Results 1 to 10 of about 3,645,726 (251)

A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor. [PDF]

PLoS ONE, 2013
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation.
Hu Wan, Kwang Sik Lee, Bo Yeon Kim, Feng Ming Zou, Hyung Joo Yoon, Yeon Ho Je, Jianhong Li, Byung Rae Jin   +7 more
doaj   +2 more sources

Production of Protease Inhibitor With Penicillium sp. — Optimization of the Medium for Growth in Pellet Form and Cytotoxicity Testing [PDF]

Engineering in Life Sciences
Penicillium sp. (IBWF 040‐09) produces a protease inhibitor that can potentially be used against the main protease of human African trypanosomiasis. Since the target substance is formed intracellularly (under nutrient limitation), the fungal pellet is ...
Winda Soerjawinata, Shila Prajapati, Isabelle Barth, Xiaohua Lu, Roland Ulber, Thomas Efferth, Percy Kampeis   +6 more
doaj   +2 more sources

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Cell, 2020
Markus Hoffmann, Nadine Krüger, Tobias S Schiergens   +2 more
exaly   +2 more sources

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Journal of Medicinal Chemistry, 2022
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety.
Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Y. Yamatsu, S. Yamamoto, Y. Maruyama, Y. Taoda, Koji Kasamatsu, Takahiro Suto, Kensuke Kouki, A. Nakahashi, Shohei Kawashima, T. Sanaki, Shinsuke Toba, K. Uemura, T. Mizutare, S. Ando, M. Sasaki, Y. Orba, H. Sawa, A. Sato, Takafumi Sato, Teruhisa Kato, Yuki Tachibana   +24 more
semanticscholar   +1 more source

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Nature Communications, 2021
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs.
B. Boras, Rhys M. Jones, B. Anson, D. Arenson, L. Aschenbrenner, M. Bakowski, N. Beutler, Joseph Binder, Emily Chen, H. Eng, Holly Hammond, J. Hammond, Robert E. Haupt, R. Hoffman, E. Kadar, R. Kania, Emi Kimoto, Melanie G. Kirkpatrick, L. Lanyon, E. Lendy, Jonathan R. Lillis, James Logue, S. Luthra, Chunlong Ma, S. Mason, M. McGrath, Stephen Noell, R. Obach, Matthew N. O’ Brien, Rebecca E O'connor, Kevin Ogilvie, D. Owen, Martin Pettersson, M. Reese, T. Rogers, R. Rosales, M. Rossulek, J. Sathish, N. Shirai, C. Steppan, M. Ticehurst, L. Updyke, S. Weston, Yuao Zhu, K. White, A. García-Sastre, Jun Wang, A. Chatterjee, A. Mesecar, M. Frieman, A. Anderson, C. Allerton   +51 more
semanticscholar   +1 more source

ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

Science Advances, 2021
ITIH4 forms complexes with proteases upon cleavage that inhibit proteolysis by a novel inhibitory mechanism. Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is proteolytically processed in multiple pathological ...
Rasmus Pihl, R. K. Jensen, E. Poulsen, L. Jensen, A. Hansen, I. Thøgersen, J. Dobó, P. Gál, G. Andersen, J. Enghild, S. Thiel   +10 more
semanticscholar   +1 more source

A TIL-Type Serine Protease Inhibitor Involved in Humoral Immune Response of Asian Corn Borer Ostrinia furnaculis

Frontiers in Immunology, 2022
To elucidate the application value of insect endogenous protease and its inhibitor genes in pest control, we analyzed in detail the transcriptome sequence of the Asian corn borer, Ostrinia furnacalis.
Ruobing Guan, Ruobing Guan, Shaoru Hu, Xiang Li, Shiheng An, Xuexia Miao, Haichao Li, Haichao Li   +7 more
doaj   +1 more source

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

Science, 2021
Description Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrough infections occur, and emerging variants present increased risk.
D. Owen, C. Allerton, A. Anderson, L. Aschenbrenner, M. Avery, S. Berritt, B. Boras, R. Cardin, A. Carlo, K. Coffman, A. Dantonio, L. Di, H. Eng, R. Ferre, K. Gajiwala, S. Gibson, S. Greasley, B. Hurst, E. Kadar, A. Kalgutkar, J. C. Lee, J. Lee, W. Liu, S. Mason, S. Noell, J. Novak, R. Obach, K. Ogilvie, N. Patel, M. Pettersson, D. Rai, M. Reese, M. Sammons, J. Sathish, R. Singh, C. Steppan, A. Stewart, J. Tuttle, L. Updyke, P. Verhoest, L. Wei, Q. Yang, Y. Zhu   +42 more
semanticscholar   +1 more source

Oxidative profile and protease regulator potential to predict sperm functionality in donkey (Equus asinus)

Scientific Reports, 2021
Seminal plasma (SP) of donkey stallions was evaluated using various oxidative stress parameters as well as protease and protease inhibitor activities. SP was obtained by nine donkey stallions.
Stefano Cecchini Gualandi, Brunella Giangaspero, Tommaso Di Palma, Giuseppe Macchia, Augusto Carluccio, Raffaele Boni   +5 more
doaj   +1 more source

HIV-1 Gag Non-Cleavage Site PI Resistance Mutations Stabilize Protease/Gag Substrate Complexes In Silico via a Substrate-Clamp

BioChem, 2021
HIV-1 protease active site inhibitors are a key part of antiretroviral therapy, though resistance can evolve rendering therapy ineffective. Protease inhibitor resistance typically starts with primary mutations around the active site, which reduces ...
Gary S. Laco
doaj   +1 more source