Protease‐activated receptors: An illustrated review [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Proteases are important regulators of cell behavior, survival, and apoptosis. They communicate to cells directly through a special class of G‐protein–coupled receptors known as protease‐activated receptors (PARs). N‐terminal PAR proteolysis unmasks a neo‐
Xu Han +2 more
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Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch [PDF]
Pharmaceuticals, 2023 Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of itch is mediated through a subclass of primary afferent sensory neurons, termed pruriceptors, which express molecular receptors that are activated by itch ...
Merab G. Tsagareli +3 more
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Zebrafish sperm outsource activation to eggs' protease-activated receptors. [PDF]
PLoS BiologyThe calcium surge that starts embryogenesis varies across species and is elusive in many. A new study in PLOS Biology shows that zebrafish eggs self-activate, initiating a protease-activated receptor calcium wave and uncovering a novel pathway in egg ...
Rafael A Fissore +2 more
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Biased Signaling of Protease-activated Receptors [PDF]
Frontiers in Endocrinology, 2014 In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain and repair mechanisms.
Peishen eZhao +3 more
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Protease-Activated Receptors in the Intestine: Focus on Inflammation and Cancer [PDF]
Frontiers in Endocrinology, 2019 Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family. Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically soluble ligands able to induce their activation.
Morgane Sébert +4 more
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Increased expression of protease-activated receptors 2 indicates poor prognosis in HBV related hepatocellular carcinoma [PDF]
Infectious Agents and Cancer, 2019 Objective To investigate the potential role of protease-activated receptor 2 (PAR2) in the prognosis of hepatocellular carcinoma (HCC). Methods A total of 202 HCC patients who underwent liver resections were included.
Peng Chen +4 more
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Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases [PDF]
Thrombosis Journal, 2019 Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecular targets, protease-activated receptors (PARs)
Dorothea M. Heuberger +1 more
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The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells [PDF]
Frontiers in OncologyBackgroundGlioblastoma (GBM) remains the most aggressive and common malignant brain tumor in adults, often accompanied by venous thromboembolism due to hypercoagulability.
Sandra Bien-Möller +14 more
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Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling [PDF]
Cell Communication and SignalingCoagulation factors are responsible for blood clot formation yet have also non-canonical functions as signalling molecules. In this context, they can activate protease-activated receptors (PARs) ubiquitously expressed in the vasculature.
Anxhela Habibi +2 more
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Serine proteases and protease-activated receptors signaling in the kidney. [PDF]
Am J Physiol Cell PhysiolFedoriuk M +6 more
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