Results 11 to 20 of about 71,694 (241)
Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis [PDF]
Journal of Biological Chemistry, 2003 Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase (COX)-2 in the PGE2-biosynthetic pathway. Given the accumulating evidence that COX-2-derived PGE2 participates in the development of various tumors, including colorectal cancer, we herein examined the potential involvement of ...
Daisuke Kamei +5 more
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Role of microsomal prostaglandin E synthase 1 in the kidney. [PDF]
Journal of the American Society of Nephrology, 2007 Prostaglandin E(2) (PGE(2)) is one of the most ubiquitous prostanoids in the kidney, where it may influence a wide range of physiologic functions. PGE(2) is generated through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases ...
H. François +5 more
semanticscholar +3 more sources
Journal of Endocrinology, 2005 Most preterm deliveries are associated with infection and inflammation. Prostaglandin E2 (PGE2) is one of the most important mediators in the processes of inflammation, and is converted from PGH2 by various kinds of PGE synthases (PGESs).
Ken Kubota +6 more
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Journal of Pharmacological Sciences, 2012 Prostaglandin E2 (PGE2) is a key molecule involved in the neuroinflammatory processes that characterize amyotrophic lateral sclerosis (ALS). Although PGE2 synthesis is regulated by PGE2 synthases (PGESs), the pathological role of PGESs in ALS still ...
Hiroko Miyagishi +3 more
doaj +2 more sources
Microsomal prostaglandin E synthase-1 and blood pressure regulation [PDF]
Kidney International, 2007 Prostaglandin E (PGE)(2) is a major arachidonic acid metabolite in a wide variety of tissues and is implicated in the control of inflammatory as well as physiological responses. At least three major forms of PGE synthase (PGES) have recently been cloned and characterized: membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).
Tianxin Yang
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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model [PDF]
Journal of Immunology, 2003 To better define the role of the various prostanoid synthases in the adjuvant-induced arthritis (AIA) model, we have determined the temporal expression of the inducible PGE synthase (mPGES-1), mPGES-2, the cytosolic PGES (cPGES/p23), and prostacyclin ...
David Claveau +7 more
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Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function [PDF]
Journal of Clinical Investigation, 2006 We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2 (PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and stroke. These inhibitors are believed to exert both their beneficial and their adverse effects by suppression of PGHS-2-derived prostacyclin (PGI(2)) and PGE(2).
Yan Cheng
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Cell Selective Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1 [PDF]
Circulation, 2013 Background— Global deletion of microsomal prostaglandin E synthase 1 (mPGES-1) in mice attenuates the response to vascular injury without a predisposition to thrombogenesis or hypertension.
Lihong Chen +6 more
semanticscholar +4 more sources
Nuclear Factor-Kappa B Regulates Inducible Prostaglandin E Synthase Expression in Human Amnion Mesenchymal Cells1 [PDF]
Biology of Reproduction, 2007 The human amnion is a major intrauterine source of prostaglandin (PG) E2, a potent mediator of uterine contractions and cervical ripening. During parturition, inflammatory cytokines promote PGE2 production through increased prostaglandin-endoperoxide ...
William E. Ackerman +4 more
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Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. [PDF]
MHR: Basic science of reproductive medicine, 2007 Since the controversies regarding the use of non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase (COX)-2 antagonists for the treatment of preterm labour (PTL), more emphasis has been placed on investigating the terminal synthases
S. Astle +4 more
semanticscholar +4 more sources