Results 11 to 20 of about 211,038 (237)

Corrigendum: Biased signaling of protease-activated receptors [PDF]

Frontiers in Endocrinology, 2015
Peishen eZhao, Matthew eMetcalf, Nigel W. Bunnett, Nigel W. Bunnett   +3 more
doaj   +2 more sources

Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902

Platelets, 2021
The thrombin receptor, protease-activated receptor 4 (PAR4), is important for platelet activation and is the target of emerging anti-thrombotic drugs. A frequently occurring single nucleotide polymorphism (SNP; rs773902) causes a function-altering PAR4 ...
Simeng Li, Volga Tarlac, Roberto B. I. Christanto, Shauna L. French, Justin R. Hamilton   +4 more
doaj   +1 more source

Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload

JACC: Basic to Translational Science, 2020
Summary: Activated factor X is a key component of the coagulation cascade, but whether it directly regulates pathological cardiac remodeling is unclear.
Xinji Guo, PhD, Mikhail A. Kolpakov, MD, PhD, Bahman Hooshdaran, PhD, William Schappell, BS, Tao Wang, MD, PhD, Satoru Eguchi, MD, PhD, Katherine J. Elliott, PhD, Douglas G. Tilley, PhD, A. Koneti Rao, MD, Patricia Andrade-Gordon, PhD, Matthew Bunce, PhD, Chintala Madhu, PhD, Steven R. Houser, PhD, Abdelkarim Sabri, PhD   +13 more
doaj   +1 more source

Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype. [PDF]

PLoS ONE, 2015
For both wound healing and the formation of a fibrotic lesion, circulating monocytes enter the tissue and differentiate into fibroblast-like cells called fibrocytes and pro-fibrotic M2a macrophages, which together with fibroblasts form scar tissue ...
Michael J V White, Richard H Gomer
doaj   +1 more source

Plasma heparin cofactor II activity is inversely associated with albuminuria and its annual deterioration in patients with diabetes

Journal of Diabetes Investigation, 2021
Aims/Introduction Thrombin exerts various pathophysiological functions by activating protease‐activated receptors (PARs). Recent data have shown that PARs influence the development of glomerular diseases including diabetic kidney disease (DKD) by ...
Tomoyo Hara, Ryoko Uemoto, Akiko Sekine, Yukari Mitsui, Shiho Masuda, Kiyoe Kurahashi, Sumiko Yoshida, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Yasumasa Ikeda, Itsuro Endo, Soichi Honda, Katsuhiko Yoshimoto, Akira Kondo, Toshiaki Tamaki, Toshio Matsumoto, Munehide Matsuhisa, Masahiro Abe, Ken‐ichi Aihara   +19 more
doaj   +1 more source

Protease-activated receptors and inflammatory hyperalgesia

Memorias do Instituto Oswaldo Cruz, 2005
Recent advances in basic science pointed to a role for proteinases, through the activation of proteinase-activated receptors (PARs) in nociceptive mechanisms.
Nathalie Vergnolle
doaj   +1 more source

Inhibition of Serine Proteases as a Novel Therapeutic Strategy for Abdominal Pain in IBS

Frontiers in Physiology, 2022
Serine proteases are heavily present in the gastrointestinal tract where they are essential in numerous physiological processes. An imbalance in the proteolytic activity is a central mechanism underlying abdominal pain in irritable bowel syndrome (IBS ...
Lisse Decraecker, Guy Boeckxstaens, Alexandre Denadai-Souza   +2 more
doaj   +1 more source

Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis

Pharmaceuticals, 2013
Platelets contribute fundamentally to ischemic heart disease, and antiplatelet therapy has been critical to reducing acute thrombotic complications of atherosclerotic disease.
Susan S. Smyth, Eric L. Wallace
doaj   +1 more source

Protease-Activated Receptors – Key Regulators of Inflammatory Bowel Diseases Progression

Journal of Inflammation Research, 2021
Damian Jacenik,1 Jakub Fichna,2 Ewa Małecka-Wojciesko,3 Anna Mokrowiecka3 1Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland; 2Department of Biochemistry, Faculty of Medicine, Medical
Jacenik D, Fichna J, Małecka-Wojciesko E, Mokrowiecka A   +3 more
doaj  

Dynamic allostery in thrombin—a review

Frontiers in Molecular Biosciences, 2023
Thrombin is a serine protease that catalyzes a large number of different reactions including proteolytic cleave of fibrinogen to make the fibrin clot (procoagulant activity), of the protease activated receptors (for cell signaling) and of protein C ...
Elizabeth A. Komives
doaj   +1 more source