Results 11 to 20 of about 78,509 (319)
Role of microsomal prostaglandin E synthase 1 in the kidney. [PDF]
Journal of the American Society of Nephrology, 2007 Prostaglandin E(2) (PGE(2)) is one of the most ubiquitous prostanoids in the kidney, where it may influence a wide range of physiologic functions. PGE(2) is generated through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases ...
H. François +5 more
semanticscholar +3 more sources
Regulation of cytosolic prostaglandin E synthase by phosphorylation [PDF]
Biochemical Journal, 2004 cPGES [cytosolic PG (prostaglandin) E synthase] is constitutively expressed in various cells and can regulate COX (cyclo-oxygenase)-1-dependent immediate PGE2 generation. In the present study, we found that cPGES underwent serine phosphorylation, which was accelerated transiently after cell activation.
Tsuyoshi Kobayashi +7 more
openalex +4 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007 Prostaglandin E2 (PGE2) is a key mediator involved in several inflammatory conditions. In this study, we investigated the expression and regulation of the terminal PGE2 synthesizing enzyme prostaglandin E synthases (mPGES-1, mPGES-2 and cPGES) in gingival fibroblasts stimulated with pro-inflammatory cytokines.
Tove Båge +4 more
semanticscholar +4 more sources
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2. [PDF]
Arthritis research & therapy, 2005 Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Annaleise V. Sampey +2 more
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Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis [PDF]
Journal of Biological Chemistry, 2003 Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase (COX)-2 in the PGE2-biosynthetic pathway. Given the accumulating evidence that COX-2-derived PGE2 participates in the development of various tumors, including colorectal cancer, we herein examined the potential involvement of ...
Daisuke Kamei +5 more
openalex +5 more sources
Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. [PDF]
MHR: Basic science of reproductive medicine, 2007 Since the controversies regarding the use of non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase (COX)-2 antagonists for the treatment of preterm labour (PTL), more emphasis has been placed on investigating the terminal synthases
S. Astle +4 more
semanticscholar +4 more sources
Nuclear Factor-Kappa B Regulates Inducible Prostaglandin E Synthase Expression in Human Amnion Mesenchymal Cells1 [PDF]
Biology of Reproduction, 2008 W. Ackerman +4 more
semanticscholar +2 more sources
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function [PDF]
Journal of Clinical Investigation, 2006 We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2 (PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and stroke. These inhibitors are believed to exert both their beneficial and their adverse effects by suppression of PGHS-2-derived prostacyclin (PGI(2)) and PGE(2).
Yan Cheng
openalex +3 more sources
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2011 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Nicolaou, A +3 more
core +7 more sources
Potent ovarian development as being stimulated by cocktail hormone in the female Scylla olivacea
Frontiers in Marine Science, 2023 The mud crab Scylla olivacea is widely cultured for its economic value, but reproduction issues limit its production. Vitellogenesis-inhibiting hormone (VIH), serotonin (5-HT), and gonadotropin-releasing hormone (GnRH) are important neurohormones that ...
Jirawat Saetan +12 more
doaj +1 more source