Results 21 to 30 of about 211,038 (237)
Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors
Haematologica, 2019 As platelet activation is an irreversible and potentially harmful event, platelet stimulatory signaling must be tightly regulated to ensure the filtering-out of inconsequential fluctuations of agonist concentrations in the vascular milieu.
Ankit S. Macwan +6 more
doaj +1 more source
Assessment of neonatal, cord, and adult platelet granule trafficking and secretion
Platelets, 2020 Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis.
Anh T. P. Ngo +12 more
doaj +1 more source
Cells, 2021 Background: Protease-activated receptor 1 (PAR1) and toll-like receptors (TLRs) are inflammatory mediators contributing to atherogenesis and atherothrombosis.
Julian Friebel +18 more
doaj +1 more source
Diversification of PAR signaling through receptor crosstalk
Cellular & Molecular Biology Letters, 2022 Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these interactions are not limited to members of the same family, but involve receptors as diverse as receptor kinases, prostanoid ...
Irene Lee-Rivera +2 more
doaj +1 more source
Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization
International Journal of Cell Biology, 2017 The serine protease thrombin activates Protease-Activated Receptors (PARs), a family of G-protein-coupled receptors (GPCRs) activated by the proteolytic cleavage of their extracellular N-terminal domain.
Alejandro Alvarez-Arce +4 more
doaj +1 more source
Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones
Molecular Pain, 2010 Protease-activated receptors (PAR1-4) are activated by proteases released by cell damage or blood clotting, and are known to be involved in promoting pain and hyperalgesia.
Magherini Pier C +7 more
doaj +1 more source
Biomolecules, 2022 Plasminogen and its multiple receptors have been implicated in the responses of many different cell types. Among these receptors, histone 2B (H2B) has been shown to play a prominent role in macrophage responses.
Mitali Das +2 more
doaj +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Platelets, 2017 Thrombin is the most potent agonist of human platelets and its effects are primarily mediated through the protease-activated receptors (PARs)-1 and -4.
I. C. Moschonas +7 more
doaj +1 more source