandin E synthase-1 (mPGES-1) is a well-recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding ...
Marina eKorotkova, Marina eKorotkova, Per Johan Jakobsson   +2 more
openaire   +3 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. [PDF]

PLoS ONE, 2014
Varicose veins are elongated and dilated saphenous veins. Despite the high prevalence of this disease, its pathogenesis remains unclear.In this study, we investigated the control of matrix metalloproteinases (MMPs) expression by prostaglandin (PG)E₂ ...
Ingrid Gomez, Chabha Benyahia, Liliane Louedec, Guy Leséche, Marie-Paule Jacob, Dan Longrois, Xavier Norel   +6 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis. [PDF]

PLoS ONE, 2016
Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting inflammation and fibrosis, impaired adaptive thermogenesis and increased lipolysis.
Verónica García-Alonso, Esther Titos, Jose Alcaraz-Quiles, Bibiana Rius, Aritz Lopategi, Cristina López-Vicario, Per-Johan Jakobsson, Salvadora Delgado, Juanjo Lozano, Joan Clària   +9 more
doaj   +1 more source

Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1 [PDF]

Trends in Cardiovascular Medicine, 2010
Both traditional and purpose-designed nonsteroidal anti-inflammatory drugs, selective for inhibition of cyclooxygenase (COX)-2, alleviate pain and inflammation but confer a cardiovascular hazard attributable to inhibition of COX-2-derived prostacyclin (PGI(2)).
Miao, Wang, Garret A, FitzGerald
openaire   +2 more sources

Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors [PDF]

Basic & Clinical Pharmacology & Toxicology, 2013
AbstractMicrosomal prostaglandin E synthase‐1 (mPGES‐1) is an inducible terminal synthase in PGE2 biosynthesis by inflammatory and cancer cells. Clinical and experimental data emphasize that mPGES‐1 might be a valuable target, with improved selectivity and safety compared to traditional NSAIDs or selective COX‐2 inhibitors, in the treatment of ...
Marina, Korotkova, Per-Johan, Jakobsson
openaire   +2 more sources

Expression of Microsomal Prostaglandin E Synthase-1 in the Spinal Cord in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Journal of Pharmacological Sciences, 2012
Prostaglandin E2 (PGE2) is a key molecule involved in the neuroinflammatory processes that characterize amyotrophic lateral sclerosis (ALS). Although PGE2 synthesis is regulated by PGE2 synthases (PGESs), the pathological role of PGESs in ALS still ...
Hiroko Miyagishi, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito   +3 more
doaj   +1 more source