Results 21 to 30 of about 71,694 (241)

Cellular mechanisms of taste disturbance induced by the non-steroidal anti-inflammatory drug, diclofenac, in mice

Frontiers in Cellular Neuroscience, 2023
Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibiting ...
Ayaka Hirayama, Ayaka Hirayama, Shusuke Iwata, Asami Oike, Yuko Kawabata, Yuki Nagasato, Shingo Takai, Keisuke Sanematsu, Keisuke Sanematsu, Keisuke Sanematsu, Ichiro Takahashi, Noriatsu Shigemura, Noriatsu Shigemura   +12 more
doaj   +1 more source

ATP Synthase: A Moonlighting Enzyme with Unprecedented Functions [PDF]

Chem. Commun., 2022, 58, 2650-2653, 2021
ATP synthase's intrinsic molecular electrostatic potential (MESP) adds constructively to, and hence reinforces, the chemiosmotic voltage. This ATP synthase voltage represents a new free energy term that appears to have been overlooked. This term is at least roughly equal in order of magnitude and opposite in sign to the energy needed to be dissipated ...
arxiv   +1 more source

Potent ovarian development as being stimulated by cocktail hormone in the female Scylla olivacea

Frontiers in Marine Science, 2023
The mud crab Scylla olivacea is widely cultured for its economic value, but reproduction issues limit its production. Vitellogenesis-inhibiting hormone (VIH), serotonin (5-HT), and gonadotropin-releasing hormone (GnRH) are important neurohormones that ...
Jirawat Saetan, Supawadee Duangprom, Sineenart Songkoomkrong, Prateep Amonruttanapun, Teva Phanaksri, Piyaporn Surinlert, Chompunut Samhuay, Montakan Tamtin, Saowaros Suwansa-Ard, Scott F. Cummins, Scott F. Cummins, Prasert Sobhon, Napamanee Kornthong   +12 more
doaj   +1 more source

An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis. [PDF]

PLoS Pathogens, 2008
Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain.
Nourtan F Abdeltawab, Ramy K Aziz, Rita Kansal, Sarah L Rowe, Yin Su, Lidia Gardner, Charity Brannen, Mohammed M Nooh, Ramy R Attia, Hossam A Abdelsamed, William L Taylor, Lu Lu, Robert W Williams, Malak Kotb   +13 more
doaj   +1 more source

The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense

BioFactors, Volume 48, Issue 6, Page 1217-1225, November/December 2022., 2022
Abstract Platelet‐activating factor (PAF, 1‐alkyl‐2‐acetyl‐sn‐glycero‐3‐phosphorylcholine) was discovered when the mechanisms involved in the deposition of immune complex in tissues were being scrutinized in the experimental model of rabbit serum sickness.
Mariano Sánchez Crespo, Olimpio Montero, Nieves Fernandez   +2 more
wiley   +1 more source

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases [PDF]

Frontiers in Pharmacology, 2011
Microsomal prostaglandin E synthase-1 (mPGES-1) is a well-recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding ...
Marina eKorotkova, Marina eKorotkova, Per Johan Jakobsson   +2 more
openaire   +4 more sources

Exosomes and their roles in the chemoresistance of pancreatic cancer

Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022
Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan, Honglin Tang, Qijun Li, Guangpeng Chen, Da Li   +4 more
wiley   +1 more source

Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. [PDF]

PLoS ONE, 2014
Varicose veins are elongated and dilated saphenous veins. Despite the high prevalence of this disease, its pathogenesis remains unclear.In this study, we investigated the control of matrix metalloproteinases (MMPs) expression by prostaglandin (PG)E₂ ...
Ingrid Gomez, Chabha Benyahia, Liliane Louedec, Guy Leséche, Marie-Paule Jacob, Dan Longrois, Xavier Norel   +6 more
doaj   +1 more source

Roles of three putative salmon louse (Lepeophtheirus salmonis) prostaglandin E2 synthases in physiology and host–parasite interactions

Parasites & Vectors, 2021
Background The salmon louse ( Lepeophtheirus salmonis ) is a parasite of salmonid fish. Atlantic salmon ( Salmo salar ) exhibit only a limited and ineffective immune response when infested with this parasite.
S. Dalvin, C. Eichner, Michael Dondrup, Aina-Cathrine Øvergård   +3 more
semanticscholar   +1 more source

Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis. [PDF]

PLoS ONE, 2016
Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting inflammation and fibrosis, impaired adaptive thermogenesis and increased lipolysis.
Verónica García-Alonso, Esther Titos, Jose Alcaraz-Quiles, Bibiana Rius, Aritz Lopategi, Cristina López-Vicario, Per-Johan Jakobsson, Salvadora Delgado, Juanjo Lozano, Joan Clària   +9 more
doaj   +1 more source