Results 21 to 30 of about 6,685 (245)

The involvement of miR-6615-5p/Smad7 axis and immune imbalance in ammonia-caused inflammatory injury via NF-κB pathway in broiler kidneys

Poultry Science, 2020
Ammonia (NH3), a toxic gas, has deleterious effects on chicken health in intensive poultry houses. MicroRNA can mediate inflammation. The complex molecular mechanisms underlying NH3 inhalation–caused inflammation in animal kidneys are still unknown.
Qi Han, Jianyu Tong, Qi Sun, Xiaojie Teng, Hongfu Zhang, Xiaohua Teng   +5 more
doaj   +1 more source

Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E² Biosynthesis [PDF]

BMB Reports, 2005
Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties ...
Ichiro, Kudo, Makoto, Murakami
openaire   +2 more sources

Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy

Journal of Diabetes Research, 2016
Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2
Lei Pang, Yin Cai, Eva Hoi Ching Tang, Michael G. Irwin, Haichun Ma, Zhengyuan Xia   +5 more
doaj   +1 more source

15-deoxy-Δ12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Journal of Lipid Research, 2006
Prostaglandin (PG) E2 (PGE2) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE2 is accomplished by conversion of the cyclooxygenase (COX) product PGH2 by several terminal prostaglandin E synthases (PGES).
Oliver Schroäder, Yulyana Yudina, Alan Sabirsh, Nadine Zahn, Jesper Z. Haeggstroäm, Juärgen Stein   +5 more
doaj   +1 more source

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

BMC Genomics, 2010
Background Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor α (TNFα)
Modéer Thomas, Lundeberg Joakim, Lindberg Johan, Båge Tove, Yucel-Lindberg Tülay   +4 more
doaj   +1 more source

Regulation of prostaglandin E synthases: Effects of siRNA-mediated inhibition of microsomal prostaglandin E synthase-1

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
Prostaglandin E2 (PGE2) is a key mediator involved in several inflammatory conditions. In this study, we investigated the expression and regulation of the terminal PGE2 synthesizing enzyme prostaglandin E synthases (mPGES-1, mPGES-2 and cPGES) in gingival fibroblasts stimulated with pro-inflammatory cytokines.
Båge, Tove, Modéer, Thomas, Kawakami, Tomomi, Quezada, Hernan Concha, Yucel-Lindberg, Tülay   +4 more
openaire   +2 more sources

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

Journal of Neuroinflammation, 2009
Resveratrol, a polyphenol present in grapes and red wine, has been studied due to its vast pharmacological activity. It has been demonstrated that resveratrol inhibits production of inflammatory mediators in different in vitro and in vivo models.
Candelario-Jalil Eduardo, Bhatia Harsharan S, de Oliveira Antonio, Wendeburg Lena, Fiebich Bernd L   +4 more
doaj   +1 more source

Keel Fracture Causes Stress and Inflammatory Responses and Inhibits the Expression of the Orexin System in Laying Hens

Animals, 2019
Keel fracture has negative effects on the health and welfare of laying hens. We investigated effects of keel fracture on stress, inflammation, and the orexin system in laying hens.
Haidong Wei, Chun Li, Hongwei Xin, Shuang Li, Yanju Bi, Xiang Li, Jianhong Li, Runxiang Zhang, Jun Bao   +8 more
doaj   +1 more source

Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease [PDF]

Alzheimer's & Dementia, 2007
BackgroundThe proinflammatory prostaglandin E2 (PGE2) fluctuates over time in the cerebrospinal fluid of patients with Alzheimer's disease (AD), but the cerebral distribution and expression patterns of microsomal prostaglandin‐E synthase (mPGES)–1 have not been compared with those of normal human brains.MethodsMiddle frontal gyrus tissue from AD and ...
Uzma A, Chaudhry, Hean, Zhuang, Barbara J, Crain, Sylvain, Doré   +3 more
openaire   +2 more sources

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.

Arthritis research & therapy, 2005
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J   +2 more
openaire   +2 more sources