An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis. [PDF]
PLoS Pathogens, 2008 Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain.
Nourtan F Abdeltawab +13 more
doaj +1 more source
Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases [PDF]
Frontiers in Pharmacology, 2011 Microsomal prostaglandin E synthase-1 (mPGES-1) is a well-recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding ...
Marina eKorotkova +2 more
openaire +4 more sources
Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. [PDF]
PLoS ONE, 2014 Varicose veins are elongated and dilated saphenous veins. Despite the high prevalence of this disease, its pathogenesis remains unclear.In this study, we investigated the control of matrix metalloproteinases (MMPs) expression by prostaglandin (PG)E₂ ...
Ingrid Gomez +6 more
doaj +1 more source
Parasites & Vectors, 2021 Background The salmon louse ( Lepeophtheirus salmonis ) is a parasite of salmonid fish. Atlantic salmon ( Salmo salar ) exhibit only a limited and ineffective immune response when infested with this parasite.
S. Dalvin +3 more
semanticscholar +1 more source
Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis. [PDF]
PLoS ONE, 2016 Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting inflammation and fibrosis, impaired adaptive thermogenesis and increased lipolysis.
Verónica García-Alonso +9 more
doaj +1 more source
Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1 [PDF]
Trends in Cardiovascular Medicine, 2010 Both traditional and purpose-designed nonsteroidal anti-inflammatory drugs, selective for inhibition of cyclooxygenase (COX)-2, alleviate pain and inflammation but confer a cardiovascular hazard attributable to inhibition of COX-2-derived prostacyclin (PGI(2)).
Garret A. FitzGerald, Miao Wang
openaire +3 more sources
Microsomal prostaglandin E synthase-1 and blood pressure regulation [PDF]
Kidney International, 2007 Prostaglandin E (PGE)(2) is a major arachidonic acid metabolite in a wide variety of tissues and is implicated in the control of inflammatory as well as physiological responses. At least three major forms of PGE synthase (PGES) have recently been cloned and characterized: membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).
Tianxin Yang
openalex +4 more sources
Maternal recognition of pregnancy in the horse : are MicroRNAs the secret messengers? [PDF]
, 2020 The signal for maternal recognition of pregnancy (MRP) has still not been identified in the horse. High-throughput molecular biology at the embryo-maternal interface has substantially contributed to the knowledge on pathways affected during MRP, but an ...
Deforce, Dieter +11 more
core +2 more sources
Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors [PDF]
Basic & Clinical Pharmacology & Toxicology, 2013 AbstractMicrosomal prostaglandin E synthase‐1 (mPGES‐1) is an inducible terminal synthase in PGE2 biosynthesis by inflammatory and cancer cells. Clinical and experimental data emphasize that mPGES‐1 might be a valuable target, with improved selectivity and safety compared to traditional NSAIDs or selective COX‐2 inhibitors, in the treatment of ...
Per-Johan Jakobsson, Marina Korotkova
openaire +3 more sources
Selective COX-2 inhibitors and risk of myocardial infarction [PDF]
, 2005 Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V. +3 more
core +1 more source